4-(6-spiro-1'-cyclopropane-1a,6-dihydro-1H-cyclopropa[a]inden-6a-yl)-1H-imidazole | 625836-09-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 4-(6-spiro-1'-cyclopropane-1a,6-dihydro-1H-cyclopropa[a]inden-6a-yl)-1H-imidazole
• 英文别名: 5-spiro[1,1a-dihydrocyclopropa[a]indene-6,1'-cyclopropane]-6a-yl-1H-imidazole
• CAS: 625836-09-1
• 化学式: C₁₅H₁₄N₂
• 分子量: 222.29
• InChiKey: FYLKUCQQWYKEOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (6-spiro-1'-cyclopropane-1a,6-dihydro-1H-cyclopropa[a]inden-6a-yl)-carboxaldehyde 、 对甲基苯磺酰甲基异腈 、 氰化钠 在 氨 作用下， 以 乙醇 、 甲醇 为溶剂， 反应 17.0h， 以28%的产率得到4-(6-spiro-1'-cyclopropane-1a,6-dihydro-1H-cyclopropa[a]inden-6a-yl)-1H-imidazole
  参考文献：
  名称：

  Novel imidazolic compounds, method for preparing same and use thereif as medicines

  摘要：

  这项发明提供具有以下化学式（1）的化合物：其中R1是氢、氟或甲氧基，R1位于芳香碳环的2、3、4或5位置；R2是氢或甲基；R3是氢、甲基或乙基；以及它们的药用可接受酸盐、药用可接受酸盐的水合物，以及它们的异构体和互变异构体。

  公开号：

  US20060041001A1

文献信息

• Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
  申请人：Vacher Bernard

  公开号：US20070197793A1

  公开（公告）日：2007-08-23

  The invention provides methods of treating a memory deficiency in a subject in need of such treatment, where the methods comprise administering to a subject an effective amount of a compound of formula (1): wherein: R1 is hydrogen, fluorine or a methoxyl group, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or a methyl group; R3 is hydrogen, a methyl group or an ethyl group; and their pharmaceutically acceptable acid addition salt as well as the isomers and the tautomers thereof. The memory deficiency may be correlated with a memory deficiency induced by scopolamine.
• IMIDAZOLIC COMPOUNDS AND USE THEREOF AS ALPHA-2 ADRENERGIC RECEPTORS
  申请人：Vacher Bernard

  公开号：US20110021589A1

  公开（公告）日：2011-01-27

  The invention provides methods of treating a memory deficiency in a subject in need of such treatment, where the methods comprise administering to a subject an effective amount of a compound of formula (1): wherein: R1 is hydrogen, fluorine or a methoxyl group, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or a methyl group; R3 is hydrogen, a methyl group or an ethyl group; and their pharmaceutically acceptable acid addition salt as well as the isomers and the tautomers thereof. The memory deficiency may be correlated with a memory deficiency induced by scopolamine.
• US7220866B2
  申请人：——

  公开号：US7220866B2

  公开（公告）日：2007-05-22
• US7776901B2
  申请人：——

  公开号：US7776901B2

  公开（公告）日：2010-08-17
• US8188126B2
  申请人：——

  公开号：US8188126B2

  公开（公告）日：2012-05-29