1,4-Diamino-2,3-dihydroxybutane | 32798-38-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,4-Diamino-2,3-dihydroxybutane
• 英文别名: 1,4-diaminobutane-2,3-diol；rac.-2,3-Dihydroxy-1,4-diamino-butan；2,3-Dihydroxy-1,4-diamino-butan；meso-1,4-Diamino-2,3-dihydroxy-butan；meso-1,4-diamino-2,3-butanediol；1,4-diamino-2,3-butane diol
• CAS: 32798-38-2
• 化学式: C₄H₁₂N₂O₂
• mdl: MFCD19203258
• 分子量: 120.151
• InChiKey: HYXRUUHQXNAFAJ-UHFFFAOYSA-N

物化性质

• 熔点：
  180 °C (sublm)
• 沸点：
  327.2±37.0 °C(Predicted)
• 密度：
  1.230±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  92.5
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,4-Diamino-2,3-dihydroxybutane 、 天然芥菜籽油 以 乙醇 为溶剂， 反应 0.5h， 以69.8%的产率得到N,N'-Bis(allylthiocarbamoyl)-1,4-diaminobutane-2,3-diol
  参考文献：
  名称：

  Synthesis and study of the antiradiation properties of some derivatives of N-allyl-N′-substituted thiocarbamides

  摘要：

  DOI：

  10.1007/bf01146186

文献信息

• Novel double para-phenylenediamines joined by a linker arm substituted with at least one group chosen from hydroxyl, alkoxy, and/or amino groups and method of dyeing keratinous fibers
  申请人：Sabelle Stéphane

  公开号：US20070011827A1

  公开（公告）日：2007-01-18

  Disclosed herein is a novel family of double para-phenylenediamines joined by a linker arm comprising at least one substituent chosen from hydroxyl, alkoxy, and/or amino substituents. Also disclosed herein is a dyeing composition comprising, in a medium suitable for dyeing, at least one para-phenylenediamine joined by a linker arm comprising at least one substituent chosen from hydroxyl, alkoxy, and/or amino substituents. Further disclosed herein is a method for dyeing keratin fibers comprising applying such a dyeing composition to the keratin fibers. A multi-compartment kit comprising at least one dyeing composition of the present disclosure and at least one oxidizing composition is also disclosed herein.

  本文揭示了一类新型的双对苯二胺家族，其由至少选择自羟基、烷氧基和/或氨基取代基的连接臂连接在一起。本文还揭示了一种染料组合物，其中在适合染色的介质中，至少有一种通过连接臂连接的对苯二胺，其连接臂包含至少选择自羟基、烷氧基和/或氨基取代基。此外，本文还揭示了一种染色角蛋白纤维的方法，包括将这种染料组合物应用于角蛋白纤维。本文还揭示了一种多室套装，其中至少包括本公告中的染料组合物和至少一种氧化剂组合物。
• Synthetic<i>N</i>-Acetyl-<scp>d</scp>-glucosamine Based Fully Branched Tetrasaccharide, a Mimetic of the Endogenous Ligand for CD69, Activates CD69⁺Killer Lymphocytes upon Dimerization via a Hydrophilic Flexible Linker
  作者：Anna Kovalová、Miroslav Ledvina、David Šaman、Daniel Zyka、Monika Kubíčková、Lukáš Žídek、Vladimír Sklenář、Petr Pompach、Daniel Kavan、Jan Bílý、Ondřej Vaněk、Zuzana Kubínková、Martina Libigerová、Ljubina Ivanová、Mária Antolíková、Hynek Mrázek、Daniel Rozbeský、Kateřina Hofbauerová、Vladimír Křen、Karel Bezouška

  DOI：10.1021/jm100055b

  日期：2010.5.27

  studies revealed the tetrasaccharide GlcNAcβ1−3(GlcNAcβ1−4)(GlcNAcβ1−6)GlcNAc (compound 52) and its α-benzyl derivative 49 as the best ligand for CD69 with IC50 as high as 10−9 M. This compound thus approaches the affinity of the classical high-affinity neoglycoprotein ligand GlcNAc23BSA. Compound 68, GlcNAc tetrasaccharide 52 dimerized through a hydrophilic flexible linker, turned out to be effective

  上先前已显示对于CD69白细胞受体的内源性配体的高度支化的卵类粘蛋白型undecasaccharide的基础上，基于线性进行较小的寡糖模拟物的系统的调查和支Ñ乙酰基d -hexosamine均低聚物合成制备使用迄今未开发的反应方案。系统的结构活性研究表明，四糖GlcNAcβ1-3（GlcNAcβ1-4）（GlcNAcβ1-6）GlcNAc（化合物52）及其α-苄基衍生物49是CD69的最佳配体，IC 50高达10 -9 M因此，该化合物接近经典的高亲和力新糖蛋白配体GlcNAc的亲和力23 BSA。化合物68，通过亲水性柔性接头二聚的GlcNAc四糖52，证明对激活CD69 +淋巴细胞有效。它也被证明在增强体外自然杀伤，降低体内肿瘤的生长以及激活离体检查的CD69 +肿瘤浸润淋巴细胞方面是有效的。因此，该化合物是具有前景的抗肿瘤潜力的基于碳水化合物的免疫调节剂的候选物。
• [EN] ORTHOESTER COMPOSITIONS FOR AFFINITY PURIFICATION OF OLIGONUCLEOTIDES<br/>[FR] COMPOSITIONS D'ORTHOESTER DESTINÉES À LA PURIFICATION PAR AFFINITÉ D'OLIGONUCLÉOTIDES
  申请人：AGILENT TECHNOLOGIES INC

  公开号：WO2019036029A4

  公开（公告）日：2019-04-11
• Mechanism of Formation and Stabilities of the New Dioxadiazadecalin Systems. Ring−Chain Tautomerism¹
  作者：Alexander Star、Benzion Fuchs

  DOI：10.1021/jo9815554

  日期：1999.2.1

  A linear free energy relationship study is presented for the reactions of threo- and erythro-1,4-diamino- and -2,3-diaminobutanediols (1, 2) with six p-substituted benzaldehydes, the end products of which are the novel cis- and trans-1,5-dioxa-3,7-diazadecalin (DODAD, 7ci, 7tr) and -1,5-diaza-3,7-dioxadecalin (DADOD, 8ci, 8tr) systems. The consecutive double 1,3-oxazane ring closures take place mostly via Schiff bases and are moderately polar ring-chain tautomeric reactions with low positive rho-values (0.69) affected by steric strain, stereoelectronic effects, and intramolecular hydrogen bonds. These are relatively slow processes, which may occur in the solid as well, but are greatly enhanced by acid catalysis.
• MIZRAX L. I.; POLONSKAYA L. YU.; ULANOVSKAYA N. V., ZH. OBSHCH. XIMII, 1979, 49, HO 10, 2393-2394,
  作者：MIZRAX L. I.、 POLONSKAYA L. YU.、 ULANOVSKAYA N. V.

  DOI：——

  日期：——