2-(4-hydroxy-1-naphthyl)acetic acid | 3812-95-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(4-hydroxy-1-naphthyl)acetic acid
• 英文别名: (4-hydroxy-[1]naphthyl)-acetic acid；(4-Hydroxy-[1]naphthyl)-essigsaeure；2-(4-Hydroxynaphthalen-1-yl)acetic acid
• CAS: 3812-95-1
• 化学式: C₁₂H₁₀O₃
• 分子量: 202.21
• InChiKey: KZLJZTJKEGCVJJ-UHFFFAOYSA-N

物化性质

• 熔点：
  192-194 °C
• 沸点：
  110-140 °C(Press: 0.01 Torr)
• 密度：
  1.353±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-hydroxy-1-naphthyl)acetic acid 、 硫酸二甲酯 生成 (4-甲氧基萘-1-基)-乙酸
  参考文献：
  名称：

  �ber die katalytische Hydrierung von Chinolen

  摘要：

  DOI：

  10.1007/bf00905414
• 作为产物：
  描述：

  (4-hydroxy-[1]naphthyl)-acetic acid ethyl ester 生成 2-(4-hydroxy-1-naphthyl)acetic acid
  参考文献：
  名称：

  �ber die katalytische Hydrierung von Chinolen

  摘要：

  DOI：

  10.1007/bf00905414

文献信息

• Method for producing a heterocyclic compound and an aromatic carboxylic acid having one or more hydroxyl groups, and modified aromatic ring dioxygenase
  申请人：——

  公开号：US20040086983A1

  公开（公告）日：2004-05-06

  An objective of the present invention is to provide a method of producing hydroxylated heterocyclic compounds and hydroxylated aromatic carboxylic acids by bioengineering technique, and modified enzymes which can be used for this method. A method of producing hydroxylated heterocyclic compounds or hydroxylated aromatic carboxylic acids comprises reacting an aromatic ring dioxygenase with heterocyclic compounds or aromatic carboxylic acids to hydroxylate these compounds. An enzyme according to the present invention is an aromatic ring dioxygenase comprising an &agr;-subunit consisting of the amino acid sequence of SEQ ID NO: 2, which is modified according to the &agr;-subunit of the biphenyl dioxygenase derived from the strain Burkholderia cepacia LB400, a &bgr;-subunit consisting of the amino acid sequence of SEQ ID NO: 4, and a ferredoxin consisting of the amino acid sequence of SEQ ID NO: 6, and a ferredoxin reductase consisting of the amino acid sequence of SEQ ID NO: 8.

  本发明的目的是提供一种通过生物工程技术生产羟基化杂环化合物和羟基化芳香族羧酸的方法，以及可用于该方法的改良酶。生产羟基化杂环化合物或羟基化芳香族羧酸的方法包括使芳香环二加氧酶与杂环化合物或芳香族羧酸反应，使这些化合物羟基化。根据本发明的一种酶是一种芳香环二加氧酶，它包括一个由 SEQ ID NO: 2 的氨基酸序列组成的&agr;-亚基，它是根据从菌株中得到的联苯二加氧酶的&agr;-亚基修饰的 伯克霍尔德氏菌 LB400，由 SEQ ID NO: 4 的氨基酸序列组成的&bgr;-亚基，由 SEQ ID NO: 6 的氨基酸序列组成的铁毒素，以及由 SEQ ID NO: 8 的氨基酸序列组成的铁毒素还原酶。
• [EN] HIGH WATER-REDUCING AND LOW SENSITIVITY POLYCARBOXYLATE SUPERPLASTICIZER AND PREPARATION METHOD THEREFOR<br/>[FR] SUPERPLASTIFIANT À BASE DE POLYCARBOXYLATE HAUTEMENT RÉDUCTEUR D'EAU ET À FAIBLE SENSIBILITÉ ET SON PROCÉDÉ DE PRÉPARATION<br/>[ZH] 一种高减水低敏感聚羧酸减水剂及其制备方法
  申请人：KZJ NEW MAT GROUP CO LTD

  公开号：WO2019233215A1

  公开（公告）日：2019-12-12

  本发明公开了一种高减水低敏感聚羧酸减水剂及其制备方法，其分子量为10000～150000，且其结构式如下：本发明通过将不饱和聚醚单体和化合物A的酯化产物用于聚羧酸减水剂的合成在聚羧酸减水剂分子的支链末端引入了苯环及羧基结构，苯环结构使得聚羧酸减水剂分子支链的空间位阻效应得到了增强，羧基结构使得聚羧酸减水剂分子支链不仅具有空间位阻效应，还具有静电斥力效应，使得制备的聚羧酸减水剂减水率更高。
• Hydroxylation of ionized aromatics including carboxylic acid or amine using recombinant Streptomyces lividans cells expressing modified biphenyl dioxygenase genes
  作者：Kazutoshi Shindo、Ryoko Nakamura、Ikuko Chinda、Yasuo Ohnishi、Sueharu Horinouchi、Haruko Takahashi、Kazuo Iguchi、Shigeaki Harayama、Kensuke Furukawa、Norihiko Misawa

  DOI：10.1016/s0040-4020(03)00180-7

  日期：2003.3

  The bphA1(2072)A2A3A4 gene cluster codes for a shuffled biphenyl dioxygenase holoenzyme with broad substrate specificity. These bphA1(2072)A2A3A4 genes were expressed in the actinomycetes Streptomyces lividans using a thiostrepton-inducible promoter P(tipA). Biotransformation experiments of various aromatics including carboxylic acid or amine in their molecular structure, such as 1-naphthoic acid, 2-(1-naphthyl)acetic acid, diphenylamine, and 1-benzyl-4-piperidone, were performed using the recombinant S. lividans cells. These ionized aromatics were converted to the corresponding 1,2-dihydrodiol, mono- or tri-hydroxy forms in 48 h. The structure of the converted products was determined by their EI-MS, (1)H- and (13)C NMR analysis, and several products were found to be novel compounds. (C) 2003 Elsevier Science Ltd. All rights reserved.
• Intramolecular acylation. Part V. Preparation and ring closure of some methoxy-1-naphthyl-acetic, -propionic, -butyric, and -α-ethylglutaric acids
  作者：A. L. Green、D. H. Hey

  DOI：10.1039/jr9540004306

  日期：——
• The Chemistry of 1-Naphthaleneacetic Acid Derivatives
  作者：Yoshiro Ogata、Masaya Okano、Yasuo Kitamura

  DOI：10.1021/jo50004a015

  日期：1951.10