tert-butyl 3-(but-3-en-1-yl)-3-hydroxypiperidine-1-carboxylate | 1446012-18-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tert-butyl 3-(but-3-en-1-yl)-3-hydroxypiperidine-1-carboxylate
• 英文别名: Tert-butyl 3-but-3-enyl-3-hydroxypiperidine-1-carboxylate；tert-butyl 3-but-3-enyl-3-hydroxypiperidine-1-carboxylate
• CAS: 1446012-18-5
• 化学式: C₁₄H₂₅NO₃
• 分子量: 255.357
• InChiKey: MGQLFZJIGKCVSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl 3-(but-3-en-1-yl)-3-hydroxypiperidine-1-carboxylate 在 草酰氯 、 N,N-二甲基甲酰胺 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 23.0h， 生成 tert-butyl 2-formyl-1-oxa-7-azaspiro[4.5]decane-7-carboxylate
  参考文献：
  名称：

  Synthesis of a Family of Spirocyclic Scaffolds: Building Blocks for the Exploration of Chemical Space

  摘要：

  This report describes the preparation Of a series of 17 novel racemic spirocyclic scaffolds that are intended for the creation of compound libraries by parallel synthesis for biological screening. Each scaffold features two points of orthogonal diversification. The scaffolds are related to each other in four ways: (1) through stepwise changes in the size of the nitrogen-bearing ring; (2) through the oxidation state of the carbon-centered point of diversification; (3) through the relative stereochemical orientation of the two diversification sites in those members that are stereogenic; and (4) through the provision of both saturated and unsaturated versions of the furan ring in the scaffold series derived from 3-piperidone. The scaffolds provide incremental changes in the relative Orientation of the diversity components that would be introduced onto them. The scaffolds feature high sp(3) carbon content which is essential for the three-dimensional exploration Of chemical space. This characteristic is particularly evident in those members of this family that bear two stereocenters, i.e., the two series derived from 3-piperidone and 3-pyrrolidinone. In the series derived from 3-piperidone we were able to "split the difference" between the two diastereomers by preparation of their corresponding unsaturated version.

  DOI：

  10.1021/jo400738b
• 作为产物：
  描述：

  3-Butenylmagnesium bromide 、 N-叔丁氧羰基-3-哌啶酮 在 三氯化铈 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以67%的产率得到tert-butyl 3-(but-3-en-1-yl)-3-hydroxypiperidine-1-carboxylate
  参考文献：
  名称：

  Synthesis of a Family of Spirocyclic Scaffolds: Building Blocks for the Exploration of Chemical Space

  摘要：

  This report describes the preparation Of a series of 17 novel racemic spirocyclic scaffolds that are intended for the creation of compound libraries by parallel synthesis for biological screening. Each scaffold features two points of orthogonal diversification. The scaffolds are related to each other in four ways: (1) through stepwise changes in the size of the nitrogen-bearing ring; (2) through the oxidation state of the carbon-centered point of diversification; (3) through the relative stereochemical orientation of the two diversification sites in those members that are stereogenic; and (4) through the provision of both saturated and unsaturated versions of the furan ring in the scaffold series derived from 3-piperidone. The scaffolds provide incremental changes in the relative Orientation of the diversity components that would be introduced onto them. The scaffolds feature high sp(3) carbon content which is essential for the three-dimensional exploration Of chemical space. This characteristic is particularly evident in those members of this family that bear two stereocenters, i.e., the two series derived from 3-piperidone and 3-pyrrolidinone. In the series derived from 3-piperidone we were able to "split the difference" between the two diastereomers by preparation of their corresponding unsaturated version.

  DOI：

  10.1021/jo400738b

文献信息

• Synthesis of a Family of Spirocyclic Scaffolds: Building Blocks for the Exploration of Chemical Space
  作者：Sarvesh Kumar、Paul D. Thornton、Thomas O. Painter、Prashi Jain、Jared Downard、Justin T. Douglas、Conrad Santini

  DOI：10.1021/jo400738b

  日期：2013.7.5

  This report describes the preparation Of a series of 17 novel racemic spirocyclic scaffolds that are intended for the creation of compound libraries by parallel synthesis for biological screening. Each scaffold features two points of orthogonal diversification. The scaffolds are related to each other in four ways: (1) through stepwise changes in the size of the nitrogen-bearing ring; (2) through the oxidation state of the carbon-centered point of diversification; (3) through the relative stereochemical orientation of the two diversification sites in those members that are stereogenic; and (4) through the provision of both saturated and unsaturated versions of the furan ring in the scaffold series derived from 3-piperidone. The scaffolds provide incremental changes in the relative Orientation of the diversity components that would be introduced onto them. The scaffolds feature high sp(3) carbon content which is essential for the three-dimensional exploration Of chemical space. This characteristic is particularly evident in those members of this family that bear two stereocenters, i.e., the two series derived from 3-piperidone and 3-pyrrolidinone. In the series derived from 3-piperidone we were able to "split the difference" between the two diastereomers by preparation of their corresponding unsaturated version.