methyl 2-prop-2-enyl-2H-chromene-3-carboxylate | 1010721-87-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: methyl 2-prop-2-enyl-2H-chromene-3-carboxylate
• CAS: 1010721-87-5
• 化学式: C₁₄H₁₄O₃
• 分子量: 230.263
• InChiKey: GQSMQLGIZAJFAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  methyl 2-[(4-methylphenyl)sulfonylamino]-2H-chromene-3-carboxylate 、 烯丙基三甲基硅烷 在 四氯化钛 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 3.0h， 以23 mg的产率得到methyl 2-prop-2-enyl-2H-chromene-3-carboxylate
  参考文献：
  名称：

  Three-Component Coupling Reaction and Cyclization of N-Tosylimines and TMS-Substituted Propiolate Mediated by DABCO

  摘要：

  [GRAPHICS]A new three-component coupling reaction of methyl 3-trimethylsilylpropiolate, N-tosylimine, and tosylamide mediated by DABCO was developed. This reaction was based on the consecutive alpha- and beta-activation method of propiolate involving intramolecular silyl migration previously developed by our group. On the basis of these results, a new cyclization reaction was designed to find a chrome ne-formin g reaction utilizing salicyl N-tosylimine as a bifunctional substrate.

  DOI：

  10.1021/jo702649q

文献信息

• Three-Component Coupling Reaction and Cyclization of <i>N</i>-Tosylimines and TMS-Substituted Propiolate Mediated by DABCO
  作者：Yuji Matsuya、Kousuke Hayashi、Akiho Wada、Hideo Nemoto

  DOI：10.1021/jo702649q

  日期：2008.3.1

  [GRAPHICS]A new three-component coupling reaction of methyl 3-trimethylsilylpropiolate, N-tosylimine, and tosylamide mediated by DABCO was developed. This reaction was based on the consecutive alpha- and beta-activation method of propiolate involving intramolecular silyl migration previously developed by our group. On the basis of these results, a new cyclization reaction was designed to find a chrome ne-formin g reaction utilizing salicyl N-tosylimine as a bifunctional substrate.