| 17158-63-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• CAS: 17158-63-3
• 化学式: C6H15NNaO3
• 分子量: 172.18
• InChiKey: CKJGHPBOPQNPHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.12
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  63.9
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Aqueous foam containing chlorine dioxide and preparation and use thereof
  申请人：RIO LINDA CHEMICAL COMPANY, INC.

  公开号：EP0175826A1

  公开（公告）日：1986-04-02

  57 An aqueous solution, preferably an aqueous disinfectant solution, containing chlorine dioxide and which is capable of forming a foam, and methods for the preparation and use thereof. An aqueous disinfectant solution capable of forming a foam is prepared by adding a foaming agent, i.e., a suitable surfactant, to water. Chlorine dioxide may then be added to the solution or it may be generated in situ by reacting an oxidizing agent, a cationic exchange resin in the acidic form, or an acid with a metal chlorite dissolved therein. The resultant foam solution may subsequently be foamed by being mixed with air in a foam generator. The foam solutions of the instant invention are useful as cleaning and/or sanitizing agents.

  57 一种含有二氧化氯并能形成泡沫的水溶液，最好是消毒剂水溶液，及其制备和使用方法。在水中加入起泡剂，即适当的表面活性剂，即可制备出能够形成泡沫的消毒剂水溶液。然后可以向溶液中添加二氧化氯，或者通过氧化剂、酸性阳离子交换树脂或酸与溶解在其中的金属亚氯酸盐反应，就地生成二氧化氯。生成的泡沫溶液随后可在泡沫发生器中与空气混合发泡。本发明的泡沫溶液可用作清洁剂和/或消毒剂。
• Human chondroitinase glycoprotein (chasegp), process for preparing the same, and pharmaceutical compositions comprising thereof
  申请人：Halozyme, Inc.

  公开号：EP2218779A1

  公开（公告）日：2010-08-18

  The invention relates to the discovery of a novel Chondroitinase Glycoproteins (CHASEGP's), methods of manufacture, and potential uses in conditions where removal of chondroitin sulfates may be of therapeutic benefit. Chondroitinase Glycoproteins require both a substantial portion of the catalytic domain of the CHASEGP polypeptide and asparagine-linked glycosylation for optimal chondroitinase activity. The invention also includes carboxy-terminal deletion variants of CHASEGP that result in secreted variants of the protein to facilitate manufacture of a recombinant CHASEGP. Further described are suitable formulations of a substantially purified recombinant CHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.; CHASEGP is useful for the degradation of glycosaminoglycans and chondroitin sulfate proteoglycans under clinical conditions where their removal is of therapeutic value.

  本发明涉及一种新型软骨素酶糖蛋白（CHASEGP's）的发现、制造方法以及在去除软骨素硫酸盐可能有治疗效果的情况下的潜在用途。软骨素酶糖蛋白需要 CHASEGP 多肽催化结构域的大部分和天冬酰胺连接的糖基化，以获得最佳的软骨素酶活性。本发明还包括 CHASEGP 的羧基末端缺失变体，这些变体可形成该蛋白的分泌型变体，以方便制造重组 CHASEGP。本发明还描述了从真核细胞中提取的基本纯化的重组 CHASEGP 糖蛋白的合适制剂，该制剂可产生其最佳活性所需的适当糖基化。
• Composition and method for treating wounds and inflammatory conditions
  申请人：Exeltis USA Dermatology, Inc.

  公开号：US10034959B2

  公开（公告）日：2018-07-31

  Provided, among other things, is a method of treating skin and soft tissue wounds, ulcers, burns, various types of dermatoses, inflammatory conditions of the mucosa, and the like comprising: periodically applying to the wound, inflammatory condition of mucosal tissues, or dermatoses, over a course of days an effective amount of water based formulation (comprising: 0.5 to 5 wt % of an emollient comprising silicone oil, 2 to 10 wt % of fatty acid, humectant(s), emulsifying agent(s), and polymer(s)), wherein the formulation is formulated as a spray, cream, lotion, milk or foam-former.

  除其他外，还提供了一种治疗皮肤和软组织伤口、溃疡、烧伤、各种皮肤病、粘膜炎症等的方法，该方法包括：在数天内定期向伤口、粘膜组织炎症或皮肤病处涂抹有效量的水基配方（包括：0.5-5 wt % 的润肤剂（由硅油组成）、2-10 wt % 的脂肪酸、保湿剂和聚合物）：0.5 至 5 wt % 的润肤剂，包括硅油、2 至 10 wt % 的脂肪酸、保湿剂、乳化剂和聚合物），其中该配方被配制成喷雾剂、膏霜、乳液、乳剂或发泡剂。
• Econazole composition and methods of treatment therewith
  申请人：Hensby Christopher N.

  公开号：US10071054B2

  公开（公告）日：2018-09-11

  The invention provides a water-based composition for treating an infection by a dermatophyte fungus comprising econazole or a pharmaceutically acceptable salt thereof. Also provided are methods of treatment utilizing the water-based foam composition, as well as its preparation.

  本发明提供了一种用于治疗皮癣真菌感染的水基组合物，该组合物包含益康唑或其药学上可接受的盐。本发明还提供了利用水基泡沫组合物进行治疗的方法及其制备方法。
• Use of a cyclodextrin as pearlescent agent and pearlescent compositions
  申请人：——

  公开号：US20040033984A1

  公开（公告）日：2004-02-19

  Use of at least one agent chosen from cyclodextrins and the derivatives thereof as a pearlescent agent, in a composition, for example, a pearlescent cosmetic composition, comprising a physiologically acceptable aqueous medium. Use of at least one agent chosen from cyclodextrins and the derivatives thereof and at least one surfactant in compositions. Pearlescent compositions comprising, a physiologically acceptable aqueous medium, at least one agent chosen from cyclodextrins and the derivatives thereof, at least one surfactant, and at least one conditioning agent; as well as use of at least one agent chosen from cyclodextrins and the derivatives thereof as an agent for suspending an insoluble conditioning agent; wherein the compositions disclosed herein may be used in a form chosen, for example, from rinse-out products, for example, for washing and/or conditioning a keratinous material.

  在包含生理上可接受的水性介质的组合物（例如珠光化妆品组合物）中，使用至少一种选自环糊精及其衍生物的制剂作为珠光剂。在组合物中使用至少一种选自环糊精及其衍生物的制剂和至少一种表面活性剂。珠光组合物，包括生理上可接受的水性介质、至少一种选自环糊精及其衍生物的制剂、至少一种表面活性剂和至少一种调理剂；以及至少一种选自环糊精及其衍生物的制剂作为悬浮不溶性调理剂的制剂的用途；其中本文公开的组合物可以例如从冲洗产品中选择的形式使用，例如用于洗涤和/或调理角质材料。