3α,17β-diacetoxy-5α-androstane | 1247-66-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3α,17β-diacetoxy-5α-androstane
• 英文别名: 3α,17β-Diacetoxy-5α-androstan；(10S)-3t.17c-Diacetoxy-10r.13c-dimethyl-(5tH.8cH.9tH.14tH)-hexadecahydro-1H-cyclopenta[a]phenanthren；5α-Androstandiyl-(3α.17β)-diacetat；5alpha-Androstane-3alpha,17beta-diol diacetate；[(3R,5S,8R,9S,10S,13S,14S,17S)-17-acetyloxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
• CAS: 1247-66-1
• 化学式: C₂₃H₃₆O₄
• 分子量: 376.536
• InChiKey: BQIBBYLXJDSLIR-QGZPSTLZSA-N

物化性质

• 沸点：
  440.2±18.0 °C(Predicted)
• 密度：
  1.10±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  雄酮 在 吡啶 、 甲醇 、 sodium 作用下， 生成 3α,17β-diacetoxy-5α-androstane
  参考文献：
  名称：

  Open capsular shift for multi directional shoulder instability

  摘要：

  We evaluated the outcome of open antero-inferior capsular shift in 17 patients with multidirectional instability of the shoulder who failed to respond to conservative treatment. Six shoulders presented with secondary impingement syndrome and 11 with involuntary instability. The mean duration of follow-up was 39 months (range 7-89 months). Based on the Rowe and Constant scores and the 12-item questionnaire of Dawson, the results were rated excellent in 14 patients, fair in 2 and poor in 1. All but 2 patients were satisfied with the results, although 6 patients experienced some residual pain, and 4 suffered minor instability. There were no neurovascular complications, infections or symptomatic posterior instability. Open antero-inferior capsular shift yields promising short-term to medium-term results in multidirectional, involuntary instability of the shoulder.

  DOI：

  10.1007/s00402-002-0416-5

文献信息

• Sterols. CVIII. The Preparation of Dihydroandrosterone and Related Compounds from Diosgenin and Tigogenin
  作者：Russell E. Marker

  DOI：10.1021/ja01867a012

  日期：1940.10
• FR797903
  申请人：——

  公开号：——

  公开（公告）日：——
• Cyclic esters and process of preparing same
  申请人：CHEM IND BASEL

  公开号：US02209004A1

  公开（公告）日：1940-07-23
• Esters of polycyclic alcohols and a method of producing the same
  申请人：SCHERING CORP

  公开号：US02192935A1

  公开（公告）日：1940-03-12
• Nature of the Androgens in Female Adrenal Tumor Urine¹
  作者：John K. Wolfe、Louis F. Fieser、H. B. Friedgood

  DOI：10.1021/ja01847a065

  日期：1941.2