dichloromethylphosphine | 125750-80-3

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: dichloromethylphosphine
• 英文别名: dichloro-methyl-phosphane；Dichloromethyl-phosphane；dichloromethylphosphane
• CAS: 125750-80-3
• 化学式: CH₃Cl₂P
• 分子量: 116.915
• InChiKey: AWYDVYYDVPFOMZ-UHFFFAOYSA-N

物化性质

• 沸点：
  139.5±30.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  dichloromethylphosphine 在 potassium carbonate 作用下， 生成 methylidynephosphine
  参考文献：
  名称：

  The Gas-Phase Acidity of HCP, CH3CP, HCAs, and CH3CAs: An Unexpected Enhanced Acidity of the Methyl Group

  摘要：

  The gas-phase acidities of methylidynephosphine, HC=P. ethylidynephosphine. CH3C=P. and ethylidynearsine, CH3C=As, have been measured by means of Fourier Transform Ion Cyclotron Resonance (FTICR) mass spectrometry and calculated Lit the CCSD(T)/6-311+G(3df,2p)//QCISD/ 6-311 + G(df.p) level of theory. An analysis of these results shows that, in contrast to the well-known fact that HC=N is a stronger acid than CH3C=N, CH3C=P and CH3C=As are more acidic than HC=P and HC=As, respectively. The most important consequence of this unexpected effect is that while HC=P and HC=As are found to be weaker acids than HC=N. the opposite trend is found for the corresponding methyl derivatives, the acidity of which increases as CH3C=N < CH3C=P < CH3C=As. Also the effects of deprotonation on the structures and the vibrational frequencies of HC=X and CH3C=X (X=N, P, As) compounds are qualitatively similar. but quantitatively very different for nitrogen- as compared with phosphorus- and arsenic-containing compounds. A rationalization of these differences in terms of the bonding differences is presented.

  DOI：

  10.1002/1521-3765(20021104)8:21<4919::aid-chem4919>3.0.co;2-j
• 作为产物：
  描述：

  diethyl (dichloromethyl)phosphonate 在 三(五氟苯基)硼烷 苯硅烷 作用下， 以 甲苯 为溶剂， 生成 dichloromethylphosphine
  参考文献：
  名称：

  B（C 6 F 5）3催化的甲硅烷基化与氢硅烷还原膦酸酯和次膦酸酯的关系

  摘要：

  HSiR 3 / cat-B（C 6 F）3在20°C诱导的磷酯脱烷基化或还原。通过与叔硅烷反应发生了向甲硅烷基酯的特定转化。相反，在与单或二取代的硅烷反应中观察到游离膦。提出了一种机制来使这些结果合理化。

  DOI：

  10.1016/s0040-4039(02)01161-9

文献信息

• Substituted Dihydrophosphinines, Synthesis and Base-Induced Isomerisation
  作者：Annie-Claude Gaumont、Jean-Francois Pilard、Jean-Marc Denis

  DOI：10.1080/10426509608545190

  日期：1996.1

  Abstract The synthesis of α-chloro-tetrahydrophosphinines by inter- or intramolecular [4+2] cycloaddition reactions involving unstabilized phosphaalkenes is presented. Conditions for a selective base-induced isomerisation of substituted dihydrophosphinines are precised. A tautomeric phosphaalkene/vinylphosphine equilibrium was for the first time evidenced.

  摘要 介绍了通过涉及不稳定磷烯烃的分子间或分子内 [4+2] 环加成反应合成 α-氯四氢膦。取代的二氢膦的选择性碱诱导异构化的条件是精确的。首次证明了互变异构磷烯/乙烯基膦平衡。
• Primary α-dichloromethylphosphine; a precursor of unhindered C-chlorophosphaethylene and synthetic equivalent of phospha-acetylene
  作者：J. C. Guillemin、M. Le Guennec、J. M. Denis

  DOI：10.1039/c39890000988

  日期：——

  α-Dichlorophosphine (3), easily obtained by chemoselective phosphonate reduction, is a precursor of the unhindered C-chlorophosphaethylene (4) and a synthetic equivalent of the phospha-acetylene (5).

  α -Dichlorophosphine（3）中，由化学选择性还原膦容易得到，是不受阻碍的前体Ç -chlorophosphaethylene（4）和磷-乙炔（的合成等价物5）。
• Kit for preparing a technetium-99m myocardial imaging agent
  申请人：Mallinckrodt Medical, Inc.

  公开号：US05112594A1

  公开（公告）日：1992-05-12

  A myocardial imaging agent for use in humans comprising a Tc(III) complex ligated in a planar position by a tetradentate ligand having incorporated therein four hard atotms and two furanone rings and in the axial positions by phosphines containing dioxanyl or ether moieties. The agent exhibits improved biodistribution, improved labeling and extremely rapid blood clearance following administration to a human. The agent has high myocardial uptake accompanied with exceptionally rapid hepatobilary clearance and extensive renal clearance to give sufficiently high heart/liver and heart/lung ratio that provide nearly ideal myocardial images in humans. A kit for producing the myocardial imaging agent is provided.

  一种用于人体的心肌成像剂，包括一个Tc（III）配合物，由一个四齿配体以平面位置配位，其中含有四个硬原子和两个呋喃酮环，并且在轴向位置由含有二氧杂环或醚基团的膦配体配位。该剂具有改善的生物分布，改善的标记和极快的血液清除速度，适用于人体。该剂具有高心肌摄取率，伴随着极快的肝胆排泄和广泛的肾排泄，以提供足够高的心脏/肝脏和心脏/肺比率，从而在人类中提供几乎理想的心肌图像。提供了制备心肌成像剂的试剂盒。
• Alkyl-1-alkoxyethylphosphinous acid aluminum salts
  申请人：Ticona GmbH Deutschland KG

  公开号：US06229044B1

  公开（公告）日：2001-05-08

  Aluminum salts of alky-(1-alkoxyethyl)phosphinic acids are prepared by reacting alky-(1-alkoxyethyl)phospihnic acids with aluminum hydroxide in a molar ratio of 3:1. The resulting aluminum phosphinates are used as flame retardants in thermoplastics, particularly in polyesters.

  烷基-(1-烷氧基乙基)膦酸的铝盐是通过将烷基-(1-烷氧基乙基)膦酸与氢氧化铝以3:1的摩尔比反应制备而成。得到的铝膦酸盐用作热塑性材料的阻燃剂，特别是用于聚酯。
• Non-C2-symmetric bisphosphine ligands as catalysts for asymmetric hydrogenation
  申请人：Hoge, II Garrett Stewart

  公开号：US06855849B2

  公开（公告）日：2005-02-15

  Non-C 2 -symmetric bisphospholane ligands and methods for their preparation are described. Use of metal/non-C 2 -symmetric bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.

  本文描述了非C2对称的双膦酰胺配体及其制备方法。还描述了使用金属/非C2对称双膦酰胺配合物催化不对称转化反应，以提供形成化合物的高对映选择性。