Sebacoyldicholine diiodide | 17140-07-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Sebacoyldicholine diiodide
• 英文别名: trimethyl-[2-[10-oxo-10-[2-(trimethylazaniumyl)ethoxy]decanoyl]oxyethyl]azanium;diiodide
• CAS: 17140-07-7
• 化学式: C20H42I2N2O4
• 分子量: 628.4
• InChiKey: UAFKCVXOLXSYGP-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -3.39
• 重原子数：
  28
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
  申请人：NICOX OPHTHALMICS, INC.

  公开号：US10174071B2

  公开（公告）日：2019-01-08

  The present invention further provides method of preparing nanocrystals of a hydrophobic therapeutic agent such as fluticasone or triamcinolone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and/or preventing the signs and/or symptoms of disorders such as blepharitis, meibomian gland dysfunction or skin inflammation or a respiratory disease (e.g., asthma).

  本发明进一步提供了制备疏水性治疗剂（如氟替卡松或曲安西龙）纳米晶体的方法、其药物组合物（如局部或鼻内组合物）以及治疗和/或预防诸如睑缘炎、睑板腺功能障碍或皮肤炎症或呼吸系统疾病（如哮喘）等疾病的症状和/或体征的方法。
• PREPARATIONS OF HYDROPHOBIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE AND USE THEREOF
  申请人：Aciex Therapeutics, Inc.

  公开号：EP2941437A1

  公开（公告）日：2015-11-11
• Preparations of Hydrophobic Therapeutic Agents, Methods of Manufacture and Use Thereof
  申请人：ACIEX THERAPEUTICS, INC.

  公开号：US20130303502A1

  公开（公告）日：2013-11-14

  The present invention further provides method of preparing nanocrystals of a hydrophobic therapeutic agent such as fluticasone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and/or preventing the signs and/or symptoms of disorders such as blepharitis, meibomian gland dysfunction or skin inflammation or a respiratory disease (e.g., asthma).
• US8765725B2
  申请人：——

  公开号：US8765725B2

  公开（公告）日：2014-07-01
• US9815865B2
  申请人：——

  公开号：US9815865B2

  公开（公告）日：2017-11-14