Tert-butyl 4-tert-butyl-2-methylpiperazine-1-carboxylate | 1236273-01-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: Tert-butyl 4-tert-butyl-2-methylpiperazine-1-carboxylate
• 英文别名: tert-butyl 4-tert-butyl-2-methylpiperazine-1-carboxylate
• CAS: 1236273-01-0
• 化学式: C₁₄H₂₈N₂O₂
• 分子量: 256.389
• InChiKey: FLCQVNJMPSYEPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Tert-butyl 4-tert-butyl-2-methylpiperazine-1-carboxylate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 1-(tert-butyl)3-methyl-piperazine
  参考文献：
  名称：

  Dynamic thermodynamic resolution of lithiated N-Boc-N′-alkylpiperazines

  摘要：

  Deprotonation of N-Boc-N'-alkylpiperazines with sec-BuLi in Et(2)O-TMEDA gave the 2-lithio derivatives which were resolved in the presence of a chiral ligand. The best ligands for the asymmetric substitution were diamino-alkoxides that promoted a dynamic thermodynamic resolution (DTR) of the organolithium at -30 degrees C. Electrophilic quench gave enantiomerically enriched 2-substituted piperazines. Of a selection of piperazines, the N'-t-butyl derivative gave the best results, with the product N-Boc-N'-t-butyl-2-substituted piperazines being formed with enantiomer ratios up to 81:19. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.05.019
• 作为产物：
  描述：

  tert-butyl 4-tert-butylpiperazine-1-carboxylate 、 碘甲烷 在 四甲基乙二胺 、 仲丁基锂 作用下， 以 乙醚 、 正己烷 为溶剂， 反应 5.0h， 以71%的产率得到Tert-butyl 4-tert-butyl-2-methylpiperazine-1-carboxylate
  参考文献：
  名称：

  Dynamic thermodynamic resolution of lithiated N-Boc-N′-alkylpiperazines

  摘要：

  Deprotonation of N-Boc-N'-alkylpiperazines with sec-BuLi in Et(2)O-TMEDA gave the 2-lithio derivatives which were resolved in the presence of a chiral ligand. The best ligands for the asymmetric substitution were diamino-alkoxides that promoted a dynamic thermodynamic resolution (DTR) of the organolithium at -30 degrees C. Electrophilic quench gave enantiomerically enriched 2-substituted piperazines. Of a selection of piperazines, the N'-t-butyl derivative gave the best results, with the product N-Boc-N'-t-butyl-2-substituted piperazines being formed with enantiomer ratios up to 81:19. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.05.019

文献信息

• (4-TERT-BUTYLPIPERAZIN-2-YL)(PIPERAZIN-1-YL)METHANONE-N-CARBOXAMIDE DERIVATIVES
  申请人：Cumming John

  公开号：US20100152197A1

  公开（公告）日：2010-06-17

  The present invention relates to compounds of formula (I) The compounds act via antagonism of the CCR2b receptor and may be used to treat inflammatory disease and/or neuropathic pain.

  本发明涉及公式（I）的化合物。这些化合物通过拮抗CCR2b受体发挥作用，可用于治疗炎症性疾病和/或神经病理性疼痛。
• METHOD OF TREATMENT USING SUBSTITUTED PYRAZOLO[1,5-a] PYRIMIDINE COMPOUNDS
  申请人：Array BioPharma Inc.

  公开号：US20150133429A1

  公开（公告）日：2015-05-14

  Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

  在哺乳动物中，用于合成用于治疗疼痛、癌症、炎症、神经退行性疾病或克鲁茨菌感染的化合物的化合物。
• AMINOQUINAZOLINE AND PYRIDOPYRIMIDINE DERIVATIVES
  申请人：Genentech, Inc.

  公开号：US20170173026A1

  公开（公告）日：2017-06-22

  The invention provides a method of inhibiting angiogenesis in a patient by administering a compound of formula (I): wherein R 1 R 2 and R 3 are as defined herein, compositions including the compounds and methods of using the compounds.
• Method of Treatment Using Substituted Imidazo[1,2b]Pyridazine Compounds
  申请人：Array BioPharma Inc.

  公开号：US20190169193A1

  公开（公告）日：2019-06-06

  Methods for treating a disease or disorder selected from pain, cancer, inflammation, neurodegenerative disease, Typanosoma cruzi infection and osteolytic disease in a mammal, which comprise administering to said mammal a therapeutically effective amount of a compound of Formula I in which R 1 , R 2 , R 3 , R 4 , X, Y and n have the meanings given in the specification.
• US9127013B2
  申请人：——

  公开号：US9127013B2

  公开（公告）日：2015-09-08