2-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one | 906328-94-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one
• 英文别名: 1,3,6,7-tetrahydroxyxanthone-C2-β-D-glucoside；mangiferin；1,3,6,7-tetrahydroxy-2-[(3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one
• CAS: 906328-94-7
• 化学式: C₁₉H₁₈O₁₁
• 分子量: 422.345
• InChiKey: AEDDIBAIWPIIBD-JGPIWLIHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  30
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  197
• 氢给体数：
  8
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  2-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one 在 氢氧化钾 、 sodium hydroxide 作用下， 反应 3.0h， 生成 间苯三酚
  参考文献：
  名称：

  Fujita, Masao; Inoue, Takao, Chemical and pharmaceutical bulletin, 1980, vol. 28, # 8, p. 2476 - 2481

  摘要：

  DOI：

文献信息

• FMO3 inhibitors for treating pain
  申请人：Akron Molecules GmbH

  公开号：EP2674161A1

  公开（公告）日：2013-12-18

  The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies.

  本发明涉及治疗疼痛和相关疾病的新疗法，以及用于上述疗法的药物化合物。
• The mer-[RuCl3(dppb)(H2O)] complex: A versatile tool for synthesis of RuII compounds
  作者：Marilia I.F. Barbosa、Edjane R. dos Santos、Angelica E. Graminha、André L. Bogado、Leticia R. Teixeira、Heloisa Beraldo、Maria Teresa S. Trevisan、Javier Ellena、Eduardo E. Castellano、Bernardo L. Rodrigues、Márcio P. de Araujo、Alzir A. Batista

  DOI：10.1016/j.poly.2010.09.025

  日期：2011.1

  The complex mer-[RuCl3(dppb)(H2O)] [dppb = 1,4-bis(diphenylphosphino)butane] was used as a precursor in the synthesis of the complexes tc-[RuCl2(CO)(2)(dppb)], ct-[RuCl2(CO)(2)(dppb)]. cis-[RuCl2(dppb)(Cl-bipy)], [RuCl(2Ac4mT)(dppb)] (2Ac4mT = N(4)-meta-tolyl-2-acetylpyridine thiosemicarbazone ion) and trans-[RuCl2(dppb)(mang)] (mang = mangiferin or 1,3,6,7-tetrahydroxyxanthone-C2-beta-D-glucoside) complexes. For the synthesis of Run complexes, the Ru-III atom in mer-[RuCl3(dppb)(H2O)] may be reduced by H-2(g), forming the intermediate [Ru2Cl4(dppb)(2)], or by a ligand (such as H2Ac4mT or mangiferin). The X-ray structures of the cis-[RuCl2(dppb)(Cl-bipy)], tc-[RuCl2(CO)(2)(dppb)] and [RuCl(2Ac4mT)(dPpb)] complexes were determined. (C) 2010 Elsevier Ltd. All rights reserved.
• POLYMER COMPOSITION WITH PHYTOCHEMICAL AND DIALYSIS MEMBRANE FORMED FROM THE POLYMER COMPOSITION
  申请人：Chandrasekaran Neelakandan

  公开号：US20110186518A1

  公开（公告）日：2011-08-04

  A biocompatible polymer composition which includes a matrix material and at least one of an isoflavone and a flavone at least partially dispersed in the matrix material is suited to use in a membrane for hemodialysis and other in vivo and in vitro applications.
• POLYMER COMPOSITION AND DIALYSIS MEMBRANE FORMED FROM THE POLYMER COMPOSITION
  申请人：Kyu Thein

  公开号：US20110233138A1

  公开（公告）日：2011-09-29

  A biocompatible polymer composition suited to forming a dialysis membrane includes a matrix material and at least one xanthone. The composition may be formed into a membrane for inserting into a dialyzer filter whereby free radicals in the fluid are removed by the membrane.
• Compounds and Methods for Treating Pain
  申请人：Penninger Josef

  公开号：US20130252924A1

  公开（公告）日：2013-09-26

  The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies.