(1E,4E)-1,5-bis(4-(4-methylpiperazin-1-yl)phenyl)penta-1,4-dien-3-one | 1338000-39-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (1E,4E)-1,5-bis(4-(4-methylpiperazin-1-yl)phenyl)penta-1,4-dien-3-one
• 英文别名: (1E,4E)-1,5-bis[4-(4-methylpiperazin-1-yl)phenyl]penta-1,4-dien-3-one
• CAS: 1338000-39-7
• 化学式: C₂₇H₃₄N₄O
• 分子量: 430.593
• InChiKey: LMZCIBHNLBICHL-FNCQTZNRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(4-甲基哌嗪)苯甲醛 、 丙酮 在 水 、 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 0.5h， 以85%的产率得到(1E,4E)-1,5-bis(4-(4-methylpiperazin-1-yl)phenyl)penta-1,4-dien-3-one
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimer’s disease

  摘要：

  A series of novel curcumin analogues were designed, synthesized, and evaluated as potential multifunctional agents for the treatment of AD. The in vitro studies showed that these compounds had better inhibitory properties against A beta aggregation than curcumin. Superior anti-oxidant properties (better than the reference compound Trolox) of these compounds were observed by the oxygen radical absorbance capacity (ORAC) method and a cell-based assay using DCFH-DA as a probe. In addition they were able to chelate metals such as iron and copper and decrease metal-induced A beta aggregation. The structure-activity relationships were discussed. The results suggested that our curcumin analogues could be selected as multifunctional agents for further investigation of AD treatment. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.07.033

文献信息

• Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimer’s disease
  作者：Shang-Ying Chen、Yuan Chen、Yan-Ping Li、Shu-Han Chen、Jia-Heng Tan、Tian-Miao Ou、Lian-Quan Gu、Zhi-Shu Huang

  DOI：10.1016/j.bmc.2011.07.033

  日期：2011.9

  A series of novel curcumin analogues were designed, synthesized, and evaluated as potential multifunctional agents for the treatment of AD. The in vitro studies showed that these compounds had better inhibitory properties against A beta aggregation than curcumin. Superior anti-oxidant properties (better than the reference compound Trolox) of these compounds were observed by the oxygen radical absorbance capacity (ORAC) method and a cell-based assay using DCFH-DA as a probe. In addition they were able to chelate metals such as iron and copper and decrease metal-induced A beta aggregation. The structure-activity relationships were discussed. The results suggested that our curcumin analogues could be selected as multifunctional agents for further investigation of AD treatment. (C) 2011 Elsevier Ltd. All rights reserved.