(4E)-2-cyclohexyl-3-cyclohexylimino-4-trimethylsilanylmethylene-3,4-dihydro-2H-isoquinolin-1-one | 1196480-65-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: (4E)-2-cyclohexyl-3-cyclohexylimino-4-trimethylsilanylmethylene-3,4-dihydro-2H-isoquinolin-1-one
• 英文别名: (4E)-2-cyclohexyl-3-cyclohexylimino-4-(trimethylsilylmethylidene)isoquinolin-1-one
• CAS: 1196480-65-5
• 化学式: C₂₅H₃₆N₂OSi
• 分子量: 408.659
• InChiKey: MJHJVWLPXIVVBS-AJBJLGRJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.47
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-[(三甲基硅基)乙炔基]苯甲醛 、 N,N'-二环己基碳二亚胺 在 1,3-双(二苯基膦)丙烷 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以34%的产率得到(4E)-2-cyclohexyl-3-cyclohexylimino-4-trimethylsilanylmethylene-3,4-dihydro-2H-isoquinolin-1-one
  参考文献：
  名称：

  Synthesis of substituted 6-imino-2-piperidinones by Rh-catalyzed [4+2] annulation of 4-alkynals with carbodiimides

  摘要：

  Synthesis of substituted 6-imino-2-piperidinones has been achieved by cationic rhodium(1)/dppp complex-catalyzed [4+2] annulations of various 4-alkynals with carbodiimides at room temperature. The reactions of benzene-linked 4-alkynals (2-alkynylbenzaldehydes) and carbodiimides also proceeded at room temperature, affording the corresponding 6-imino-2-piperidinones. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.06.115

文献信息

• Synthesis of substituted 6-imino-2-piperidinones by Rh-catalyzed [4+2] annulation of 4-alkynals with carbodiimides
  作者：Ken Tanaka、Marina Mimura、Daiki Hojo

  DOI：10.1016/j.tet.2009.06.115

  日期：2009.10

  Synthesis of substituted 6-imino-2-piperidinones has been achieved by cationic rhodium(1)/dppp complex-catalyzed [4+2] annulations of various 4-alkynals with carbodiimides at room temperature. The reactions of benzene-linked 4-alkynals (2-alkynylbenzaldehydes) and carbodiimides also proceeded at room temperature, affording the corresponding 6-imino-2-piperidinones. (C) 2009 Elsevier Ltd. All rights reserved.