α-methyl-β-phenylsuccinic acid | 18734-79-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: α-methyl-β-phenylsuccinic acid
• 英文别名: 2-methyl-3-phenylsuccinic acid；2-methyl-3-phenyl-succinic acid；2-Methyl-3-phenyl-bernsteinsaeure；α-Methyl-α'-Phenyl-bernsteinsaeure；1-Phenyl-propan-dicarbonsaeure-(1.2)；α-Phenyl-propan-α.β-dicarbonsaeure；2-methyl-3-phenylbutanedioic acid
• CAS: 18734-79-7
• 化学式: C₁₁H₁₂O₄
• 分子量: 208.214
• InChiKey: MLAWEKSPGNGPNZ-UHFFFAOYSA-N

物化性质

• 熔点：
  169-172 °C
• 沸点：
  314.9±22.0 °C(Predicted)
• 密度：
  1.284±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  α-methyl-β-phenylsuccinic acid 生成 2-methyl-3-phenyl-succinic acid-anhydride
  参考文献：
  名称：

  Zelinsky; Buchstab, Chemische Berichte, 1891, vol. 24, p. 1879

  摘要：

  DOI：
• 作为产物：
  描述：

  1-丙烯基苯 在 乙基环己烷 作用下， 生成 α-methyl-β-phenylsuccinic acid
  参考文献：
  名称：

  Sodium- and Potassium-Induced Reactions of β-Methylstyrene^1,2

  摘要：

  DOI：

  10.1021/jo01031a074

文献信息

• Nickel-catalyzed reductive electrocarboxylation of disubstituted alkynes
  作者：Elisabet Duñach、Sylvie Dérien、Jacques Périchon

  DOI：10.1016/0022-328x(89)87156-6

  日期：1989.4

  Electrochemically reduced Ni(bipy)3(BF4)2 catalyzes the reaction of carbon dioxide with disubstituted alkynes to yield mono- and di-carboxylated derivatives. The reaction is performed under mild conditions in an undivided cell fitted with a sacrificial magnesium anode.

  电化学还原的Ni（bipy）3（BF 4）2催化二氧化碳与双取代炔烃的反应，生成单羧基和二羧基衍生物。该反应在温和条件下在装有牺牲镁阳极的不分隔电池中进行。
• Efficient electrochemical dicarboxylations of arylacetylenes with carbon dioxide using nickel as the cathode
  作者：Gao-Qing Yuan、Huan-Feng Jiang、Chang Lin

  DOI：10.1016/j.tet.2008.04.053

  日期：2008.6

  excellent total yields (82–94%). Under anhydrous conditions, an unsaturated aryl-maleic anhydride as the main product was obtained, while the presence of H2O would lead to the formation of saturated 2-arylsuccinic acids. The results of cyclic voltammetric experiments show that a nickel cathode itself plays the catalytic role in the reduction reaction of arylacetylenes with CO2.

  在恒定电流和3 MPa的CO 2压力下，在以Ni为阴极，Al为阳极，n -Bu 4 NBr-DMF为辅助电解质的不分隔电池中，芳基乙炔与二氧化碳的电化学二羧基化反应可以顺利实现。和室温下，没有其他催化剂。相应的芳基-马来酸酐和2-芳基琥珀酸的总收率极高（82-94％）。在无水条件下，存在H 2时，得到不饱和芳基-马来酸酐为主要产物。O将导致形成饱和2-芳基琥珀酸。循环伏安实验的结果表明，镍阴极本身在芳基乙炔与CO 2的还原反应中起催化作用。
• Synthesis and dopaminergic activity of<i>trans</i>-4-methyl-3-phenylpyrrolidines
  作者：Kathryn D. Tschappat、A. Michael Crider、Mohamed N. Hassan、Stanley Fahn

  DOI：10.1002/jhet.5570240325

  日期：1987.5

  -propyl)pyrrolidine 13 trans-3-(3-Hydroxyphenyl)-4-methyl-1(n-propy)pyrrolidine 14 were synthesized and evaluated for dopaminergic activity. The stereochemical assignments of 13 and 14 were determined by nmr. Both 13 and 14 were either inactive or weakly active in most dopaminergic tests.

  TRAN -3-（3,4- Dihyroxyphenyl）-4-甲基-1-（正丙基）吡咯烷13 反式-3-（3-羟基苯基）-4-甲基-1-（正丙基）吡咯烷14的合成和评估多巴胺能活性。13和14的立体化学分配由nmr确定。两个13和14是在最多巴胺能测试无活性或弱活性。
• Optical article made of amorphous thermoplastic polyester resin
  申请人：MITSUBISHI RAYON CO., LTD.

  公开号：EP0302516A2

  公开（公告）日：1989-02-08

  An optical article such as optical disk and optical lens, made of an amorphous thermoplastic polyester resin comprised of recurring units, each recurring unit having an aromatic ring in the main chain thereof and an aromatic ring in the side chain thereof. The optical article have a good heat resistance, resistance to absorption of moisture and optical characteristics.

  一种光学产品，如光盘和光学镜片，由无定形热塑性聚酯树脂制成，该树脂由循环单元组成，每个循环单元的主链上有一个芳香环，侧链上有一个芳香环。这种光学产品具有良好的耐热性、抗吸湿性和光学特性。
• 10.1039/d4cc01695e
  作者：Tao, Li、Wang, He、Liu, Xiao-Fei、Ren, Wei-Min、Lu, Xiao-Bing、Zhang, Wen-Zhen

  DOI：10.1039/d4cc01695e

  日期：——

  ring-opening carboxylation of styrene carbonates with CO2 to achieve dicarboxylic acids and/or β-hydroxy acids has been developed via the selective cleavage of the C(sp3)–O bond in cyclic carbonates. The product selectivity is probably determined by the stability and reactivity of the key benzylic radical and carbanion intermediate.

  通过选择性裂解环状碳酸酯中的 C(sp 3 )–O 键，开发了苯乙烯碳酸酯与 CO 2的电还原开环羧化以获得二羧酸和/或β-羟基酸。产物选择性可能由关键的苄基和碳负离子中间体的稳定性和反应性决定。