bis-(POM) methylphosphonate | 1258789-58-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: bis-(POM) methylphosphonate
• 英文别名: [2,2-Dimethylpropanoyloxymethoxy(methyl)phosphoryl]oxymethyl 2,2-dimethylpropanoate
• CAS: 1258789-58-0
• 化学式: C₁₃H₂₅O₇P
• 分子量: 324.311
• InChiKey: ZMOFOELRYYDRDU-UHFFFAOYSA-N

物化性质

• 沸点：
  381.3±27.0 °C(Predicted)
• 密度：
  1.129±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  88.1
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  特戊酸氯甲酯 、 甲基膦酸二甲酯 在 sodium iodide 作用下， 以 乙腈 为溶剂， 反应 72.0h， 生成 bis-(POM) methylphosphonate
  参考文献：
  名称：

  [EN] PHOSPHONATES SYNTHONS FOR THE SYNTHESIS OF PHOSPHONATES DERIVATIVES SHOWING BETTER BIOAVAILABILITY
  [FR] SYNTHONS DE PHOSPHONATES POUR LA SYNTHESE DE DERIVES DE PHOSPHONATES PRESENTANT UNE MEILLEURE BIODISPONIBILITE

  摘要：

  合成磷酸酯前药POM和POC的合成合成子，特别适用于直接交叉烯烃转化。

  公开号：

  WO2010146127A1

文献信息

• [EN] 2'-CHLORO AMINOPYRIMIDINONE AND PYRIMIDINE DIONE NUCLEOSIDES<br/>[FR] NUCLÉOSIDES DE 2'-CHLORO-AMINOPYRIMIDINONE ET PYRIMIDINE DIONE
  申请人：GILEAD SCIENCES INC

  公开号：WO2016028866A1

  公开（公告）日：2016-02-25

  Provided herein are formulations, methods and substituted 2'-chloro aminopyrimidinone and pyrimidine dione compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted 2'-chloro aminopyrimidinone and pyrimidine dione compounds.

  本文提供了用于治疗Pneumovirinae病毒感染（包括呼吸道合胞病毒感染）的配方、方法和替代2'-氯氨基嘧啶酮和嘧啶二酮化合物（I式），以及用于合成替代2'-氯氨基嘧啶酮和嘧啶二酮化合物的方法和中间体。
• aSMase inhibitors
  申请人：Baumann Karl

  公开号：US20100022482A1

  公开（公告）日：2010-01-28

  The present invention relates to compounds of formula wherein the residues have various meanings and their use as pharmaceuticals.

  本发明涉及公式化合物，其中残基具有不同的含义，并将它们用作药物。
• CYANINE DERIVATIVES, FLUORESCENT CONJUGATES CONTAINING SAME AND USE THEREOF
  申请人：Bazin Herve

  公开号：US20100143960A1

  公开（公告）日：2010-06-10

  A subject matter of the invention is cyanine derivatives of formula: in which the dotted lines represent the atoms necessary for the formation of one or two fused aromatic rings, each ring comprising 5 or 6 carbon atoms; R 1 , R 2 , R 3 and R 4 represent, independently of one another: H; substituted or unsubstituted C 1 -C 15 alkyl; C 1 -C 6 alkoxy; (C 2 -C 12 )dialkylamino; C 1 -C 6 alkoxycarbonyl; di(C 2 -C 12 )alkylamido; a substituted or unsubstituted aryl, arylalkyl or aryloxy group; a halogen atom; a nitro; an L1-W, L2-M, L2-A or L2-G group; R 5 and R 6 represent, independently of one another: substituted or unsubstituted C 1 -C 15 alkyl; a substituted or unsubstituted aryl or arylalkyl group; an L1-W, L2-M, L2-A or L2-G group; X is chosen from: O, S or CR 7 R 8 ; Y is chosen from: O, S or CR 9 R 10 ; R 7 , R 8 , R 9 and R 10 independently represent: substituted or unsubstituted C 1 -C 15 alkyl; substituted or unsubstituted aryl, arylalkyl or aryloxy; an L1-W, L2-M, L2-A or L2-G group; R 7 and R 8 and/or R 9 and R 10 can also together form a ring comprising 5 or 6 atoms or a heterocycle comprising 4 to 5 carbon atoms and an oxygen atom; B represents a polymethine bridge comprising 1 to 5 methine groups, said groups being in particular individually unsubstituted or substituted by a substituted or unsubstituted C 1 -C 15 alkyl; a substituted or unsubstituted aryl, arylalkyl or aryloxy group; a nitro group; an L1-W, L2-M, L2-A or L2-G group; L1 and L2 are connecting arms; G is a reactive group; A is a coupling agent; M is a conjugated molecule, W is a phosphate or phosphonate ester (preferably diester), with the proviso that the cyanine derivative comprises at least one L1-W group and at least one L2-A, L2-G or L2-M group.

  本发明的主题是公式的青霉烷衍生物： 其中虚线代表形成一个或两个融合芳香环所需的原子，每个环包含5或6个碳原子；R1、R2、R3和R4独立地表示：H；取代或未取代的C1-C15烷基；C1-C6烷氧基；（C2-C12）二烷基胺；C1-C6烷氧羰基；二（C2-C12）烷基酰胺；取代或未取代的芳基、芳基烷基或芳氧基；卤素原子；硝基；L1-W、L2-M、L2-A或L2-G基团；R5和R6独立地表示：取代或未取代的C1-C15烷基；取代或未取代的芳基或芳基烷基；L1-W、L2-M、L2-A或L2-G基团；X选择自：O、S或CR7R8；Y选择自：O、S或CR9R10；R7、R8、R9和R10独立地表示：取代或未取代的C1-C15烷基；取代或未取代的芳基、芳基烷基或芳氧基；L1-W、L2-M、L2-A或L2-G基团；R7和R8和/或R9和R10还可以共同形成包含5或6个原子的环或包含4到5个碳原子和一个氧原子的杂环；B表示包含1到5个甲烷基的聚甲烷桥，所述的基团特别是单独未取代或取代的C1-C15烷基；取代或未取代的芳基、芳基烷基或芳氧基；硝基；L1-W、L2-M、L2-A或L2-G基团；L1和L2是连接臂；G是反应基团；A是偶联剂；M是共轭分子，W是磷酸酯或膦酸酯（优选为二酯），但青霉烷衍生物至少包括一个L1-W基团和至少一个L2-A、L2-G或L2-M基团。
• Phosphonate Compounds for Treatment of Complement Mediated Disorders
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：US20150239921A1

  公开（公告）日：2015-08-27

  Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R 12 or R 13 on the A group is a phosphonate (R 32 ) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.

  提供了包括式子I或其药学上可接受的盐或组合物的补体因子D抑制剂的化合物、使用方法和制备方法，其中在A基团上的R12或R13是磷酸酯（R32）。本文所述的抑制剂靶向因子D，在替代性补体途径的早期和关键点抑制或调节补体级联反应，并减少因子D调节经典和凝集素补体途径的能力。本文所述的因子D抑制剂能够减少过度激活补体，这与某些自身免疫性、炎症性和神经退行性疾病，以及缺血再灌注损伤和癌症有关。
• 2'-CHLORO AMINOPYRIMIDINONE AND PYRIMIDINE DIONE NUCLEOSIDES FOR USE IN TREATING PNEUMOVIRINAE VIRUS INFECTIONS
  申请人：Gilead Sciences, Inc.

  公开号：EP3738969A1

  公开（公告）日：2020-11-18

  Provided herein are methods involving substituted 2'-chloro aminopyrimidinone and pyrimidine dione compounds for treating Pneumovirinae virus infections, including respiratory syncytial virus infections.

  本文提供了涉及取代的 2'-chloro 氨基嘧啶酮和嘧啶二酮化合物的方法，用于治疗肺炎病毒感染，包括呼吸道合胞病毒感染。