N'-(4,6-dichloro-1,3,5-triazin-2-yl)ethane-1,2-diamine | 155404-54-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: N'-(4,6-dichloro-1,3,5-triazin-2-yl)ethane-1,2-diamine
• CAS: 155404-54-9
• 化学式: C₅H₇Cl₂N₅
• 分子量: 208.05
• InChiKey: RTEHZVIBZMNANJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-[4-[2-[4-aminophenyl]ethylamino]-6-([3-tert-butoxycarbonylaminophenyl]amino)[1,3,5]triazine-2-ylamino]ethanol 、 N'-(4,6-dichloro-1,3,5-triazin-2-yl)ethane-1,2-diamine 在 碳酸氢钠 作用下， 以 四氢呋喃 、 水 、 丙酮 为溶剂， 生成
  参考文献：
  名称：

  2,4,6-Trisubstituted Triazines as Protein A Mimetics for the Treatment of Autoimmune Diseases

  摘要：

  A first-in-class series of low molecular weight trisubstituted triazines were synthesized and evaluated for their ability to mimic protein A binding to human IgG antibody. The structure-activity relationship (SAR) demonstrates that the 1,3-phenylenediamine component was essential for robust activity. Twenty-two compounds, represented by lead molecule 34, displayed significant activity compared to protein A. These compounds may prove useful for the treatment of autoimmune disease.

  DOI：

  10.1021/jm901403r

文献信息

• SYNTHETIC POLYMERS AND METHODS OF MAKING AND USING THE SAME
  申请人：Battelle Memorial Institute

  公开号：US20160257785A1

  公开（公告）日：2016-09-08

  Disclosed herein are monomer embodiments that can be used to make polymers, such as homopolymers, heteropolymers, and that can be used in particular embodiments to make sequence-defined polymers. Also disclosed herein are methods of making polymers using such monomer embodiments. Methods of using the polymers disclosed herein also are described.

  本文揭示了可用于制造聚合物的单体实施例，例如同聚物、异聚物，并且可以用于特定实施例中制造序列定义的聚合物。本文还揭示了使用此类单体实施例制造聚合物的方法。还描述了使用本文所揭示的聚合物的方法。
• US9365676B2
  申请人：——

  公开号：US9365676B2

  公开（公告）日：2016-06-14
• US9562137B2
  申请人：——

  公开号：US9562137B2

  公开（公告）日：2017-02-07
• [EN] SYNTHETIC POLYMERS AND METHODS OF MAKING AND USING THE SAME<br/>[FR] POLYMÈRES SYNTHÉTIQUES ET PROCÉDÉS DE FABRICATION ET D'UTILISATION DE CEUX-CI
  申请人：BATTELLE MEMORIAL INSTITUTE

  公开号：WO2016036847A9

  公开（公告）日：2017-04-20

  [EN] Disclosed herein are monomer embodiments that can be used to make polymers, such as homopolymers, heteropolymers, and that can be used in particular embodiments to make sequence-defined polymers. Also disclosed herein are methods of making polymers using such monomer embodiments. Methods of using the polymers disclosed herein also are described.
  [FR] L'invention concerne des modes de réalisation de monomères qui peuvent être utilisés pour fabriquer des polymères, tels que des homopolymères, des hétéropolymères, et qui peuvent être utilisés dans des modes de réalisation particuliers pour préparer des polymères à séquence définie. La présente invention concerne également des procédés de fabrication de polymères en utilisant ces modes de réalisation de monomères. L'invention concerne également des procédés d'utilisation des polymères selon l'invention.
• 2,4,6-Trisubstituted Triazines as Protein A Mimetics for the Treatment of Autoimmune Diseases
  作者：Boulos Zacharie、Shaun D. Abbott、Jean-François Bienvenu、Alan D. Cameron、Josée Cloutier、Jean-Simon Duceppe、Abdallah Ezzitouni、Daniel Fortin、Karine Houde、Caroline Lauzon、Nancie Moreau、Valérie Perron、Nicole Wilb、Michel Asselin、André Doucet、Marie-Ève Fafard、Dannyck Gaudreau、Brigitte Grouix、François Sarra-Bournet、Natalie St-Amant、Lyne Gagnon、Christopher L. Penney

  DOI：10.1021/jm901403r

  日期：2010.2.11

  A first-in-class series of low molecular weight trisubstituted triazines were synthesized and evaluated for their ability to mimic protein A binding to human IgG antibody. The structure-activity relationship (SAR) demonstrates that the 1,3-phenylenediamine component was essential for robust activity. Twenty-two compounds, represented by lead molecule 34, displayed significant activity compared to protein A. These compounds may prove useful for the treatment of autoimmune disease.