4-(4-Bromonaphthalen-1-yl)-2-methylbut-3-yn-2-ol | 1383726-22-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(4-Bromonaphthalen-1-yl)-2-methylbut-3-yn-2-ol
• 英文别名: 4-(4-bromonaphthalen-1-yl)-2-methylbut-3-yn-2-ol
• CAS: 1383726-22-4
• 化学式: C₁₅H₁₃BrO
• 分子量: 289.172
• InChiKey: RBXXDZSWTCTZGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(4-Bromonaphthalen-1-yl)-2-methylbut-3-yn-2-ol 在 甲醇 、 四(三苯基膦)钯 、 三乙胺 、 sodium hydroxide 作用下， 以 四氢呋喃 、 苯 为溶剂， 生成
  参考文献：
  名称：

  Design and synthesis of phosphorylated pyridine-based ligands for lanthanide complexation. Part 1

  摘要：

  Several new ligands constructed from a pyridine-ethynylnaphthalene platform have been engineered with a chelating pocket comprising bisdimethylaminocarboxylate/phosphonate or bisdimethylaminophosphonate units. Selective hydrolysis provides pockets with four to six anionic carboxylate or phosphate functions suitable for lanthanide complexation. Linkage at the opposite side of a flexible hanging arm either via a triple bond or through an amide tether offers the possibility of further use of these ligands for bio-conjugation. Protocols to link the dedicated pockets via hydrophilic flexible chain to Biotin are also detailed. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.04.105
• 作为产物：
  描述：

  1,4-二溴代萘 、 2-甲基-3-丁炔-2-醇 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 二异丙胺 作用下， 以 四氢呋喃 为溶剂， 以35%的产率得到4-(4-Bromonaphthalen-1-yl)-2-methylbut-3-yn-2-ol
  参考文献：
  名称：

  Design and synthesis of phosphorylated pyridine-based ligands for lanthanide complexation. Part 1

  摘要：

  Several new ligands constructed from a pyridine-ethynylnaphthalene platform have been engineered with a chelating pocket comprising bisdimethylaminocarboxylate/phosphonate or bisdimethylaminophosphonate units. Selective hydrolysis provides pockets with four to six anionic carboxylate or phosphate functions suitable for lanthanide complexation. Linkage at the opposite side of a flexible hanging arm either via a triple bond or through an amide tether offers the possibility of further use of these ligands for bio-conjugation. Protocols to link the dedicated pockets via hydrophilic flexible chain to Biotin are also detailed. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.04.105

文献信息

• LUMINESCENT PROBES FOR BIOLOGICAL LABELING AND IMAGING, METHOD FOR PREPARING SAME
  申请人：UNIVERSITE DE STRASBOURG

  公开号：US20140228553A1

  公开（公告）日：2014-08-14

  The present invention relates to organic compounds that are usable as ligands for preparing complexes of lanthanides or of certain transition metals which are water-soluble, to a method for preparing same, and also to the use thereof as a fluorescent probe.

  本发明涉及作为配体用于制备镧系元素或某些过渡金属的水溶性配合物的有机化合物，涉及制备方法以及将其用作荧光探针的用途。
• US9388202B2
  申请人：——

  公开号：US9388202B2

  公开（公告）日：2016-07-12
• [EN] LUMINESCENT PROBE FOR BIOLOGICAL LABELLING AND IMAGING, METHOD FOR PREPARING SAME<br/>[FR] SONDES LUMINESCENTES POUR LE MARQUAGE BIOLOGIQUE ET L'IMAGERIE, LEUR PROCEDE DE PREPARATION
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2013054046A1

  公开（公告）日：2013-04-18

  La présente invention concerne des composés organiques, utilisables comme ligands pour la préparation de complexes de lanthanides ou de certains métaux de transition solubles dans l'eau, un procédé pour leur préparation, ainsi que leur utilisation à titre de sonde fluorescente.
• Design and synthesis of phosphorylated pyridine-based ligands for lanthanide complexation. Part 1
  作者：Raymond Ziessel、Alexandre Steffen、Matthieu Starck

  DOI：10.1016/j.tetlet.2012.04.105

  日期：2012.7

  Several new ligands constructed from a pyridine-ethynylnaphthalene platform have been engineered with a chelating pocket comprising bisdimethylaminocarboxylate/phosphonate or bisdimethylaminophosphonate units. Selective hydrolysis provides pockets with four to six anionic carboxylate or phosphate functions suitable for lanthanide complexation. Linkage at the opposite side of a flexible hanging arm either via a triple bond or through an amide tether offers the possibility of further use of these ligands for bio-conjugation. Protocols to link the dedicated pockets via hydrophilic flexible chain to Biotin are also detailed. (C) 2012 Elsevier Ltd. All rights reserved.