threo-p-Methyldiphenylethandiol | 62137-63-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: threo-p-Methyldiphenylethandiol
• 英文别名: threo-1-(p-Tolyl)-2-phenylethandiol；(1R,2R)-1-(4-methylphenyl)-2-phenylethane-1,2-diol
• CAS: 62137-63-7
• 化学式: C₁₅H₁₆O₂
• 分子量: 228.291
• InChiKey: DNBBULKLIIDSLD-HUUCEWRRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-甲基-4-((e)-苯乙烯)-苯 在 potassium osmate(VI) 、 sodium tetrachloropalladate(II) 、 layered double-hydroxides(Mg-Al-Cl) N-甲基吗啉氧化物 、 氢化奎尼定 1,4-(2,3-二氮杂萘)二醚 、 三乙胺 作用下， 以 乙酸乙酯 、 叔丁醇 为溶剂， 生成 threo-p-Methyldiphenylethandiol
  参考文献：
  名称：

  Choudary, Boyapati M.; Chowdari, Naidu S.; Madhi, Sateesh, Angewandte Chemie - International Edition, 2001, vol. 40, # 24, p. 4620 - 4623

  摘要：

  DOI：

文献信息

• Bifunctional Catalysts Stabilized on Nanocrystalline Magnesium Oxide for One-Pot Synthesis of Chiral Diols
  作者：Boyapati?M. Choudary、Karangula Jyothi、Moumita Roy、Mannepalli?L. Kantam、Bojja Sreedhar

  DOI：10.1002/adsc.200404112

  日期：2004.10

  New bifunctional catalysts composed of PdCl42−, OsO42− and OsO42−, WO42− designed and prepared by a counterionic stabilization technique involving the reactions of Na2PdCl4-K2OsO4 and K2OsO4-Na2WO4 with nanocrystalline MgO are well characterized. These bifunctional catalysts, NAP-Mg-PdOs and NAP-Mg-OsW perform tandem Heck asymmetric dihydroxylation and asymmetric dihydroxylation-N-oxidation reactions

  通过涉及Na 2 PdCl 4 -K 2 OsO 4和K 2 OsO 4反应的抗衡离子稳定技术设计和制备了由PdCl 4 2-，OsO 4 2-和OsO 4 2-和WO 4 2-组成的新型双功能催化剂。具有纳米晶体MgO的-Na 2 WO 4得到了很好的表征。这些双功能催化剂NAP-Mg-PdOs和NAP-Mg-OsW进行串联Heck不对称二羟基化和不对称二羟基化-N在一个锅中，在手性配体1,4-双（9-邻-二氢奎宁基）酞嗪[（DHQD）2 PHAL]的存在下分别进行-氧化反应。这是相当可观地注意到，ħ 2 ö 2被用作端子氧化剂提供Ñ甲基吗啉Ñ氧化物（NMO）在原位由氧化Ñ甲基吗啉在不对称dihydroxylation-（NMM）ñ通过催化氧化作用NAP-Mg-OsW。
• Anionic zirconaoxiranes as nucleophilic aldehyde equivalents. Application to intermolecular pinacol cross coupling
  作者：Fredric R. Askham、Kevin M. Carroll

  DOI：10.1021/jo00078a006

  日期：1993.12

  Selective intermolecular pinacol cross coupling is achieved by reaction of anionic zirconaoxiranes with aromatic aldehydes and ketones, thereby providing an efficient route to unsymmetrical vicinal diols.
• An Improved Method for the Preparation of<i>dl</i>-Hydrobenzoin
  作者：André COLLET

  DOI：10.1055/s-1973-22280

  日期：——
• Microbial reduction of a series of substituted benzils. Optical properties and nuclear magnetic resonance spectra of products
  作者：Mitsuru Imuta、Herman Ziffer

  DOI：10.1021/jo00411a012

  日期：1978.8
• The enhanced asymmetric hydrogenation of unsymmetrical benzils to hydrobenzoin catalyzed by organosoluble zirconium phosphonate-immobilized ruthenium catalyst
  作者：Yu Du、Dandan Feng、Jingwei Wan、Xuebing Ma

  DOI：10.1016/j.apcata.2014.03.039

  日期：2014.6

  In this article, a successful design on translating a heterogeneous catalysis of chiral zirconium phosphonate-supported ruthenium catalyst into a homogeneous system was developed by the covalent attachment of chiral (R,R)-1,2-diphenyl-ethylenediamine [(R,R)-DPEN] into the backbone of zirconium phosphonate with the different arm lengths (n = 2, 4, 6) and immobilization of [RuCl2(p-cymene)](2). Their catalytic performances in the homogeneous asymmetric transfer hydrogenation of unsymmetrical benzils with m- and p-substituents were enhanced, and the excellent activities (>97.1% conv.), diastereomeric and enantiomeric purities (syn/anti = 11.0-29.4, 91.8-99.2%ee syn) were achieved. These homogeneous supported Ru catalysts could be quantitatively and readily recovered by addition of ethyl acetate and centrifugation by solid/liquid separation, and be reused for five times without significant loss of their catalytic performances with 97.0% conv., 95.6% syn and syn/anti = 20.7. (C) 2014 Elsevier B.V. All rights reserved.