isobutylenediamine | 868139-74-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: isobutylenediamine
• 英文别名: ibn；Diamino-2-methylpropane；2-methylpropane-1,1-diamine
• CAS: 868139-74-6
• 化学式: C₄H₁₂N₂
• 分子量: 88.1527
• InChiKey: RJOFSHRKXGENSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  potassium tetrachloroplatinate(II) 、 isobutylenediamine 、 potassium iodide 以 水 为溶剂， 反应 0.58h， 生成
  参考文献：
  名称：

  系列阳离子双核Pt(II)配合物的体外和体内活性

  摘要：

  [{Pt( L )Cl} 2 ( μ -X)] 2+类型的九种双核铂(II)配合物的抗肿瘤潜力（其中L代表两个NH 3或不同的双齿配位二胺配体-乙二胺，en；（ ±)-1,2-丙二胺，1,2-pn；异丁二胺，ibn；反式-(±)-1,2-二氨基环己烷，dach；1,3-丙二胺，2,2-二甲基； -1,3-丙二胺，2,2-diMe-1,3-pd；(±)-1,3-戊二胺，1,3-pnd，X是桥联吡嗪(pz)或哒嗪(pydz)配体）通过使用 CT26 细胞系和在免疫活性 BALB/c 小鼠中诱导的异位结肠癌肿瘤小鼠模型进行体外和体内测定来确定。本研究得出的结论是，复合物Pt1 、 Pt2和Pt7对小鼠结肠癌CT26细胞具有显着的体外细胞毒活性，同时所有这些复合物都显示出中等的细胞凋亡作用。复合物Pt1和Pt7将CT26细胞阻滞在细胞周期的G2/M期，而通过检测Ki67表达细胞进行评估，复合物Pt

  DOI：

  10.1016/j.jinorgbio.2021.111619

文献信息

• Easy synthesis of ‘half-units’: their use as ligands or as precursors of non-symmetrical Schiff base complexes
  作者：Jean-Pierre Costes、Maria Isabel Fernandez-Garcia

  DOI：10.1016/0020-1693(95)04641-l

  日期：1995.9

  This paper is devoted to a particular reaction able to give singly condensed Schiff base derivatives of beta-diketones (called 'half-units') in an easy way. Indeed, 1,2-diamino-2-methylpropane, which possesses an amine function sterically hindered by two methyl groups, reacts with a diketone such as 2,4-pentanedione or 2-hydroxyacetophenone only by its non-hindered amine function, yielding a 'half-unit'. In a following step, this terdentate ligand can react with an aldehyde function to give a non-symmetrical tetradentate Schiff base. Such a reaction can be performed on the free 'half-unit' or on its 'complexed form'. Some examples of nickel and copper complexes are given. A particular interest has been given to the use of imidazole-2-carboxaldehyde which yields non-symmetrical Schiff base complexes with a free nitrogen atom not included in the N3O coordination site. According to the procedure of 'complexes as ligands', it is possible to isolate bimetallic complexes with imidazole bridges. Their genuine identity has been confirmed by NMR (nickel) and also by thermal variation of the magnetic susceptibility (copper).
• In vitro and in vivoactivity of series of cationic dinuclearPt(II) complexes
  作者：Ivana Vasić、Snežana Rajković、Aleksandar Arsenijević、Marija Milovanović、Nebojša Arsenijević、Jelena Milovanović、Marija D. Živković

  DOI：10.1016/j.jinorgbio.2021.111619

  日期：2021.12

  expressing cells, complexes Pt5 and Pt6 exerted the highest antiproliferative effect. Complexes Pt1 and Pt2 exerted significant in vivo antitumour effects. These complexes reduced the growth of primary tumour and the incidence of lung and liver metastases without causing the significant hepato- and nephro- toxicity. Our data indicate considerable antitumour activity of platinum(II) complexes against CT26

  [Pt( L )Cl} 2 ( μ -X)] 2+类型的九种双核铂(II)配合物的抗肿瘤潜力（其中L代表两个NH 3或不同的双齿配位二胺配体-乙二胺，en；（ ±)-1,2-丙二胺，1,2-pn；异丁二胺，ibn；反式-(±)-1,2-二氨基环己烷，dach；1,3-丙二胺，2,2-二甲基； -1,3-丙二胺，2,2-diMe-1,3-pd；(±)-1,3-戊二胺，1,3-pnd，X是桥联吡嗪(pz)或哒嗪(pydz)配体）通过使用 CT26 细胞系和在免疫活性 BALB/c 小鼠中诱导的异位结肠癌肿瘤小鼠模型进行体外和体内测定来确定。本研究得出的结论是，复合物Pt1 、 Pt2和Pt7对小鼠结肠癌CT26细胞具有显着的体外细胞毒活性，同时所有这些复合物都显示出中等的细胞凋亡作用。复合物Pt1和Pt7将CT26细胞阻滞在细胞周期的G2/M期，而通过检测Ki67表达细胞进行评估，复合物Pt