3'-Deoxyoleacein | 289030-99-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3'-Deoxyoleacein
• 英文别名: 2-(4-hydroxyphenyl)ethyl (Z)-4-formyl-3-(2-oxoethyl)hex-4-enoate
• CAS: 289030-99-5
• 化学式: C₁₇H₂₀O₅
• 分子量: 304.34
• InChiKey: VPOVFCBNUOUZGG-JLZUIIAYSA-N

物化性质

• 比旋光度：
  D25 -0.78° (c = 0.9 in chloroform)
• 沸点：
  500.1±50.0 °C(Predicted)
• 密度：
  1.165±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  80.7
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• WGK Germany：
  3
• 储存条件：
  -20°C

制备方法与用途

oleocanthal是一种苯乙醇苷，也属于天然酚类化合物，存在于初榨橄榄油中。它是一种酪醇酯，化学结构与同样存在于橄榄油中的橄榄苦苷类似。

文献信息

• [EN] USE OF PHENOLIC COMPOUNDS FROM OLEA EUROPAEA<br/>[FR] UTILISATION DE COMPOSÉS PHÉNOLIQUES ISSUS D'OLEA EUROPAEA
  申请人：MCCORD DARLENE E

  公开号：WO2019033010A1

  公开（公告）日：2019-02-14

  A series of phenolic compounds with similar inhibitory COX-1 and COX-2 properties as oleocanthal and oleuropein is described here. The phenolic compounds disclosed here were also found to be MAO and LSD-1 inhibitors. Also provided are methods of using these phenolic compounds in various formulations and compositions including food additives, pharmaceuticals, cosmetics, and animal repellants.

  本文描述了一系列具有类似于欧利可坦和欧洛普林的抑制COX-1和COX-2性质的酚类化合物。这些在此披露的酚类化合物也被发现是MAO和LSD-1的抑制剂。还提供了使用这些酚类化合物在各种配方和组合中的方法，包括食品添加剂、药品、化妆品和动物驱避剂。
• [EN] PROCESS FOR THE PRODUCTION OF OLEOCANTHAL, OLEACEIN AND THEIR ANALOGUES<br/>[FR] PROCÉDÉ DE PRODUCTION D'OLÉOCANTHAL, D'OLÉACEINE ET DE LEURS ANALOGUES
  申请人：NATIONAL AND KAPODISTRIAN UNIV OF ATHENS

  公开号：WO2021121925A1

  公开（公告）日：2021-06-24

  A process for the production of a compound according to Formula (I), such as oleocanthal or oleacein, starting from oleuropein. The process provides the dialdehyde core of oleocanthal, oleacein and their analogues having the required stereochemistry. Furthermore, the process can be used for the production of a large number of structurally diverse products by varying the structure of the alcohol moiety in the esterification step.

  根据公式(I)，从欧洲橄榄叶苷开始生产化合物的方法，例如欧力坎醇或欧力酮。该方法提供了欧力坎醇、欧力酮及其类似物所需立体化学结构的二醛核心。此外，通过在酯化步骤中改变醇基的结构，该方法可用于生产大量结构多样的产物。
• Method and system to reduce porosity in composite structures
  申请人：The Boeing Company

  公开号：EP2703429A1

  公开（公告）日：2014-03-05

  In an embodiment of the disclosure, there is provided a method to reduce porosity in a composite structure. The method adds an additive to a resin material to form an additive-resin mixture. The method combines the additive-resin mixture with reinforcement fibers to form a composite prepreg material, and in turn, a composite structure. The method heat cures the composite structure in a heating apparatus under a vacuum device at the resin cure temperature, heats the composite structure to an increased temperature above the additive phase transition temperature, and maintains the increased temperature for a time period sufficient. The method reduces the increased temperature back down to the resin cure temperature to allow the additive gas to undergo a phase transition to a condense phase, resulting in a substantially reduced vacuum pressure, resulting in a reduction in a porosity of the composite structure.

  在本公开的一个实施方案中，提供了一种减少复合材料结构中孔隙率的方法。该方法将添加剂添加到树脂材料中，形成添加剂-树脂混合物。该方法将添加剂-树脂混合物与增强纤维相结合，形成复合预浸料，进而形成复合结构。该方法在真空设备下的加热装置中，在树脂固化温度下对复合结构进行热固化，将复合结构加热到高于添加剂相变温度的升高温度，并在足够长的时间内保持该升高温度。该方法将升高的温度降至树脂固化温度，使添加剂气体发生相变，进入凝结相，从而使真空压力大大降低，导致复合材料结构的孔隙率降低。
• PROCESS FOR THE PRODUCTION OF OLEOCANTHAL, OLEACEIN AND THEIR ANALOGUES
  申请人：National and Kapodistrian University of Athens

  公开号：EP3838885A1

  公开（公告）日：2021-06-23

  A process for the production of a compound according to Formula (I), such as oleocanthal or oleacein, starting from oleuropein. The process provides the dialdehyde core of oleocanthal, oleacein and their analogues having the required stereochemistry. Furthermore, the process can be used for the production of a large number of structurally diverse products by varying the structure of the alcohol moiety in the esterification step.

  一种以油黄素为原料生产符合式 (I) 的化合物（如油黄醛或油菜素）的工艺。该工艺可提供具有所需立体化学结构的油菜醛、油菜素及其类似物的二醛核心。此外，通过改变酯化步骤中醇分子的结构，该工艺还可用于生产大量结构不同的产品。
• Method and System to Reduce Porosity in Composite Structures
  申请人：Humfeld Keith Daniel

  公开号：US20140060731A1

  公开（公告）日：2014-03-06

  In an embodiment of the disclosure, there is provided a method to reduce porosity in a composite structure. The method adds an additive to a resin material to form an additive-resin mixture. The method combines the additive-resin mixture with reinforcement fibers to form a composite prepreg material, and in turn, a composite structure. The method heat cures the composite structure in a heating apparatus under a vacuum device at the resin cure temperature, heats the composite structure to an increased temperature above the additive phase transition temperature, and maintains the increased temperature for a time period sufficient. The method reduces the increased temperature back down to the resin cure temperature to allow the additive gas to undergo a phase transition to a condense phase, resulting in a substantially reduced vacuum pressure, resulting in a reduction in a porosity of the composite structure.