Cholsaeure

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Cholsaeure
• 英文别名: 4-[(10S,13R)-10,13-dimethyl-3,7,12-tris(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid；4-[(10S,13R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
• 化学式: C₂₄H₄₀O₅
• 分子量: 408.579
• InChiKey: BHQCQFFYRZLCQQ-ZAZBRUGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Amphiphilic heparin derivative formed by coupling a heparin with a bile acid
  申请人：Hoarau Didier

  公开号：US20070141158A1

  公开（公告）日：2007-06-21

  The invention relates to an amphiphilic heparin derivative formed from at least one type of partially N-desulfated heparin and at least one type of bile acid comprising one or several bile acid molecules grafted on a heparin molecule by an amide bond formed between the terminal carboxylic acid function of a bile acid and a primary heparin amine function which is initially present in the heparin or resulting from the N-desulfation. The inventive derivative is characterized in that the number of grafted bile acid molecules per 100 heparin disaccharide units ranges from 15 to 80 approximately.

  本发明涉及一种两性异相性肝素衍生物，由至少一种部分N-去硫化肝素和至少一种胆汁酸组成，其中通过酰胺键形成胆汁酸末端羧酸功能与肝素末端胺基功能之间的结合，将一个或多个胆汁酸分子嫁接到肝素分子上。该衍生物的特点在于，每100个肝素二糖单位嫁接的胆汁酸分子数约为15至80个。