9H-fluoren-9-ylmethyl N-[2-(1-tritylimidazol-4-yl)ethyl]carbamate | 224032-28-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 9H-fluoren-9-ylmethyl N-[2-(1-tritylimidazol-4-yl)ethyl]carbamate
• CAS: 224032-28-4
• 化学式: C₃₉H₃₃N₃O₂
• 分子量: 575.71
• InChiKey: HAOZLDKUBDHVPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  44
• 可旋转键数：
  10
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  56.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  三氟乙酸 、 9H-fluoren-9-ylmethyl N-[2-(1-tritylimidazol-4-yl)ethyl]carbamate 以 二氯甲烷 、 水 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  Attachment of histidine, histamine and urocanic acid to resins of the trityl-type

  摘要：

  Histidine, histamine and urocanic acid were attached through the N-im-function on resins of the trityl type. The conditions of the cleavage of these derivatives from the resin were determined. Resin bound histamine was used in the solid phase synthesis of carcinine, (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00270-1
• 作为产物：
  描述：

  组胺 在 sodium carbonate 、 三乙胺 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 氯仿 、 水 为溶剂， 反应 0.5h， 生成 9H-fluoren-9-ylmethyl N-[2-(1-tritylimidazol-4-yl)ethyl]carbamate
  参考文献：
  名称：

  Attachment of histidine, histamine and urocanic acid to resins of the trityl-type

  摘要：

  Histidine, histamine and urocanic acid were attached through the N-im-function on resins of the trityl type. The conditions of the cleavage of these derivatives from the resin were determined. Resin bound histamine was used in the solid phase synthesis of carcinine, (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00270-1

文献信息

• 1,3 AND 1,3,5 SUBSTITUTED IMIDAZOLES AS ANTIHYPERTENSIVES
  申请人：Matsoukas John

  公开号：US20100216854A1

  公开（公告）日：2010-08-26

  The present invention provides novel 1,5 and 1,3,5-substituted imidazole compounds of formulas (I), (IIa), (IIIb) in hydrophilic or lipophilic form, which are useful as angiotensin II AT1 receptor antagonists with sympathetic suppressant properties. In particular, the invention provides pharmaceutical compositions containing the pharmacophoric groups of Losartan and Clonidine as well compounds, processes and intermediates for preparing compounds and their use in methods of treating hypertension and cardiovascular diseases through Renin Angiotensin System (RAS) and Sympathetic System (SS). Alkylated histamine based double action Saltans are lipophilic and can act transdermally.

  本发明提供了新型1,5和1,3,5-取代咪唑化合物的水溶性或脂溶性形式的结构式(I)、(IIa)、(IIIb)，这些化合物可作为具有交感神经抑制作用的血管紧张素II AT1受体拮抗剂。具体而言，本发明提供了含有洛卡特普和可乐定的药理作用基团的药物组合物，以及用于制备化合物的化合物、工艺和中间体，并在通过肾素-血管紧张素系统（RAS）和交感神经系统（SS）治疗高血压和心血管疾病的方法中使用这些化合物。烷基化组织胺双重作用盐类是脂溶性的，并可经皮作用。
• Attachment of histidine, histamine and urocanic acid to resins of the trityl-type
  作者：Sofia Eleftheriou、Dimitrios Gatos、Antonis Panagopoulos、Stephanos Stathopoulos、Kleomenis Barlos

  DOI：10.1016/s0040-4039(99)00270-1

  日期：1999.4

  Histidine, histamine and urocanic acid were attached through the N-im-function on resins of the trityl type. The conditions of the cleavage of these derivatives from the resin were determined. Resin bound histamine was used in the solid phase synthesis of carcinine, (C) 1999 Elsevier Science Ltd. All rights reserved.