2-Cyano-2-methoximinoacetyl chloride | 111333-65-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Cyano-2-methoximinoacetyl chloride
• 英文别名: (E)-2-cyano-2-methoximino-acetyl chloride；(2E)-2-cyano-2-methoxyiminoacetyl chloride
• CAS: 111333-65-4
• 化学式: C₄H₃ClN₂O₂
• 分子量: 146.533
• InChiKey: RZZQEIUJNKIBRM-XVNBXDOJSA-N

物化性质

• 沸点：
  190.4±23.0 °C(Predicted)
• 密度：
  1.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  62.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Cyano-2-methoximinoacetyl chloride 生成 N-[(E)-2-cyano-2-methoximino-acetyl]-glycine ethyl ester
  参考文献：
  名称：

  LUNKENHEIMER, WINFRIED;BERG, DIETER;BRANDES, WILHELM

  摘要：

  DOI：
• 作为产物：
  描述：

  2-胺基乙酸乙酯 生成 2-Cyano-2-methoximinoacetyl chloride
  参考文献：
  名称：

  LUNKENHEIMER, WINFRIED;BERG, DIETER;BRANDES, WILHELM

  摘要：

  DOI：

文献信息

• (2-cyano-2-oximinoacetyl)-amino acid derivatives
  申请人：Bayer Aktiengesellschaft

  公开号：US04963548A1

  公开（公告）日：1990-10-16

  Novel fungicidally active compounds of the formula ##STR1## in which R represents alkyl, cyanoalkyl or in each case optionally substituted alkenyl, alkinyl, cycloalkyl, cycloalkylalkyl or phenylalkyl, R.sup.1 represents the --OR.sup.2 or --NR.sup.3 R.sup.4 groups, and R.sup.3 and R.sup.4 have special special definitions.

  公式为##STR1##的新型具有杀真菌活性的化合物，其中R代表烷基，氰基烷基或在每种情况下可选地取代的烯基，炔基，环烷基，环烷基烷基或苯基烷基，R.sup.1代表--OR.sup.2或--NR.sup.3 R.sup.4基团，而R.sup.3和R.sup.4具有特殊的定义。
• Fungicidal substituted animals and fungicidal use thereof
  申请人：Bayer Aktiengesellschaft

  公开号：US05210197A1

  公开（公告）日：1993-05-11

  Fungicidal substituted aminals of the formula ##STR1## in which A represents --CO--, --CS-- or --SO.sub.2 --, n represents 0 or 1, R.sup.1 represents optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl, R.sup.2 represents hydrogen or optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl or heterocyclyl, R.sup.3 represents optionally substituted alkyl or may represent in the case where either n is 1 and A represents --SO.sub.2 -- or n is 1 and R.sup.4 represents cycloalkoximino or arylthio, R.sup.4 represents hydrogen, optionally substituted alkyl, alkenyl or alkynyl or bridged or fused radicals, or 1-cyanoalkoximino, --OR.sup.5, --SR.sup.5 or --NR.sup.6 R.sup.7, or R.sup.3 and R.sup.4 together complete a ring.

  化学式为##STR1##的杀真菌取代胺醇，其中A代表--CO--，--CS--或--SO.sub.2--，n代表0或1，R.sup.1代表可选择取代的烷基，烯烃基，炔烃基，环烷基或环烯烃基，R.sup.2代表氢或可选择取代的烷基，烯烃基，炔烃基，环烷基，环烯烃基，芳基或杂环基，R.sup.3代表可选择取代的烷基或者在n为1且A代表--SO.sub.2--或n为1且R.sup.4代表环烷氧肟或芳基硫代时，R.sup.4代表氢，可选择取代的烷基，烯烃基或炔烃基或者桥接或融合基，或1-氰基烷氧肟，--OR.sup.5，--SR.sup.5或--NR.sup.6 R.sup.7，或者R.sup.3和R.sup.4一起构成一个环。
• Fungicidal activity of<i>N</i>-(2-cyano-2-methoximinoacetyl)amino acids and their derivatives
  作者：Paul H. Smith、Keith Chamberlain、Jane M. Sugars、Richard H. Bromilow

  DOI：10.1002/ps.2780440303

  日期：1995.7

  AbstractMore than 20 N‐(2‐cyano‐2‐methoximinoacetyl)amino acids and derivatives were synthesised and tested for antifungal activity against grape downy mildew, caused by Plasmopara viticola (de Bary) Berl. & de Toni, and rape downy mildew, Peronospora parasitica Fr. Two of the compounds containing a free carboxylic acid group, a moiety which has been shown to confer phloem mobility on compounds, showed high activity, especially against P. parasitica, in protectant tests. These results indicate that there is no incompatibility between the acid function and fungicidal activity. A number of the esters showed activity comparable with that of cymoxanil in the protectant tests, and the tert‐butyl esters of the methionine derivative and its sulfone were more than ten times as active as the commercial compound.
• CROWLEY, PATRICK JELF;CHEETHAM, REX;HEANEY, STEPHEN PAUL;BROWN, MARK CARN+
  作者：CROWLEY, PATRICK JELF、CHEETHAM, REX、HEANEY, STEPHEN PAUL、BROWN, MARK CARN+

  DOI：——

  日期：——
• LUNKENHEIMER, WINFRIED;BERG, DIETER;BRANDES, WILHELM
  作者：LUNKENHEIMER, WINFRIED、BERG, DIETER、BRANDES, WILHELM

  DOI：——

  日期：——