Sulfidefluor-2 | 1311393-87-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: Sulfidefluor-2
• 英文别名: N-(6'-azido-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl)morpholine-4-carboxamide
• CAS: 1311393-87-9
• 化学式: C₂₅H₁₉N₅O₅
• 分子量: 469.456
• InChiKey: UYODVBRIJOULDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  35
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  91.5
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Sulfidefluor-2 在 sodium hydrogen sulfide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  FLUORESCENT PROBES FOR REACTIVE SULFUR SPECIES

  摘要：

  本发明提供了一种基于反应的荧光探针，用于活细胞中硫化氢的选择性成像。

  公开号：

  US20120329085A1
• 作为产物：
  描述：

  4-吗啉碳酰氯 在 sodium hydride 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 3.0h， 生成 Sulfidefluor-2
  参考文献：
  名称：

  Reaction-Based Fluorescent Probes for Selective Imaging of Hydrogen Sulfide in Living Cells

  摘要：

  Hydrogen sulfide (H2S) is emerging as an important mediator of human physiology and pathology but remains difficult to study, in large part because of the lack of methods for selective monitoring of this small signaling molecule in live biological specimens. We now report a pair of new reaction-based fluorescent probes for selective imaging of H2S in living cells that exploit the H2S-mediated reduction of azides to fluorescent amines. Sulfidefluor-1 (SF1) and Sulfidefluor-2 (SF2) respond to H2S by a turn-on fluorescence signal enhancement and display high selectivity for H2S over other biologically relevant reactive sulfur, oxygen, and nitrogen species. In addition, SF1 and SF2 can be used to detect H2S in both water and live cells, providing a potentially powerful approach for probing H2S chemistry in biological systems.

  DOI：

  10.1021/ja203661j

文献信息

• Fluorescent probes for reactive sulfur species
  申请人：Chang Christopher J.

  公开号：US09212189B2

  公开（公告）日：2015-12-15

  The invention provides reaction-based fluorescent probes for selective imaging of hydrogen sulfide in living cells.

  本发明提供了一种基于反应的荧光探针，可选择性地成像活细胞中的硫化氢。
• US9212189B2
  申请人：——

  公开号：US9212189B2

  公开（公告）日：2015-12-15
• FLUORESCENT PROBES FOR REACTIVE SULFUR SPECIES
  申请人：CHANG Christopher J.

  公开号：US20120329085A1

  公开（公告）日：2012-12-27

  The invention provides reaction-based fluorescent probes for selective imaging of hydrogen sulfide in living cells.

  本发明提供了一种基于反应的荧光探针，用于活细胞中硫化氢的选择性成像。
• Reaction-Based Fluorescent Probes for Selective Imaging of Hydrogen Sulfide in Living Cells
  作者：Alexander R. Lippert、Elizabeth J. New、Christopher J. Chang

  DOI：10.1021/ja203661j

  日期：2011.7.6

  Hydrogen sulfide (H2S) is emerging as an important mediator of human physiology and pathology but remains difficult to study, in large part because of the lack of methods for selective monitoring of this small signaling molecule in live biological specimens. We now report a pair of new reaction-based fluorescent probes for selective imaging of H2S in living cells that exploit the H2S-mediated reduction of azides to fluorescent amines. Sulfidefluor-1 (SF1) and Sulfidefluor-2 (SF2) respond to H2S by a turn-on fluorescence signal enhancement and display high selectivity for H2S over other biologically relevant reactive sulfur, oxygen, and nitrogen species. In addition, SF1 and SF2 can be used to detect H2S in both water and live cells, providing a potentially powerful approach for probing H2S chemistry in biological systems.