WNN1711-F004 | 135463-11-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: WNN1711-F004
• 英文别名: (4Z)-2-hydroxy-4-[(4-hydroxyanilino)methylidene]cyclohexa-2,5-dien-1-one；4-[(4-hydroxyphenyl)iminomethyl]benzene-1,2-diol
• CAS: 135463-11-5
• 化学式: C₁₃H₁₁NO₃
• 分子量: 229.235
• InChiKey: BPPUBTDIFQTARU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  73
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对氨基苯酚 、 3,4-二羟基苯甲醛 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 以50%的产率得到WNN1711-F004
  参考文献：
  名称：

  新型氮杂-白藜芦醇类似物：针对乳腺癌细胞系的合成、表征和抗癌活性

  摘要：

  新的 Aza-白藜芦醇类似物被合成、结构表征和评估对 MDA-MB-231 和 T47D 乳腺癌细胞系的细胞毒活性，其表现出优于母体白藜芦醇化合物的抑制活性。这些化合物与雌激素受体-α 的结合机制通过分子对接研究进行了合理化，表明额外的氢结合相互作用和蛋白质腔中的紧密结合。在用新合成的白藜芦醇类似物处理后，乳腺癌细胞系中 Beclin-1 蛋白表达的诱导表明这些细胞系通过自噬抑制了生长。

  DOI：

  10.1016/j.bmcl.2012.12.002

文献信息

• A Simple and Highly Sensitive Turn-on Schiff Base Type Naked-eye Fluorescent Sensor for Aluminum Ion in Living Cells
  作者：Sedat Keskin、Mevlut Bayrakci

  DOI：10.17344/acsi.2018.4755

  日期：——

  Six different Schiff bases to be used as turn-on fluorescent probes based on photoinduced electron transfer (PET) mechanism for the recognition of aluminum ions were successfully synthesized and characterized. The binding abilities of synthesized compounds with different metal cations were investigated by absorption and emission spectra. From the spectrophotometric experiments, it were seen that compound SK-1 displayed an excellent fluorescence response towards targeted aluminum ions probably due to its suitable chelating structure. Furthermore, such compound SK-1 also showed high sensitivity and selectivity response towards aluminum ions over other competing ions. In addition, the potential biological applications of SK-1 to detect aluminum ions in living cells were also investigated and results showed that fluorescence sensor SK-1 could be a promising probe for determining and/or monitoring aluminum ions in both biological and/or chemical samples.
• Novel Aza-resveratrol analogs: Synthesis, characterization and anticancer activity against breast cancer cell lines
  作者：Areej Siddiqui、Prasad Dandawate、Rukhsana Rub、Subhash Padhye、Shama Aphale、Alpana Moghe、Amrit Jagyasi、K. Venkateswara Swamy、Bhupendra Singh、Anwesha Chatterjee、Amruta Ronghe、Hari K. Bhat

  DOI：10.1016/j.bmcl.2012.12.002

  日期：2013.2

  expression in breast cancer cell lines after treatment with newly synthesized resveratrol analogs indicated inhibition of growth of these cell lines through autophagy. The study highlighted the advantage of introducing the imino-linkage in resveratrol motif in enhancing the anticancer potential of resveratrol suggesting that these analogs can serve as better therapeutic agents against breast cancer and can

  新的 Aza-白藜芦醇类似物被合成、结构表征和评估对 MDA-MB-231 和 T47D 乳腺癌细胞系的细胞毒活性，其表现出优于母体白藜芦醇化合物的抑制活性。这些化合物与雌激素受体-α 的结合机制通过分子对接研究进行了合理化，表明额外的氢结合相互作用和蛋白质腔中的紧密结合。在用新合成的白藜芦醇类似物处理后，乳腺癌细胞系中 Beclin-1 蛋白表达的诱导表明这些细胞系通过自噬抑制了生长。