(3-Chloro-2,2-dimethyl-propyl)-dimethyl-amine | 90050-17-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (3-Chloro-2,2-dimethyl-propyl)-dimethyl-amine
• 英文别名: (3-Chlor-2,2-dimethyl-propyl)-dimethyl-amin；3-Chlor-1-dimethylamino-2.2-dimethyl-propan；3-Dimethylamino-2,2-dimethyl-propylchlorid；3-chloro-N,N,2,2-tetramethylpropan-1-amine
• CAS: 90050-17-2
• 化学式: C₇H₁₆ClN
• mdl: MFCD19232016
• 分子量: 149.664
• InChiKey: XNWULQTXTJXEFU-UHFFFAOYSA-N

物化性质

• 沸点：
  142 °C(Press: 12 Torr)
• 密度：
  0.919±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (3-Chloro-2,2-dimethyl-propyl)-dimethyl-amine 在 乙醇 、 异丙醇 作用下， 生成 (3-benziloyloxy-2,2-dimethyl-propyl)-trimethyl-ammonium; bromide
  参考文献：
  名称：

  Synthetic Mydriatics. III

  摘要：

  DOI：

  10.1021/ja01250a045
• 作为产物：
  描述：

  1,1,3,3-tetramethyl-azetidinium; chloride 生成 (3-Chloro-2,2-dimethyl-propyl)-dimethyl-amine
  参考文献：
  名称：

  Mannich; Baumgarten, Chemische Berichte, 1937, vol. 70, p. 210,213

  摘要：

  DOI：

文献信息

• Triazolone derivatives
  申请人：Clark Richard

  公开号：US20080015199A1

  公开（公告）日：2008-01-17

  A Compound represented by the following general formula (1), salts thereof or hydrates of the foregoing is a novel compound useful for treatment and/or prevention of diseases associated with thrombus formation, and which is safer with suitable physicochemical stability. [wherein R 1a , R 1b , R 1c and R 1d each independently represent hydrogen, etc.; R 2 represents optionally substituted phenyl, etc.; R 3 represents optionally substituted C6-10 aryl, etc.; and Z 1 and Z 2 each independently represent hydrogen]

  以下一般式（1）表示的化合物，其盐或上述化合物的水合物是一种新型化合物，可用于治疗和/或预防与血栓形成相关的疾病，并且具有适当的物理化学稳定性，更安全。 [其中R1a，R1b，R1c和R1d分别独立表示氢等；R2表示可选择取代的苯基等；R3表示可选择取代的C6-10芳基等；Z1和Z2分别独立表示氢]
• Process for the manufacture of basic esters of phenyl substituted fatty acids
  申请人：HOFFMANN LA ROCHE

  公开号：US01987546A1

  公开（公告）日：1935-01-08

  Fatty-aromatic esters of amino-alcohols are prepared by treating a compound of the formula <;FORM:0413599/IV/1>; in which R represents an alkyl or hydrogen, R<;1>;, R<;2>; and R<;3>; signifies alkyl (R<;2>; and R<;3>; together with the nitrogen atom may comprise a heterocyclic ring), and X stands for halogen, with a salt of a fatty-aromatic acid. Examples are given of the interaction of (1) 3-piperidino-2 : 2-dimethyl-propyl chloride and potassium tropate; (2) 3 - diethylamino - 2 : 2 - dimethyl - propyl chloride and potassium tropate, sodium d-tropate or potassium mandelate. 3 - Piperidino - 2 : 2 - dimethyl - propyl chloride is obtained by reducing a a -dimethyl-b -piperidino-propionaldehyde (see Specification 348,382) with sodium amalgam and treating the alcohol with thionyl chloride. Amino-alkyl halides of the formula given above are prepared by treating the amino-alcohols whose preparation is described in the parent Specification with halogenating agents such as thionyl chloride.

  通过使用脂肪芳香酸盐处理公式为R表示烷基或氢，R1，R2和R3表示烷基（R2和R3与氮原子一起可以构成杂环环）和X代表卤素的化合物，制备了氨基醇的脂肪芳香酯。给出了以下反应的示例：（1）3-哌啶基-2：2-二甲基丙基氯化物和曲酸钾；（2）3-二乙氨基-2：2-二甲基丙基氯化物和曲酸钾，d-曲酸钠或曼德酸钾。 3-哌啶基-2：2-二甲基丙基氯化物通过还原α-二甲基-β-哌啶基丙醛（参见规范348,382）并用亚硫酰氯处理醇来获得。给定的上述公式的氨基烷卤化物通过使用亚硫酰氯等卤化试剂处理在父规范中描述的氨基醇制备。
• TRIAZOLONE DERIVATIVES
  申请人：CLARK Richard

  公开号：US20100190783A1

  公开（公告）日：2010-07-29

  A Compound represented by the following general formula (1): wherein R 1a , R 1b , R 1c and R 1d each independently represent hydrogen, etc.; R 2 represents optionally substituted phenyl, etc.; R 3 represents optionally substituted C6-10 aryl, etc.; and Z 1 and Z 2 each independently represent hydrogen or salts thereof or hydrates of the foregoing.

  以下是通式（1）表示的化合物：其中R1a，R1b，R1c和R1d各自独立地表示氢等；R2表示可选取代的苯基等；R3表示可选取代的C6-10芳基等；Z1和Z2各自独立地表示氢或其盐或其水合物。
• TRIAZOLONE DERIVATIVE
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP2000465A1

  公开（公告）日：2008-12-10

  A Compound represented by the following general formula (1), salts thereof or hydrates of the foregoing is a novel compound useful for treatment and/or prevention of diseases associated with thrombus formation, and which is safer with suitable physicochemical stability. [wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc.; R2 represents optionally substituted phenyl, etc.; R3 represents optionally substituted C6-10 aryl, etc.; and Z1 and Z2 each independently represent hydrogen]

  由以下通式（1）代表的化合物、其盐类或前述化合物的水合物是一种新型化合物，可用于治疗和/或预防与血栓形成有关的疾病，且具有较高的安全性和适当的理化稳定性。 [其中 R1a、R1b、R1c 和 R1d 各自独立地代表氢等；R2 代表任选取代的苯基等；R3 代表任选取代的 C6-10 芳基等；Z1 和 Z2 各自独立地代表氢］
• Triazolone derivative
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP2194046A1

  公开（公告）日：2010-06-09

  A Compound represented by the following general formula (1), salts thereof or hydrates of the foregoing is a novel compound useful for treatment and/or prevention of diseases associated with thrombus formation, and which is safer with suitable physicochemical stability. [wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc.; R2 represents optionally substituted phenyl, etc.; R3 represents optionally substituted C6-10 aryl, etc.; and Z1 and Z2 each independently represent hydrogen]

  由以下通式（1）代表的化合物、其盐类或前述化合物的水合物是一种新型化合物，可用于治疗和/或预防与血栓形成有关的疾病，且具有更高的安全性和适当的理化稳定性。 [其中 R1a、R1b、R1c 和 R1d 各自独立地代表氢等；R2 代表任选取代的苯基等；R3 代表任选取代的 C6-10 芳基等；Z1 和 Z2 各自独立地代表氢］