Ethyl 6-nitro-3-(trifluoromethyl)quinoxaline-2-carboxylate | 1243580-64-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: Ethyl 6-nitro-3-(trifluoromethyl)quinoxaline-2-carboxylate
• CAS: 1243580-64-4
• 化学式: C₁₂H₈F₃N₃O₄
• 分子量: 315.208
• InChiKey: TWFLXUGXRZJZLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  97.9
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  2-溴-3-氧代-4,4,4-三氟丁酸乙酯 、 4-硝基邻苯二胺 在 1-butyl-3-methylimidazolium Tetrafluoroborate 作用下， 反应 1.17h， 以86%的产率得到Ethyl 6-nitro-3-(trifluoromethyl)quinoxaline-2-carboxylate
  参考文献：
  名称：

  One-pot synthesis of quinoxaline-2-carboxylate derivatives using ionic liquid as reusable reaction media

  摘要：

  The catalyst-free one-pot synthesis of quinoxaline-2-carboxylate is reported by the reaction of alpha-halo-beta-ketoesters with 1,2-diamines using an ionic liquid as an environmentally benign solvent The recovered ionic liquid was reused for four to five cycles Moreover, the method is applicable for a variety of 1,2-diamines and alpha-halo-beta-ketoesters (c) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tetlet.2010.05.099

文献信息

• One-pot synthesis of quinoxaline-2-carboxylate derivatives using ionic liquid as reusable reaction media
  作者：H.M. Meshram、P. Ramesh、G. Santosh Kumar、B. Chennakesava Reddy

  DOI：10.1016/j.tetlet.2010.05.099

  日期：2010.8

  The catalyst-free one-pot synthesis of quinoxaline-2-carboxylate is reported by the reaction of alpha-halo-beta-ketoesters with 1,2-diamines using an ionic liquid as an environmentally benign solvent The recovered ionic liquid was reused for four to five cycles Moreover, the method is applicable for a variety of 1,2-diamines and alpha-halo-beta-ketoesters (c) 2010 Elsevier Ltd All rights reserved