1,1,2,2,3,3-Hexamethylguanidiniumbromid | 6926-43-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,1,2,2,3,3-Hexamethylguanidiniumbromid
• 英文别名: Hexamethylguanidiniumbromid；N,N,N',N'-Tetramethyl-guanidinium；Bis(dimethylamino)methylidene-dimethylazanium;bromide
• CAS: 6926-43-8
• 化学式: Br*C₇H₁₈N₃
• 分子量: 224.144
• InChiKey: UOPTWCQTDMKUHE-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.26
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  9.5
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  hexamethylguanidinium-azide 在 溴乙酸乙酯 作用下， 以 二氯甲烷 为溶剂， 生成 1,1,2,2,3,3-Hexamethylguanidiniumbromid
  参考文献：
  名称：

  Synthesis and Azidolysis of 2-Chlorotetramethylguanidine. Synthetic Utility of Hexa- and Tetramethylguanidinium Azide

  摘要：

  DOI：

  10.1021/jo01343a026

文献信息

• Halogen exchange reactions and catalysts therefor
  申请人：——

  公开号：US20030163000A1

  公开（公告）日：2003-08-28

  An essentially anhydrous agitated mixture of (i) finely-divided essentially anhydrous alkali metal fluoride (e.g., KF), (ii) haloaromatic compound having at least one halogen atom of atomic number greater than 9 on an aromatic ring (e.g., C 6 Cl 6 ), and (iii) an organo guanidinium salt catalyst (e.g., [(Et 2 N) 2 CNEt 2 ]Br), is heated at a temperature at which fluorine replaces one or more of the ring halogen atoms of the haloaromatic compound. A new synthetic route to hexahydrocarbyl guanidinium salts is also described.

  本发明涉及一种基本无水的搅拌混合物，包括（i）细分粉末的基本无水碱金属氟化物（例如KF），（ii）在芳香环上具有原子序数大于9的至少一个卤素原子的卤代芳香化合物（例如C6Cl6），以及（iii）一种有机胍盐催化剂（例如（Et2N）2CNEt2Br），在氟原子取代卤代芳香化合物的一个或多个环卤素原子的温度下加热。本发明还描述了一种新的合成六氢烷基胍盐的方法。
• A Process for imparting low compression set to liquid injection moldable silicone elastomers
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0926190A1

  公开（公告）日：1999-06-30

  A process to reduce the compression set of elastomeric silicone compositions, addition cured injection moldable compositions or millable compositions, comprises the incorporation of nitrogen compounds wherein the nitrogen possesses at least one organic substituent and the nitrogen is tetravalent wherein the nitrogen is cationic.

  一种降低弹性硅树脂组合物、加成固化注射成型组合物或研磨组合物压缩永久变形的工艺，包括加入氮化合物，其中氮具有至少一个有机取代基，氮为四价，氮为阳离子。
• Curable silicone elastomers having primerless adhesion
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0926207A1

  公开（公告）日：1999-06-30

  The compression set of elastomeric silicone compositions, addition cured injection moldable compositions or millable compositions, is reduced by the incorporation of nitrogen compounds wherein the nitrogen possesses at least one organic substituent and the nitrogen is tetravalent wherein the nitrogen is cationic. The adhesion of such compositions to thermoset or thermoplastic polymer substrates is improved by the addition of bis(trimethoxysilylpropyl)fumarate and a disilanol that may or may not contain alkenyl groups.

  通过加入氮化合物（其中氮具有至少一个有机取代基，氮为四价，氮为阳离子），可降低弹性硅树脂组合物、加成固化注射成型组合物或研磨组合物的压缩永久变形。通过添加双（三甲氧基硅丙基）富马酸酯和二硅烷醇（可含或不含烯基），可提高此类组合物与热固性或热塑性聚合物基材的粘附性。
• Liquid injection molding silicone elastomers having primerless adhesion
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP0939101A2

  公开（公告）日：1999-09-01

  The compression set of elastomeric silicone compositions, addition cured injection moldable compositions, is reduced by the incorporation of nitrogen compounds wherein the nitrogen possesses at least one organic substituent and the nitrogen is tetravalent wherein the nitrogen is cationic. The adhesion of such compositions to thermoset or thermoplastic polymer substrates is improved by the addition of bis(trimethoxysilylpropyl)fumarate and a disilanol that may or may not contain alkenyl groups. The lubricity of such compositions is improved by the addition of compounds selected from the group consisting of diorganosiloxanes such as polydimethylsiloxanes, phenyl containing siloxanes such as copolymers of diphenylsiloxane with diorganosiloxanes and copolymers of methylphenylsiloxane with diorganosiloxanes, fluorosilicones such as silicones containing trifluoropropyl substituted siloxanes, polydimethylsiloxanes, aliphatic and aromatic hydrocarbons that are liquid between 0 °C and 100 °C without adversely affecting the adhesion of the composition.

  通过加入含氮化合物（其中氮至少具有一个有机取代基）和四价氮（其中氮为阳离子），可降低弹性硅树脂组合物和固化注射成型组合物的压缩永久变形。通过添加双（三甲氧基硅丙基）富马酸酯和二硅烷醇（可含或不含烯基），可改善此类组合物与热固性或热塑性聚合物基材的粘附性。添加选自以下组别的化合物可改善此类组合物的润滑性：二甘醇硅氧烷，如聚二甲基硅氧烷；含苯基硅氧烷，如二苯基硅氧烷与二甘醇硅氧烷的共聚物；甲基苯基硅氧烷与二甘醇硅氧烷的共聚物、含氟硅酮，如含三氟丙基取代硅氧烷的硅酮、聚二甲基硅氧烷、脂肪族和芳香族碳氢化合物，它们在 0 °C 至 100 °C 之间呈液态，不会对组合物的粘附性产生不利影响。
• Chemical processes
  申请人：Rhone Poulenc Agro

  公开号：EP0994099A1

  公开（公告）日：2000-04-19

  The invention relates to a process for the preparation of a compound of formula (I): wherein: R1 represents C1-4 haloalkyl, fluorine, chlorine or bromine; and R2 represents hydrogen or C1-4 alkoxy; which process comprises the reaction of the corresponding ortho-nitrobromobenzene of formula (II): wherein R1 and R2 are as hereinbefore defined, with: (a)cuprous cyanide optionally in the presence of a catalyst selected from an alkali metal bromide or an alkaline earth metal bromide; or (b) an alkali metal cyanide in the presence of a catalytic amount of cuprous cyanide and a phase transfer catalyst.

  本发明涉及一种制备式 (I) 化合物的工艺： 其中 R1代表C1-4卤代烷基、氟、氯或溴；R2代表氢或C1-4烷氧基；该工艺包括相应的式(II)邻硝基溴苯的反应： 其中 R1 和 R2 如前定义，与下列物质反应 (a) 可选择在选自碱金属溴化物或碱土金属溴化物的催化剂存在下的氰化亚铜；或 (b) 碱金属氰化物在催化量的氰化亚铜和相转移催化剂存在下。