2-(diphenylmethyl)phenol | 4970-23-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 2-(diphenylmethyl)phenol
• 英文别名: 2-Hydroxy-triphenylmethan；alpha-Hydroxytriphenylmethan；2-benzhydrylphenol
• CAS: 4970-23-4
• 化学式: C₁₉H₁₆O
• 分子量: 260.335
• InChiKey: GTLQLIZHQIYYJY-UHFFFAOYSA-N

物化性质

• 熔点：
  124 °C
• 沸点：
  396.8±11.0 °C(Predicted)
• 密度：
  1.126±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(diphenylmethyl)phenol 、 碘甲烷 在 sodium methylate 作用下， 生成 ((2-甲氧基苯基)亚甲基)二苯
  参考文献：
  名称：

  Schmidt,O., Diss. Heidelberg <1898>, S. 28

  摘要：

  DOI：
• 作为产物：
  描述：

  ((2-甲氧基苯基)亚甲基)二苯 在 氢碘酸 、 溶剂黄146 作用下， 生成 2-(diphenylmethyl)phenol
  参考文献：
  名称：

  v. Liebig; Keim, Journal fur praktische Chemie (Leipzig 1954), 1907, vol. <2> 76, p. 275,368

  摘要：

  DOI：

文献信息

• The directed ortho-lithiation of aryl tetramethylphosphorodiamidates.
  作者：Mitsuaki WATANABE、Mutsuhiro DATE、Kenji KAWANISHI、Takako HORI、Sunao FURUKAWA

  DOI：10.1248/cpb.38.2637

  日期：——

  Aryl tetramethylphosphorodiamidates were effectively ortho-lithiated with sec-BuLi in tetrahydrofuran at -105°C.The resulting lithiated species were trapped with a variety of electrophiles at -105°C to provide ortho-substituted phosphorodiamidates. When the lithiation was carried out at -78°C, O→C migration of the bis(dimethylamino)phosphoryl group took place rapidly and 2-hydroxyarylphosphonic tetramethyldiamides were produced regioselectively. The ortho-directing ability of the phosphorodiamidates was investigated by intermolecular competition experiments with other directed metalation groups.

  芳基四甲基膦双胺盐在四氢呋喃中，以-105°C温度下通过第二丁基锂有效实现邻位锂化。所得锂化物种与各种亲电试剂在-105°C温度下反应，生成邻位取代的膦双胺盐。当锂化反应在-78°C进行时，双（二甲基氨基）膦基团迅速发生O→C迁移，选择性地生成2-羟基芳基膦酸四甲基双胺盐。通过与其他导向金属化基团的分子间竞争实验研究了膦双胺盐的邻位导向能力。
• ISOCYANATE PRODUCTION PROCESS
  申请人：Shinohata Masaaki

  公开号：US20110092731A1

  公开（公告）日：2011-04-21

  An object of the present invention is to provide a process that enables isocyanate to be produced stably over a long period of time and at high yield without encountering problems of the prior art during production of isocyanate without using phosgene. The present invention discloses a process for producing an isocyanate by subjecting a carbamic acid ester to a thermal decomposition reaction, including the steps of: recovering a low boiling point component in a form of a gaseous phase component from a thermal decomposition reaction vessel in which the thermal decomposition reaction is carried out; recovering a liquid phase component containing a carbamic acid ester from a bottom of the thermal decomposition reaction vessel; and supplying all or a portion of the liquid phase component to an upper portion of the thermal decomposition reaction vessel.

  本发明的一个目的是提供一种能够在长时间内稳定地高产且不使用光气的情况下生产异氰酸酯的方法，而不会遇到先前生产异氰酸酯时的问题。本发明公开了一种通过将氨基甲酸酯经受热分解反应来生产异氰酸酯的方法，包括以下步骤：从进行热分解反应的反应釜中回收形成气相组分的低沸点组分；从热分解反应釜底部回收含有氨基甲酸酯的液相组分；并将全部或部分液相组分供给至热分解反应釜的上部。
• PROCESS FOR PRODUCING ISOCYANATES USING DIARYL CARBONATE
  申请人：Shinohata Masaaki

  公开号：US20110054211A1

  公开（公告）日：2011-03-03

  An object of the present invention is to provide a process that enables isocyanate to be produced stably over a long period of time and at high yield without encountering problems of the prior art during production of isocyanate without using phosgene. The present invention provides an isocyanate production process including the steps of: obtaining a reaction mixture containing an aryl carbamate having an aryl group originating in a diaryl carbonate, an aromatic hydroxy compound originating in a diaryl carbonate, and a diaryl carbonate, by reacting a diaryl carbonate and an amine compound in the presence of a reaction solvent in the form of an aromatic hydroxy compound; transferring the reaction mixture to a thermal decomposition reaction vessel; and obtaining isocyanate by applying the aryl carbamate to a thermal decomposition reaction, wherein the reaction vessel in which the reaction between the diaryl carbonate and the amine compound is carried out and the thermal decomposition reaction vessel for the aryl carbamate are different.

  本发明的一个目的是提供一种能够在生产异氰酸酯时在长时间内稳定地且高产率地生产异氰酸酯的方法，而不使用光气时遇到先前技术问题的方法。本发明提供了一种异氰酸酯生产方法，包括以下步骤：通过在反应溶剂形式的芳香羟基化合物存在下，通过反应二芳基碳酸酯和胺化合物得到含有源自二芳基碳酸酯的芳基碳酸酯、源自二芳基碳酸酯的芳香羟基化合物和二芳基碳酸酯的反应混合物；将反应混合物转移至热分解反应容器；通过将芳基碳酸酯应用于热分解反应来获得异氰酸酯，其中进行二芳基碳酸酯和胺化合物之间的反应的反应容器和用于芳基碳酸酯的热分解反应的反应容器是不同的。
• Dynamic Induction of Optical Activity in Triarylmethanols and Their Carbocations
  作者：Bartosz Stasiak、Agnieszka Czapik、Marcin Kwit

  DOI：10.1021/acs.joc.0c02289

  日期：2021.1.1

  A series of artificial triarylmethanols has been synthesized and studied toward the possibility of exhibiting an induced optical activity. The observed chiroptical response of these compounds resulted from the chiral conformation of a triarylmethyl core. The chirality induction from a permanent chirality element to the liable triarylmethyl core proceeds as a cooperative and cascade process. The OH···O(R)

  合成了一系列的人造三芳基甲醇，并研究了其表现出诱导的光学活性的可能性。这些化合物的观察到的手性响应是由三芳基甲基核心的手性构象引起的。从永久手性元素到易反应的三芳基甲基核心的手性诱导以协同和级联过程进行。邻位OH···O（R）和/或（H）O···H碳氢键的形成以及C–H···π相互作用似乎是控制手性诱导效率的最重要因素。在三苯甲基骨架中的手性和甲氧基给电子基团的位置影响所观察到的棉花效应的幅度和三苯甲基碳正离子的稳定性。在中性环境中，邻位观察到最强烈的棉花效应取代的衍生物，在酸化时会经历快速分解，而分解后的ECD信号会完全消失。从所有原位产生的稳定碳正离子中，只有两个在450 nm左右的低能量区域表现出强烈的Cotton效应。碳正离子的形成是可逆的；碱化后，离子恢复为原始的中性形式。与迄今为止已知的大多数三芳基甲基衍生物不同，在晶体中，被手性部分对位取代的三芳基甲醇显示出固态分选现象的倾向。
• Synthesis of the 9-mesityl-10-phenyl-9-boraanthracene anion
  作者：R. van Veen、F. Bickelhaupt

  DOI：10.1016/s0022-328x(00)81597-1

  日期：1972.10

  Derivatives of 10-phenyl-9,10-dihydro-9-boraanthracene were synthesized from tris(2-benzhydrylphenyl)boroxin by pyrolysis with lithium aluminum hydride and tributyl borate. 10-Phenyl-9-boraanthracene could not be obtained from a chemical reaction or on electron impact. The isolation of lithium 9-mesityl-10-phenyl-9-boraanthracene as a crystalline non-solvated salt is described.

  通过氢化铝锂和硼酸三丁酯的热解，由三（2-苯甲酰基苯基）环硼氧烷合成10-苯基-9,10-二氢-9-硼蒽的衍生物。通过化学反应或电子撞击无法获得10-苯基-9-硼烷蒽。描述了作为结晶非溶剂化盐的锂9-间苯甲基-10苯基-9-硼烷蒽的分离。