indocyanine green | 28782-33-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: indocyanine green
• 英文别名: ICG；4-[(2Z)-2-[(2E,4E,6Z)-7-[1,1-dimethyl-3-(4-sulfobutyl)benzo[e]indol-3-ium-2-yl]hepta-2,4,6-trienylidene]-1,1-dimethylbenzo[e]indol-3-yl]butane-1-sulfonate
• CAS: 28782-33-4
• 化学式: C₄₃H₄₈N₂O₆S₂
• 分子量: 752.996
• InChiKey: BDBMLMBYCXNVMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  53
• 可旋转键数：
  13
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  135
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  indocyanine green 在 sodium acetate 作用下， 以 乙醇 为溶剂， 反应 0.5h， 以85.9%的产率得到indocyanine green
  参考文献：
  名称：

  一种吲哚菁绿及其制备方法与应用

  摘要：

  本发明提供一种吲哚菁绿及其制备方法与应用，该吲哚菁绿如式1所示，所述方法按说明书记载的路线进行，该路线主要是以2,3,3‑三甲基‑4,5‑苯并吲哚2、1,4‑丁基磺酸内酯及2‑戊烯二醛二缩苯胺盐酸盐为原料合成了目标化合物式1所示的吲哚菁绿。该方法合成路线短、工艺简单、无需贵重金属的催化、产率高，符合“绿色化学”发展的要求；

  公开号：

  CN106631979A
• 作为产物：
  描述：

  1,1,2-三甲基苯-1H-苯并[e]吲哚 在 三乙胺 作用下， 以 乙醇 、 甲苯 为溶剂， 反应 4.75h， 生成 indocyanine green
  参考文献：
  名称：

  一种吲哚菁绿及其制备方法与应用

  摘要：

  本发明提供一种吲哚菁绿及其制备方法与应用，该吲哚菁绿如式1所示，所述方法按说明书记载的路线进行，该路线主要是以2,3,3‑三甲基‑4,5‑苯并吲哚2、1,4‑丁基磺酸内酯及2‑戊烯二醛二缩苯胺盐酸盐为原料合成了目标化合物式1所示的吲哚菁绿。该方法合成路线短、工艺简单、无需贵重金属的催化、产率高，符合“绿色化学”发展的要求；

  公开号：

  CN106631979A

文献信息

• Additive manufacturing using photothermal dyes for high efficiency sintering
  申请人：Lee Chang-Uk

  公开号：US11014293B2

  公开（公告）日：2021-05-25

  Methods, processes, and systems for the manufacture of three-dimensional articles made of polymers using 3D printing are provided. A layer of high performance polymer can be deposited on a build plate to form a powder bed. Then, a solution of a photothermal dye can be printed on the powder bed in a predetermined pattern. Alternatively, the photothermal dye can be added to the entire powder bed. Electromagnetic radiation can be applied, either to the entire bed or in a predetermined pattern, to form the final polymer. After a predetermined period of time, sequential layers are printed to provide the three-dimensional article. The three-dimensional object can be cured to produce the three-dimensional article composed of the final polymers.

  本文提供了利用三维打印技术制造聚合物三维物品的方法、工艺和系统。可以在构建板上沉积一层高性能聚合物，形成粉末床。然后，将光热染料溶液按预定图案打印在粉末床上。或者，也可以将光热染料添加到整个粉末床上。在整个粉末床上或以预定的模式进行电磁辐射，以形成最终的聚合物。经过一段预定的时间后，连续的层被打印出来，形成三维物体。三维物体可以固化，以生产由最终聚合物组成的三维物品。
• Microbubble-chemotherapeutic agent complex for sonodynamic therapy
  申请人：UNIVERSITY OF ULSTER

  公开号：US11382987B2

  公开（公告）日：2022-07-12

  The invention relates to methods of sonodynamic therapy comprising the co-administration of a microbubble-chemotherapeutic agent complex together with a microbubble-sonosensitiser complex. It further relates to pharmaceutical compositions comprising these complexes and their use in methods of sonodynamic therapy and/or sonodynamic diagnosis. Such methods find particular use in the treatment of cancer, e.g. pancreatic cancer.

  本发明涉及声动力治疗方法，包括同时施用微气泡-化学治疗剂复合物和微气泡-声敏剂复合物。本发明还涉及包含这些复合物的药物组合物及其在声动力治疗和/或声动力诊断方法中的应用。这些方法特别适用于癌症，如胰腺癌的治疗。
• N-alkylated linear heptamethine polyenes as potent non-azole leads against Candida albicans fungal infections
  作者：Clare L. Lawrence、Adeyi Okoh Okoh、Vinod Vishwapathi、Sean T. McKenna、Megan E. Critchley、Robert B. Smith

  DOI：10.1016/j.bioorg.2020.104070

  日期：2020.9

  In this study, eighteen heptamethine dyes were synthesised and their antifungal activities were evaluated against three clinically relevant yeast species.. The eighteen dyes were placed within classes based on their core subunit i.e. 2,3,3-trimethylindolenine (5a-f), 1,1,2-trimethyl-1H-benzo[e]indole (6a-f), or 2-methylbenzothiazole (7a-f). The results presented herein imply that the three families of cyanine dyes, in particular compounds 5a-f, show high potential as selective scaffolds to treat C. albicans infections. This opens up the opportunity for further optimisation and investigation of this class compounds for potential antifungal treatment.
• Additive Manufacturing Using Photothermal Dyes for High Efficiency Sintering
  申请人：Lee Chang-Uk

  公开号：US20190275735A1

  公开（公告）日：2019-09-12

  Methods, processes, and systems for the manufacture of three-dimensional articles made of polymers using 3D printing are provided. A layer of high performance polymer can be deposited on a build plate to form a powder bed. Then, a solution of a photothermal dye can be printed on the powder bed in a predetermined pattern. Alternatively, the photothermal dye can be added to the entire powder bed. Electromagnetic radiation can be applied, either to the entire bed or in a predetermined pattern, to form the final polymer. After a predetermined period of time, sequential layers are printed to provide the three-dimensional article. The three-dimensional object can be cured to produce the three-dimensional article composed of the final polymers.
• SONODYNAMIC THERAPY
  申请人：UNIVERSITY OF ULSTER

  公开号：US20200114003A1

  公开（公告）日：2020-04-16

  The invention relates to microbubble complexes for use in methods of sonodynamic therapy which comprise a microbubble attached to or otherwise associated with one or more linking groups, each linking group being bound to at least one sonosensitising agent and at least one chemotherapeutic agent. It further relates to the microbubble complexes themselves and to pharmaceutical compositions which contain them. The invention is particularly suitable for the treatment of deep-sited tumors, in particular pancreatic cancer.