1-(2-oxopyrrolidin-1-yl)ethyl piperidine-1-carbamodithioate | 1448145-24-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(2-oxopyrrolidin-1-yl)ethyl piperidine-1-carbamodithioate
• 英文别名: 1-(2-Oxopyrrolidin-1-yl)ethyl piperidine-1-carbodithioate；1-(2-oxopyrrolidin-1-yl)ethyl piperidine-1-carbodithioate
• CAS: 1448145-24-1
• 化学式: C₁₂H₂₀N₂OS₂
• 分子量: 272.436
• InChiKey: WVARODVJYDBOFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  80.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,7-二羟基萘 、 1-(2-oxopyrrolidin-1-yl)ethyl piperidine-1-carbamodithioate 在 aluminum (III) chloride 作用下， 以 氯仿 为溶剂， 以70%的产率得到1-(1-(2,7-dihydroxynaphthalen-1-yl)ethyl)pyrrolidin-2-one
  参考文献：
  名称：

  Synthesis of Dithiocarbamates by Markovnikov Addition Reaction in PEG and Their Application in Amidoalkylation of Naphthols and Indoles

  摘要：

  Synthesis of dithiocarbamates by the one-pot three-component Markovnikov addition reaction of an amine, carbon disulfide and an alkyl vinyl ether or N-vinylpyrrolidone is reported in polyethylene glycol (PEG) under a mild and green procedure with high yields and completely regiospecific. Also, the products were used as efficient starting materials for amidoalkylation of electron-rich arenes such as naphthols and indoles.

  DOI：

  10.5935/0103-5053.20150119
• 作为产物：
  描述：

  哌啶 、 二硫化碳 、 N-乙烯基吡咯烷酮 以 neat (no solvent) 为溶剂， 反应 6.0h， 以90%的产率得到1-(2-oxopyrrolidin-1-yl)ethyl piperidine-1-carbamodithioate
  参考文献：
  名称：

  通过Markovnikov加成反应区域合成二硫代氨基甲酸酯

  摘要：

  摘要 描述了一种通过胺，二硫化碳和N-乙烯基吡咯烷酮的一锅，三组分马尔科夫尼科夫加成反应合成二硫代氨基甲酸酯的简单，有效和区域特异性的方法。 描述了一种通过胺，二硫化碳和N-乙烯基吡咯烷酮的一锅，三组分马尔科夫尼科夫加成反应合成二硫代氨基甲酸酯的简单，有效和区域特异性的方法。

  DOI：

  10.1055/s-0032-1318504

文献信息

• Synthesis of Dithiocarbamates by Markovnikov Addition Reaction in PEG and Their Application in Amidoalkylation of Naphthols and Indoles
  作者：Azim Ziyaei Halimehjani、Arefeh Dadras、Meraj Ramezani、Elham V. Shamiri、Seyyed E. Hooshmand、Mohammad M. Hashemi

  DOI：10.5935/0103-5053.20150119

  日期：——

  Synthesis of dithiocarbamates by the one-pot three-component Markovnikov addition reaction of an amine, carbon disulfide and an alkyl vinyl ether or N-vinylpyrrolidone is reported in polyethylene glycol (PEG) under a mild and green procedure with high yields and completely regiospecific. Also, the products were used as efficient starting materials for amidoalkylation of electron-rich arenes such as naphthols and indoles.
• Regiospecific Synthesis of Dithiocarbamates via a Markovnikov Addition Reaction
  作者：Azim Ziyaei Halimehjani、Hamed Pasha Zanussi、Mohammad Ranjbari

  DOI：10.1055/s-0032-1318504

  日期：——

  Abstract A simple, efficient, and regiospecific method for the synthesis of dithiocarbamates by the one-pot, three-component Markovnikov­ addition reaction of an amine, carbon disulfide, and N-vinylpyrrolidone is described. A simple, efficient, and regiospecific method for the synthesis of dithiocarbamates by the one-pot, three-component Markovnikov­ addition reaction of an amine, carbon disulfide, and

  摘要 描述了一种通过胺，二硫化碳和N-乙烯基吡咯烷酮的一锅，三组分马尔科夫尼科夫加成反应合成二硫代氨基甲酸酯的简单，有效和区域特异性的方法。 描述了一种通过胺，二硫化碳和N-乙烯基吡咯烷酮的一锅，三组分马尔科夫尼科夫加成反应合成二硫代氨基甲酸酯的简单，有效和区域特异性的方法。