N-[2-(4-hydroxyphenyl)ethyl]sulfuric diamide | 1375959-10-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-[2-(4-hydroxyphenyl)ethyl]sulfuric diamide
• 英文别名: 1-Hydroxy-4-[2-(sulfamoylamino)ethyl]benzene；1-hydroxy-4-[2-(sulfamoylamino)ethyl]benzene
• CAS: 1375959-10-6
• 化学式: C₈H₁₂N₂O₃S
• 分子量: 216.261
• InChiKey: IFWPBWLVIAEWSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  对羟基苯乙胺 在 盐酸 、 1-aza-4-azoniabicyclo[2.2.2]octan-4-ylsulfonyl(tert-butoxycarbonyl)azanido 1,4-diazabicyclo[2.2.2]octane monohydrochloride 作用下， 以 1,4-二氧六环 、 乙腈 、 水 为溶剂， 反应 3.0h， 生成 N-[2-(4-hydroxyphenyl)ethyl]sulfuric diamide 、 4-(2-(sulfamoylamino)ethyl)phenyl sulfamate
  参考文献：
  名称：

  N-(tert-Butoxycarbonyl)-N-[(triethylenediammonium)sulfonyl]azanide: A Convenient Sulfamoylation Reagent for Alcohols

  摘要：

  A convenient and efficient procedure is described for the sulfamoylation of alcohols using N-(tertbutoxycarbonyl)-N-[(triethylenediammonium)sulfonyl]azanide (1). The ambient temperature stable reagent 1 reacts with phenols as well as primary and secondary alcohols to give high to modest yields. The relative reaction rate of substrates was determined (primary > phenol > secondary tertiary). The reagent's utility as a selective sulfamoylation reagent with polyols is also demonstrated.

  DOI：

  10.1021/ol3009683

文献信息

• <i>N</i>-(<i>tert</i>-Butoxycarbonyl)-<i>N</i>-[(triethylenediammonium)sulfonyl]azanide: A Convenient Sulfamoylation Reagent for Alcohols
  作者：Ian Armitage、Alexander M. Berne、Eric L. Elliott、Mingkun Fu、Frederick Hicks、Quentin McCubbin、Lei Zhu

  DOI：10.1021/ol3009683

  日期：2012.5.18

  A convenient and efficient procedure is described for the sulfamoylation of alcohols using N-(tertbutoxycarbonyl)-N-[(triethylenediammonium)sulfonyl]azanide (1). The ambient temperature stable reagent 1 reacts with phenols as well as primary and secondary alcohols to give high to modest yields. The relative reaction rate of substrates was determined (primary > phenol > secondary tertiary). The reagent's utility as a selective sulfamoylation reagent with polyols is also demonstrated.