cholic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: cholic acid
• 英文别名: (4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
• 化学式: C₂₄H₄₀O₅
• 分子量: 408.579
• InChiKey: BHQCQFFYRZLCQQ-OQUYUCHYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  cholic acid 在 吡啶 、 aluminum oxide 作用下， 反应 29.0h， 生成 3α-Ethoxycarbonyloxy-5β-chola-7,11-diensaeure-methylester
  参考文献：
  名称：

  来自脱氧胆酸和胆酸的胆酸系列烯烃

  摘要：

  部分脱水从脱氧胆酸产生两种新的烯烃，从胆酸产生五种。

  DOI：

  10.1002/ardp.19813140205

文献信息

• [EN] 3-HYDROXY-4-OXO-1,2,3-TRIAZINES AND DERIVATIVES THEREOF FOR AMIDE AND ESTER BOND FORMATION<br/>[FR] 3-HYDROXY-4-OXO-1,2,3-TRIAZINES ET LEURS DERIVES POUR LA FORMATION DE LIAISONS AMIDE ET ESTER
  申请人：FRUTAROM LTD

  公开号：WO2005007634A1

  公开（公告）日：2005-01-27

  The present invention relates to the use of a compound of formula I as a coupling reagent in forming amide or ester bonds from a reaction between a carboxylic acid and an amine or an alcohol, respectively. The compounds of formula I are especially useful as coupling reagents in the preparation of peptide bonds during peptide synthesis. In particular, the compounds of formula I are useful in promoting the formation of reactive reaction intermediates, inhibiting side reactions and in suppression of racemization. In addition, the present invention provides novel compounds of Formula I, and salts of N-oxides thereof.

  本发明涉及在羧酸与胺或醇之间的反应中，将式I化合物用作偶联试剂形成酰胺或酯键。式I化合物在肽合成过程中特别有用作为偶联试剂。具体来说，式I化合物有助于促进反应中间体的形成，抑制副反应和消除旋光异构化。此外，本发明提供了式I的新化合物及其N-氧化物盐。
• First bile acid-derived chiral dendritic species with nanometric dimensions
  作者：R. Balasubramanian、Photon Rao、U. Maitra

  DOI：10.1039/a907297g

  日期：——

  This paper describes the first synthesis of branched bile acid oligomers.

  本文介绍了支链胆汁酸低聚物的首次合成。
• Conductive material and substrate
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US10023752B2

  公开（公告）日：2018-07-17

  The present invention provides a conductive material including: (A) a π-conjugated polymer, (B) a dopant polymer which contains one or more repeating units selected from “a1” to “a4” respectively shown by the following general formula (1) and has a weight-average molecular weight in the range of 1,000 to 500,000, and (C) one or more salts selected from the group consisting of a monovalent copper salt of carboxylic acid, a monovalent copper salt of β-diketone, and a monovalent copper salt of β-ketoester. There can be provided a conductive material that has excellent film-formability and also can form a conductive film having high transparency and conductivity, superior flexibility and flatness when the film is formed from the material.

  本发明提供了一种导电材料，包括(A) π-共轭聚合物；(B) 掺杂聚合物，其含有一个或多个如下通式(1)所示分别选自 "a1 "至 "a4 "的重复单元，且其重量平均分子量在 1,000 至 500,000 之间；以及 (C) 一种或多种盐，其选自由羧酸的一价铜盐、β-二酮的一价铜盐和β-酮酯的一价铜盐组成的组。本发明可提供一种导电材料，该材料具有优异的成膜性，并可形成具有高透明度和导电性的导电薄膜，在由该材料形成薄膜时，还具有优异的柔韧性和平整度。
• Resist composition and patterning process
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：US10222696B2

  公开（公告）日：2019-03-05

  A resist composition comprising a base polymer and a biguanide salt compound offers a high dissolution contrast, minimal LWR, and dimensional stability on PPD.

  由基质聚合物和双胍盐化合物组成的抗蚀剂组合物在 PPD 上具有较高的溶解对比度、最小的 LWR 和尺寸稳定性。
• Process for the enzymatic regeneration of redox cofactors
  申请人：ANNIKKI GMBH

  公开号：US10370691B2

  公开（公告）日：2019-08-06

  A process for the enzymatic regeneration of the redox cofactors NAD+/NADH and NADP+/NADPH in a one-pot reaction, wherein, as a result of at least two further enzymatically catalyzed redox reactions proceeding in the same reaction batch (product-forming reactions), one of the two redox cofactors accumulates in its reduced form and, respectively, the other one in its oxidized form, characterized in that a) in the regeneration reaction which reconverts the reduced cofactor into its original oxidized form, oxygen or a compound of general formula R1C(O)COOH is reduced, and b) in the regeneration reaction which reconverts the oxidized cofactor into its original reduced form, a compound of general formula R2CH(OH)R3 is oxidized and wherein R1, R2 and R3 in the compounds have different meanings.

  一种在单锅反应中用酶再生氧化还原辅助因子 NAD+/NADH 和 NADP+/NADPH 的工艺，其中，由于在同一批反应（生成物反应）中进行了至少两个酶催化的氧化还原反应，两种氧化还原辅助因子中的一种以其还原形式积累，另一种分别以其氧化形式积累、其特征在于：a) 在将还原型辅助因子重新转化为原始氧化型的再生反应中，氧或通式 R1C(O)COOH 的化合物被还原；b) 在将氧化型辅助因子重新转化为原始还原型的再生反应中，通式 R2CH(OH)R3 的化合物被氧化，其中化合物中的 R1、R2 和 R3 具有不同的含义。