rac-3-(tritylsulfanyl)-N-(2,3-dihydroxypropyl)propanamide | 850416-23-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: rac-3-(tritylsulfanyl)-N-(2,3-dihydroxypropyl)propanamide
• 英文别名: rac-N-(2,3-Dihydroxypropyl)-3-(trityl-mercapto)propionamide；N-(2,3-dihydroxypropyl)-3-tritylsulfanylpropanamide
• CAS: 850416-23-8
• 化学式: C₂₅H₂₇NO₃S
• 分子量: 421.56
• InChiKey: FORRYFMXWZVJHW-UHFFFAOYSA-N

物化性质

• 熔点：
  223-225 °C
• 沸点：
  663.7±55.0 °C(Predicted)
• 密度：
  1.214±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  30
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  94.9
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  rac-3-(tritylsulfanyl)-N-(2,3-dihydroxypropyl)propanamide 在 三乙基硅烷 、 4-二甲氨基吡啶 、 溶剂黄146 、 三乙胺 、 N,N'-二环己基碳二亚胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 65.0h， 生成 rac-3-[(7-N-(tris(hydroxymethyl)methyl)amino-4-thiapimeloyl)amino]propane-1,2-diyl dioctadecanoate
  参考文献：
  名称：

  Exotic aqueous behavior of synthetic lipids: formation of vesicular nanotubes

  摘要：

  The work reported herein deals with the synthesis and the aggregation behavior studies of synthetic lipids bearing a nonionic polar head made up of a tris(hydroxymethyl) aminomethane (tris) moiety linked with an aminoglycerol interface. The hydrophobic chains with variable lengths were grafted onto the hydroxyl functions of the aminoglycerol residue through ester or carbarnate bonds. Tiny chemical modifications within this family of non-ionic surfactants brought about major variations in their aggregation behavior. They formed vesicles, tubules, and also small stable end-capped tubules - called vesicular nanotubes -, when the polar head bore two heptadecyl chains linked through a carbarnate bond. Various techniques (nanosizer measurements, freeze fracture electron microscopy (FFEM), transmission electron microscopy (TEM), carboxyfluorescein (CF)) encapsulation were used to specify the structure of these assemblies. Notably, the vesicular nanotubes exhibited a small size, a fair polydispersity, great stability in an aqueous solution (up to 1 year) and a good efficiency to entrap and slowly release a probe such as carboxyfluoresceine: all these properties are perfectly suitable for their use as potential drug carriers. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

  DOI：

  10.1016/j.chemphyslip.2005.03.006
• 作为产物：
  描述：

  三苯基氯甲烷 在 2-乙氧基-1-乙氧碳酰基-1,2-二氢喹啉 作用下， 以 二氯甲烷 、 1,2-二氯乙烷 为溶剂， 反应 32.0h， 生成 rac-3-(tritylsulfanyl)-N-(2,3-dihydroxypropyl)propanamide
  参考文献：
  名称：

  Exotic aqueous behavior of synthetic lipids: formation of vesicular nanotubes

  摘要：

  The work reported herein deals with the synthesis and the aggregation behavior studies of synthetic lipids bearing a nonionic polar head made up of a tris(hydroxymethyl) aminomethane (tris) moiety linked with an aminoglycerol interface. The hydrophobic chains with variable lengths were grafted onto the hydroxyl functions of the aminoglycerol residue through ester or carbarnate bonds. Tiny chemical modifications within this family of non-ionic surfactants brought about major variations in their aggregation behavior. They formed vesicles, tubules, and also small stable end-capped tubules - called vesicular nanotubes -, when the polar head bore two heptadecyl chains linked through a carbarnate bond. Various techniques (nanosizer measurements, freeze fracture electron microscopy (FFEM), transmission electron microscopy (TEM), carboxyfluorescein (CF)) encapsulation were used to specify the structure of these assemblies. Notably, the vesicular nanotubes exhibited a small size, a fair polydispersity, great stability in an aqueous solution (up to 1 year) and a good efficiency to entrap and slowly release a probe such as carboxyfluoresceine: all these properties are perfectly suitable for their use as potential drug carriers. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

  DOI：

  10.1016/j.chemphyslip.2005.03.006

文献信息

• Noval Surfactants and Applications Thereof
  申请人：Pucci Bernard

  公开号：US20070275046A1

  公开（公告）日：2007-11-29

  The invention relates to novel surfactant compounds and the use thereof for preparing metastable supramolecular systems or nanoparticles. Said nanoparticles may be used as vectors for active ingredients, in particular therapeutic active ingredients.

  该发明涉及新型表面活性剂化合物及其用于制备亚稳态超分子系统或纳米粒子的用途。所述纳米粒子可用作活性成分的载体，特别是治疗活性成分。
• Exotic aqueous behavior of synthetic lipids: formation of vesicular nanotubes
  作者：Ange Polidori、Nicolas Michel、Anne Sylvie Fabiano、Bernard Pucci

  DOI：10.1016/j.chemphyslip.2005.03.006

  日期：2005.7

  The work reported herein deals with the synthesis and the aggregation behavior studies of synthetic lipids bearing a nonionic polar head made up of a tris(hydroxymethyl) aminomethane (tris) moiety linked with an aminoglycerol interface. The hydrophobic chains with variable lengths were grafted onto the hydroxyl functions of the aminoglycerol residue through ester or carbarnate bonds. Tiny chemical modifications within this family of non-ionic surfactants brought about major variations in their aggregation behavior. They formed vesicles, tubules, and also small stable end-capped tubules - called vesicular nanotubes -, when the polar head bore two heptadecyl chains linked through a carbarnate bond. Various techniques (nanosizer measurements, freeze fracture electron microscopy (FFEM), transmission electron microscopy (TEM), carboxyfluorescein (CF)) encapsulation were used to specify the structure of these assemblies. Notably, the vesicular nanotubes exhibited a small size, a fair polydispersity, great stability in an aqueous solution (up to 1 year) and a good efficiency to entrap and slowly release a probe such as carboxyfluoresceine: all these properties are perfectly suitable for their use as potential drug carriers. (c) 2005 Elsevier Ireland Ltd. All rights reserved.