Ethylglykolimidathydrochlorid | 2955-92-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 甲亚胺酸及其衍生物
• 英文名称: Ethylglykolimidathydrochlorid
• 英文别名: 2-hydroxyacetimidic acid ethyl ester hydrochloride；Glykolimidsaeure-ethylester-hydrochlorid；glycolimidic acid ethyl ester; hydrochloride；Glykolimidsaeure-aethylester; Hydrochlorid；2-hydroxyethanimidic acid ethyl ester hydrochloride；ethyl 2-hydroxyacetimidate hydrochloride；ethyl hydroxyacetimidate chlorohydrate；1-Ethoxy-2-hydroxyethaniminium chloride；(1-ethoxy-2-hydroxyethylidene)azanium;chloride
• CAS: 2955-92-2
• 化学式: C₄H₉NO₂*ClH
• 分子量: 139.582
• InChiKey: WYRRCHSAVYXEJB-UHFFFAOYSA-N

物化性质

• 熔点：
  103 °C

计算性质

• 辛醇/水分配系数(LogP)：
  0.41
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  53.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Ethylglykolimidathydrochlorid 在 氨 作用下， 以 乙醇 为溶剂， 生成 2-羟基乙脒盐酸盐
  参考文献：
  名称：

  NITROGENATED FUSED RING DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE OF THE SAME FOR MEDICAL PURPOSES

  摘要：

  公开号：

  EP2143724B1
• 作为产物：
  描述：

  氰基甲醇 甲醛氰醇 在 盐酸 、 乙醚 、 乙醇 作用下， 生成 Ethylglykolimidathydrochlorid
  参考文献：
  名称：

  Houben; Pfankuch, Chemische Berichte, 1926, vol. 59, p. 2394

  摘要：

  DOI：

文献信息

• Compounds with antiparasitic activity and medicines containing same
  申请人：Vial Henri

  公开号：US20050176819A1

  公开（公告）日：2005-08-11

  The invention relates to compounds having an anti-parasitic, in particular antimalarial activity, characterized in that they correspond to general formula (I) Applications in particular as compounds with anti-parasitic activity.

  这项发明涉及具有抗寄生虫特别是抗疟活性的化合物，其特征在于它们符合一般式(I)。特别适用于具有抗寄生虫活性的化合物。
• 2-Mercaptoacetamidines as gastric antisecretory agents
  作者：William A. Bolhofer、Charles N. Habecker、Adolph M. Pietruszkiewicz、Mary Lou Torchiana、Henry I. Jacoby、Clement A. Stone

  DOI：10.1021/jm00189a015

  日期：1979.3

  A series of N-substituted 2-mercaptoacetamidines was synthesized and evaluated for gastric antisecretory activity in dogs stimulated with gastrin tetrapeptide. The most potent analogues showed 80--95% inhibition of acid secretion after an oral dose of 8 mg/kg. Thus, these compounds represent a new structural type having significant antisecretory activity. Disulfides had essentially the same antisecretory

  合成了一系列的N-取代的2-巯基乙am，并评价了用胃泌素四肽刺激的狗的胃抗分泌活性。口服剂量为8 mg / kg后，最有效的类似物显示出80--95％的酸分泌抑制作用。因此，这些化合物代表具有显着抗分泌活性的新结构类型。二硫化物与相应的巯基乙acet具有基本相同的抗分泌能力，表明代谢相互转化。巯基的烷基化降低了效力。较高的羧am同系物，例如2-和3-巯基丙ion，具有非常低的活性。羟乙am和巯基乙酰胺的药效也很低。用这一系列化合物观察到的副作用包括呕吐，心动过速和胃出血。
• Synthesis and antibacterial evaluation of novel 2-[N-Imidoylpyrrolidinyl] carbapenems
  作者：Kouji Hattori、Akira Yamada、Satoru Kuroda、Toshiyuki Chiba、Masayoshi Murata、Kazuo Sakane

  DOI：10.1016/s0960-894x(01)00753-3

  日期：2002.2

  The synthesis, antibacterial activity and DHP-susceptibility of a series of novel carbapenems, directly linked with heterocyclic moiety are described. Especially, the compounds linked pyrrolidine-carbapenem exhibited to have a good antibacterial activity against Staphylococcus aureus (MRSA) as well as Pseudomonas aeruginosa to maintain a good stability towards DHP-I.

  描述了直接与杂环部分连接的一系列新型碳青霉烯的合成，抗菌活性和DHP敏感性。尤其是，连接有吡咯烷-卡巴培南的化合物显示出对金黄色葡萄球菌（MRSA）以及铜绿假单胞菌具有良好的抗菌活性，以保持对DHP-1的良好稳定性。
• Arylheteroalkylamine derivatives and their use as inhibitors of nitric oxide synthase
  申请人：Cheshire David

  公开号：US20050143379A1

  公开（公告）日：2005-06-30

  There are provided novel compounds of formula (I), wherein R 1 , R 2 , R 3 , T, U, X, Y, V and W are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.

  提供了一种新化合物的公式(I)，其中R1、R2、R3、T、U、X、Y、V和W如规范所定义，并且其药学上可接受的盐、对映体和外消旋体；以及它们的制备方法、含有它们的组合物和它们在治疗中的用途。这些化合物是一氧化氮合酶抑制剂，因此在治疗或预防炎症性疾病和疼痛方面特别有用。
• Reverse-benzamidine antimalarial agents: Design, synthesis, and biological evaluation
  作者：Olivier Berger、Sharon Wein、Jean-Frederic Duckert、Marjorie Maynadier、Siham El Fangour、Roger Escale、Thierry Durand、Henri Vial、Yen Vo-Hoang

  DOI：10.1016/j.bmcl.2010.07.124

  日期：2010.10

  In the frame of the development of bis-cationic choline analogs, the RSA of bis-N-alkylamidines were studied and a new series of reverse-benzamidine derivatives was designed. Contrary to the lipophilicity, the basicity of alkylamidine compounds directly influences their antimalarial potencies. (C) 2010 Elsevier Ltd. All rights reserved.