D-sphingosine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: D-sphingosine
• 英文别名: (Z)-2-aminooctadec-4-ene-1,3-diol
• 化学式: C₁₈H₃₇NO₂
• 分子量: 299.497
• InChiKey: WWUZIQQURGPMPG-PFONDFGASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  21
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-苯基乙基异硫代氰酸酯 、 D-sphingosine 以 甲醇 为溶剂， 反应 48.0h， 以87%的产率得到1-[(Z)-1,3-dihydroxyoctadec-4-en-2-yl]-3-(2-phenylethyl)thiourea
  参考文献：
  名称：

  Antitumour activity of sphingoid base adducts of phenethyl isothiocyanate

  摘要：

  N-(N'-Phenethylthiocarbamoyl) derivatives of sphingosine and sphinganine were prepared. They had antitumour activity: GC(50) values of 0.64 +/- 0.02 mu M (N = 18) and 1.6 +/- 0.01 mu M (N = 18), respectively, with human leukaemia 60 cells in vitro. This antitumour effect may contribute to the suppression of carcinogenesis associated with dietary phenethyl isothiocyanate and sphingolipid bases. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00574-0

文献信息

• PHOTOSYNTHETIC MICROORGANISMS ENRICHED IN SELENIUM USING SELENOHYDROXY ACID COMPOUNDS, USED THEREOF IN NUTRITION, COSMETICS AND PHARMACY
  申请人：Kudla Bernard

  公开号：US20110165658A1

  公开（公告）日：2011-07-07

  The invention relates to the enrichment of photosynthetic microorganisms in organic selenium using selenohydroxy acid compounds, in particular 2-hydroxy-4-methylselenobutanoic acid, in D or L form, or an enantiomer, salt or ester or amide derivative of these compounds, and also to the use of the microorganisms thus enriched in animal or human nutrition, in cosmetics or in pharmacy.
• NON-PHOTOSYNTHETIC MICRO-ORGANISMS ENRICHED WITH ORGANIC SELENIUM FROM SELENO-HYDROXYACID COMPOUNDS AND APPLICATIONS THEREOF IN THE FIELDS OF NUTRITION, COSMETICS AND PHARMACUEUTICALS
  申请人：Yadan Jean-Claude

  公开号：US20110151545A1

  公开（公告）日：2011-06-23

  The invention relates to the enrichment of non-photosynthetic micro-organisms with organic selenium, and more particularly with selenomethionine, from a compound of the seleno-hydroxyacid type such as 2-hydroxy-4-methylseleno-butanoic acid in the (D, L) form or in the form of an enantiomer, salt, ester, or amide derivative of said compound, and to the use of micro-organisms, particularly bacteria thus enriched in the fields of animal or human nutrition, cosmetics, or pharmaceuticals.
• US8535931B2
  申请人：——

  公开号：US8535931B2

  公开（公告）日：2013-09-17
• US9017985B2
  申请人：——

  公开号：US9017985B2

  公开（公告）日：2015-04-28
• Antitumour activity of sphingoid base adducts of phenethyl isothiocyanate
  作者：Ke Xu、Paul J. Thornalley

  DOI：10.1016/s0960-894x(99)00574-0

  日期：2000.1

  N-(N'-Phenethylthiocarbamoyl) derivatives of sphingosine and sphinganine were prepared. They had antitumour activity: GC(50) values of 0.64 +/- 0.02 mu M (N = 18) and 1.6 +/- 0.01 mu M (N = 18), respectively, with human leukaemia 60 cells in vitro. This antitumour effect may contribute to the suppression of carcinogenesis associated with dietary phenethyl isothiocyanate and sphingolipid bases. (C) 1999 Elsevier Science Ltd. All rights reserved.