Ergotamini tartras | 379-79-3

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 麦角林及其衍生物
• 英文名称: Ergotamini tartras
• 英文别名: (6aR,9R)-N-[(1S,2S,4R,7S)-7-benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide;2,3-dihydroxybutanedioic acid
• CAS: 379-79-3
• 化学式: C70H76N10O16
• 分子量: 1313.4
• InChiKey: CJMJLDQKTOJACI-SEUSHGJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.86
• 重原子数：
  96
• 可旋转键数：
  11
• 环数：
  16.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  352
• 氢给体数：
  10
• 氢受体数：
  18

文献信息

• DIRECTED DIFFERENTIATION OF OLIGODENDROCYTE PRECURSOR CELLS TO A MYELINATING CELL FATE
  申请人：The Scripps Research Institute

  公开号：EP2675893A1

  公开（公告）日：2013-12-25
• [EN] DIRECTED DIFFERENTIATION OF OLIGODENDROCYTE PRECURSOR CELLS TO A MYELINATING CELL FATE<br/>[FR] DIFFÉRENCIATION DIRIGÉE DE CELLULES PRÉCURSEURS D'OLIGODENDROCYTES VERS UN DESTIN CELLULAIRE MYÉLINISANT
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2012112933A1

  公开（公告）日：2012-08-23

  The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.