4,4'-diamino-2,2'-stilbenedisulfonic acid appears as odorless yellowish microscopic needles or cream-colored powder. pH approximately 4.3 at 30 g/L water (suspension). (NTP, 1992)
颜色/状态：
YELLOW NEEDLES
熔点：
greater than 617 °F (NTP, 1992)
溶解度：
less than 1 mg/mL at 73° F (NTP, 1992)
计算性质
辛醇/水分配系数(LogP)：
0.3
重原子数：
24
可旋转键数：
4
环数：
2.0
sp3杂化的碳原子比例：
0.0
拓扑面积：
178
氢给体数：
4
氢受体数：
8
ADMET
毒理性
副作用
职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒案例。
Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
RESULTS OF MEDICAL SURVEYS & STUDIES ON SAFETY OF FLUORESCENT WHITENING AGENTS (FWA'S) CONTAINING DIAMINOSTILBENE DISULFONATE WERE COMPILED & CRITICIZED. CONCLUSION THAT FWA'S ARE PRACTICALLY NONTOXIC.
4,4'-Diamino-2,2'-stilbenedisulfonic acid was evaluated for mutagenicity in the Salmonella/microsome preincubation assay using a standard protocol approved by the National Toxicology Program. Doses of 0, 100, 333, 3333, 4000, 4500, and 5000 ug/plate were tested in four Salmonella typhimurium strains (TA98, TA100, TA1535, and TA1537) in the presence and absence of Aroclor-induced rat or hamster liver S9. These tests were negative and the highest ineffective dose level tested in any Salmonella tester strain was 5000 ug/plate.
The invention relates to novel bis(triazinylamino)stilbenes which are suitable as UV absorbers and fluorescent whiteners for textile materials and also bring about an increase in the treated textile material.
NOVEL COMPOUND HAVING MULTIMER STRUCTURE OF XANTHENE DERIVATIVE, COLORING COMPOSITION, INK FOR INKJET RECORDING, METHOD OF INKJET RECORDING, COLOR FILTER, AND COLOR TONER
申请人：FUJIFILM CORPORATION
公开号：US20140176653A1
公开（公告）日：2014-06-26
There is provided a compound represented by formula (1):
in formula (1), L represents a divalent to tetravalent linking group; D represents a residue obtained by removing 1 to 5 hydrogen atoms from a compound represented by formula (2); m represents an integer of 1 to 10, however, each L may be the same with or different from every other L; n represents an integer of 2 to 10, however, each D may be the same with or different from every other D; and in formula (2), each of R
4
to R
24
independently represents a hydrogen atom or a substituent, provided that formula (2) has at least one or more ionic hydrophilic groups.
[EN] WATER SOLUBLE AND WATER FAST DYES FOR INK JET PRINTING<br/>[FR] COLORANTS HYDROSOLUBLES ET SOLIDES À L'EAU POUR L'IMPRESSION PAR JET D'ENCRE
申请人：ILFORD IMAGING CH GMBH
公开号：WO2013139485A1
公开（公告）日：2013-09-26
The invention relates to azo dyes of desulfo-K-acid [CA: 35400-55-6], their salts, a method for the preparation of these dyes, or salts thereof, a liquid phase comprising at least one of these dyes, a method for applying the liquid phase on a substrate, a printed matter and the use of these dyes in water-based inks for inkjet printing, in writing utensil or dyeing solutions for manufacturing color filters for optical and opto-electronic applications.
HIV protease inhibitors useful for the treatment of aids
申请人：MERCK & CO. INC.
公开号：EP0534511A1
公开（公告）日：1993-03-31
Compounds of the form,
A-G-J
wherein A is an amine protecting group or urethane, G a dipeptide isostere and J a small terminal group are described. They are distinguished by tetrahydrofuryl or tetrahydropyranyl substituents, and the like. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
