1,4-bis(2(2-formyl-1-naphthylethynyl)phenylethynyl)benzene | 1301742-82-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1,4-bis(2(2-formyl-1-naphthylethynyl)phenylethynyl)benzene
• 英文别名: 1-[2-[2-[2-[4-[2-[2-[2-(2-Formylnaphthalen-1-yl)ethynyl]phenyl]ethynyl]phenyl]ethynyl]phenyl]ethynyl]naphthalene-2-carbaldehyde；1-[2-[2-[2-[4-[2-[2-[2-(2-formylnaphthalen-1-yl)ethynyl]phenyl]ethynyl]phenyl]ethynyl]phenyl]ethynyl]naphthalene-2-carbaldehyde
• CAS: 1301742-82-4
• 化学式: C₄₈H₂₆O₂
• 分子量: 634.733
• InChiKey: SPHHPRJBIMFCHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.4
• 重原子数：
  50
• 可旋转键数：
  10
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,4-bis(2(2-formyl-1-naphthylethynyl)phenylethynyl)benzene 、 (R)-(-)-2-氨基庚烷 以 氘代氯仿 为溶剂， 反应 1.5h， 生成
  参考文献：
  名称：

  Enantioselective Sensing of Amines Based on [1 + 1]-, [2 + 2]-, and [1 + 2]-Condensation with Fluxional Arylacetylene-Derived Dialdehydes

  摘要：

  Four induced circular dichroism (ICD) probes exhibiting a stereodynamic arylacetylene framework and terminal aldehyde units have been prepared. The CD silent sensors generate a strong chlroptical response to substrate-controlled induction of axial chirality upon selective [1 + 1]-, [2 + 2]-, and [1 + 2]-condensation. The Intense Cotton effects can be exploited for In situ ICD analysis of the absolute configuration and ee of a wide range of amines.

  DOI：

  10.1021/ol200574x
• 作为产物：
  描述：

  1,4-二乙炔基苯 在 copper(l) iodide 、 四(三苯基膦)钯 、 四丁基氟化铵 、 三乙胺 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 51.5h， 生成 1,4-bis(2(2-formyl-1-naphthylethynyl)phenylethynyl)benzene
  参考文献：
  名称：

  Enantioselective Sensing of Amines Based on [1 + 1]-, [2 + 2]-, and [1 + 2]-Condensation with Fluxional Arylacetylene-Derived Dialdehydes

  摘要：

  Four induced circular dichroism (ICD) probes exhibiting a stereodynamic arylacetylene framework and terminal aldehyde units have been prepared. The CD silent sensors generate a strong chlroptical response to substrate-controlled induction of axial chirality upon selective [1 + 1]-, [2 + 2]-, and [1 + 2]-condensation. The Intense Cotton effects can be exploited for In situ ICD analysis of the absolute configuration and ee of a wide range of amines.

  DOI：

  10.1021/ol200574x

文献信息

• Enantioselective Sensing of Amines Based on [1 + 1]-, [2 + 2]-, and [1 + 2]-Condensation with Fluxional Arylacetylene-Derived Dialdehydes
  作者：Daniel P. Iwaniuk、Christian Wolf

  DOI：10.1021/ol200574x

  日期：2011.5.20

  Four induced circular dichroism (ICD) probes exhibiting a stereodynamic arylacetylene framework and terminal aldehyde units have been prepared. The CD silent sensors generate a strong chlroptical response to substrate-controlled induction of axial chirality upon selective [1 + 1]-, [2 + 2]-, and [1 + 2]-condensation. The Intense Cotton effects can be exploited for In situ ICD analysis of the absolute configuration and ee of a wide range of amines.