4-Hydroxy-1-(β-propyloxy)-2-methyl-naphthalin | 24615-04-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-Hydroxy-1-(β-propyloxy)-2-methyl-naphthalin
• 英文别名: 1-(4-Hydroxy-2-methylnaphthalen-1-yl)oxypropan-2-one
• CAS: 24615-04-1
• 化学式: C₁₄H₁₄O₃
• 分子量: 230.263
• InChiKey: UFAJKPKRXWEMHW-UHFFFAOYSA-N

物化性质

• 沸点：
  423.6±30.0 °C(Predicted)
• 密度：
  1.196±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-Hydroxy-1-(β-propyloxy)-2-methyl-naphthalin 在 air 作用下， 生成 甲萘醌
  参考文献：
  名称：

  Synthesis and Cytotoxicity of 9‐Substituted Benzo[de]chromene‐7,8‐dione and 5‐Benzyl‐9‐substituted Benzo[de]chromene‐7,8‐dione

  摘要：

  New Mansonone analogues of 9-substitued benzo[ de] chromene-7,8-dione 5b-e and 5-benzyl-9-substitued benzo[ de] chromene-7,8-dione 6a-e were prepared through a modified route. The first step involved a bulky base t-butylamine mediated regioselective deacetylation of 2-substituted-1,4-naphth-diyl diacetate, resulting in obtaining of monoacetate 4-acetate 2 in high yield. The mechanism of cyclization, debenzylation, and oxidation for the formation of 5a - e and 6a - e were discussed. The cytotoxicity of the prepared compounds 5 and 6 were comparable with naturally occurring Mansonone F.

  DOI：

  10.1080/00397910600764683
• 作为产物：
  描述：

  1-<β-Oxo-propyloxy>-4--2-methyl-naphthalin 在 草酸 作用下， 生成 4-Hydroxy-1-(β-propyloxy)-2-methyl-naphthalin
  参考文献：
  名称：

  Biflorine发色体系合成1-oxa-phenalen衍生物

  摘要：

  为了通过比较吸收光谱来支持双弗洛林的结构式I，已经合成了1-氧杂苯二烯（II）和1-氧杂苯二烯-7,8-醌的几种衍生物。

  DOI：

  10.1002/hlca.19630460142

文献信息

• Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors
  作者：Wei-Bin Wu、Jie-Bin Ou、Zhi-Hong Huang、Shuo-Bin Chen、Tian-Miao Ou、Jia-Heng Tan、Ding Li、Liu-Lan Shen、Shi-Liang Huang、Lian-Quan Gu、Zhi-Shu Huang

  DOI：10.1016/j.ejmech.2011.04.059

  日期：2011.8

  A series of mansonone F (MF) derivatives were designed and synthesized. These compounds were found to be strong inhibitors for topoisomerases, with much more significant inhibition for topoisomerase II rather than topoisomerase I. The best inhibitor showed 20 times stronger anti-topoisomerase II activity than a positive control Etoposide. The cytotoxic activity of these MF derivatives was evaluated against human cancer cell lines CNE-2 and Glc-82, which showed that these compounds were potent antitumor agents. The structure activity relationships (SARs) study revealed that o-quinone group and pyran ring are important for their cytotoxic activity. (C) 2011 Elsevier Masson SAS. All rights reserved.
• Synthesis and Cytotoxicity of 9‐Substituted Benzo[<i>de</i>]chromene‐7,8‐dione and 5‐Benzyl‐9‐substituted Benzo[<i>de</i>]chromene‐7,8‐dione
  作者：Shi‐Liang Huang、Yi Luo、Zhi‐Shu Huang、Xing‐Yuan Wang、Xian‐Zhang Bu、Pei‐Qing Liu、Lin Ma、Bing‐Fen Xie、Zong‐Chao Liu、Yue‐Ming Li、Albert S. C. Chan

  DOI：10.1080/00397910600764683

  日期：2006.9

  New Mansonone analogues of 9-substitued benzo[ de] chromene-7,8-dione 5b-e and 5-benzyl-9-substitued benzo[ de] chromene-7,8-dione 6a-e were prepared through a modified route. The first step involved a bulky base t-butylamine mediated regioselective deacetylation of 2-substituted-1,4-naphth-diyl diacetate, resulting in obtaining of monoacetate 4-acetate 2 in high yield. The mechanism of cyclization, debenzylation, and oxidation for the formation of 5a - e and 6a - e were discussed. The cytotoxicity of the prepared compounds 5 and 6 were comparable with naturally occurring Mansonone F.
• Synthese eines 1-Oxa-phenalen-Derivates mit dem chromophoren System des Biflorins
  作者：Heather N. Grant、V. Prelog、R. P. A. Sneeden

  DOI：10.1002/hlca.19630460142

  日期：——

  Several derivatives of 1-oxaphenalene (II) and 1-oxaphenalene-7,8-quinone have been synthesized in order to support the constitution I of biflorin by comparison of the absorption spectra.

  为了通过比较吸收光谱来支持双弗洛林的结构式I，已经合成了1-氧杂苯二烯（II）和1-氧杂苯二烯-7,8-醌的几种衍生物。