4,12-dihydroxyfluoranthene | 16255-99-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4,12-dihydroxyfluoranthene
• 英文别名: 3.9-Dihydroxy-fluoranthen；fluoranthene-3,9-diol；Fluoranthen-3,9-diol
• CAS: 16255-99-5
• 化学式: C₁₆H₁₀O₂
• 分子量: 234.254
• InChiKey: DFJZBURNMVGKEM-UHFFFAOYSA-N

物化性质

• 熔点：
  247-249 °C(Solv: xylene (1330-20-7))
• 沸点：
  505.2±23.0 °C(Predicted)
• 密度：
  1.474±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4,12-dihydroxyfluoranthene 在 硫酸 、 对甲苯磺酸 作用下， 反应 6.5h， 生成 acetic acid,4-methoxyfluoranthen-8-ol
  参考文献：
  名称：

  Azarov, A. S.; Shenbor, M. I.; Zaichenko, N. L., Journal of Organic Chemistry USSR (English Translation), 1983, vol. 19, # 8, p. 1523 - 1530

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 作用下， 生成 4,12-dihydroxyfluoranthene
  参考文献：
  名称：

  Hydroxy fluoranthenes

  摘要：

  公开号：

  US01990018A1

文献信息

• Pharmaceutically useful nitrogen containing heterocyclic derivatives
  申请人：Richardson-Merrell Inc.

  公开号：US03937833A1

  公开（公告）日：1976-02-10

  Bis-basic substituted aromatic polycyclic compounds of the following structure are useful in treating conditions of delayed hypersensitivity: ##SPC1## Wherein [W] represents an aromatic polycyclic nucleus selected from fluoranthene, fluorene, fluoren-9-ol, fluoren-9-one, dibenzofuran, dibenzothiophene, carbazole, N-(lower)alkyl carbazole, xanthene, xanthone, thioxanthene, phenoxathiin, or anthraquinone; Y represents carbonyloxy, carbonylthio, oxygen, divalent sulfur or carbonyl with the provisos that when Y is carbonyloxy or carbonylthio, [W] is other than thioxanthene, phenoxathiin or anthraquinone, when Y is oxygen or divalent sulfur, [W] is other than thioxanthene or phenoxathiin, and when Y is carbonyl, [W] is other than fluoren-9-ol or anthraquinone; A represents a straight or branched alkylene chain of from 1 to 6 carbon atoms with the proviso that when Y is carbonyloxy or carbonylthio, A contains at least 2 straight chain carbon atoms, that is, an ethylene radical; R represents hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, phenyl or benzyl; and pharmaceutically useful acid addition salts.

  以下结构的Bis-基取代芳香族多环化合物在治疗延迟型超敏反应方面很有用：##SPC1## 其中[W]代表从荧蒽、芴、芴-9-醇、芴-9-酮、二苯并呋喃、二苯并噻吩、咔唑、N-(较低)烷基咔唑、苯酚氧噻吩或蒽醌中选的芳香族多环核；Y代表羰氧基、羰硫基、氧、二价硫或羰基，但当Y为羰氧基或羰硫基时，[W]不是噻吩、苯酚氧噻吩或蒽醌，当Y为氧或二价硫时，[W]不是噻吩或苯酚氧噻吩，当Y为羰基时，[W]不是芴-9-醇或蒽醌；A代表1至6个碳原子的直链或支链烷基链，但当Y为羰氧基或羰硫基时，A含有至少2个直链碳原子，即乙烯基；R代表氢、1至4个碳原子的直链或支链低级烷基、苯基或苄基；以及药用酸盐。
• Pharmaceutically useful bis-amine derivatives
  申请人：Richardson-Merrell Inc.

  公开号：US03947593A1

  公开（公告）日：1976-03-30

  Compounds of the following general structure are useful in treating conditions of delayed hypersensitivity: ##EQU1## wherein [W] represents an aromatic polycyclic nucleus selected from fluoranthene, fluorene, fluoren-9-ol, fluoren-9-one, carbazole, N-(lower) alkyl carbazole or anthraquinone; Y represents carbonyl, divalent sulfur or oxygen; with the proviso that when Y is carbonyl, [W] is other than fluoren-9-ol or anthraquinone; A represents a straight or branched alkylene chain of from 1 to 6 carbon atoms; and each of R.sup.1 and R.sup.2 represents hydrogen, lower alkyl of from 1 to 4 carbon atoms, or alkenyl of from 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position; and pharmaceutically useful acid addition salts thereof.

  下列一般结构的化合物对于治疗延迟超敏反应的病症是有用的：##EQU1## 其中[W]代表从氟蒽、芴、芴-9-醇、芴-9-酮、咔唑、N-(较低)烷基咔唑或蒽醌中选取的芳香多环核；Y代表羰基、二价硫或氧；条件是当Y为羰基时，[W]不是芴-9-醇或蒽醌；A代表由1至6个碳原子组成的直链或支链烷基链；而且R1和R2中的每一个代表氢、由1至4个碳原子的低烷基或由3至6个碳原子且具有乙烯基不饱和度但不在1-位置上的烯基；以及其药学上有用的酸盐。
• Bis-basic-substituted polycyclic aromatic compounds. New class of antiviral agents. 6. Bis-basic-substituted fluoranthenes
  作者：William L. Albrecht、Robert W. Fleming、Stephen W. Horgan、Barbara A. Deck、Jake W. Hoffmann、Gerald D. Mayer

  DOI：10.1021/jm00257a005

  日期：1974.11
• DE575953
  申请人：——

  公开号：——

  公开（公告）日：——
• The orientation of disubstituted fluoranthene derivatives
  作者：Neil Campbell、N. H. Keir

  DOI：10.1039/jr9550001233

  日期：——