N-(2-hydroxy-2-phenylethyl)-2,2,6,6-tetramethylpiperidin-4-ol | 52722-89-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(2-hydroxy-2-phenylethyl)-2,2,6,6-tetramethylpiperidin-4-ol
• 英文别名: 1-(β-hydroxy-phenethyl)-2,2,6,6-tetramethyl-piperidin-4-ol；1-(β-Hydroxy-phenaethyl)-2,2,6,6-tetramethyl-piperidin-4-ol；1-(2'-hydroxy-2'-phenylethyl)-2,2,6,6-tetramethylpiperidin-4-ol；1-[2-Hydroxy-2-phenylethyl]-2,2,6,6-tetramethylpiperidin-4-ol；1-(2-hydroxy-2-phenylethyl)-2,2,6,6-tetramethylpiperidin-4-ol
• CAS: 52722-89-1
• 化学式: C₁₇H₂₇NO₂
• 分子量: 277.407
• InChiKey: URPIVOZCXRINNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  四甲基哌啶酮 在 lithium aluminium tetrahydride 、 乙醚 、 乙醇 、 铂 、 苯 作用下， 生成 N-(2-hydroxy-2-phenylethyl)-2,2,6,6-tetramethylpiperidin-4-ol
  参考文献：
  名称：

  Synthesis of Derivatives of Alkylated and Arylated Piperidones and Piperidinols

  摘要：

  DOI：

  10.1021/jo01360a017

文献信息

• Substituted piperidin-4-ols
  申请人：Ciba-Geigy Corporation

  公开号：US04014887A1

  公开（公告）日：1977-03-29

  Disclosed are stabilized compositions comprising a polymer, especially polyolefines, and a minor proportion of a 1,2,2,6,6-pentasubstituted piperidin-4-ol. The new compositions possess good light stability.

  公开了包含聚合物（尤其是聚烯烃）和少量1,2,2,6,6-五取代吡啶啉-4-醇的稳定化组合物。这些新组合物具有良好的光稳定性。
• General methodology for the chemoselective N-alkylation of (2,2,6,6)-tetramethylpiperidin-4-ol: Contribution of microwave irradiation
  作者：Romain Membrat、Alexandre Vasseur、Laurent Giordano、Alexandre Martinez、Didier Nuel

  DOI：10.1016/j.tetlet.2018.12.020

  日期：2019.1

  A convenient method to access a broad variety of N-alkyl-(2,2,6,6)-tetramethylpiperidin-4-ol compounds is reported. The thermal treatment of a mixture of (2,2,6,6)-tetramethylpiperidin-4-ol and allyl or benzyl bromide derivatives gave the corresponding N-alkylated compounds in good yields while leaving the hydroxyl functional group intact. Whereas 40 h were needed to reach complete conversion, microwave irradiation allowed the reaction time to be reduced (20 min) and improved the yields in most cases. (C) 2018 Elsevier Ltd. All rights reserved.
• US4102870A
  申请人：——

  公开号：US4102870A

  公开（公告）日：1978-07-25
• Synthesis of Derivatives of Alkylated and Arylated Piperidones and Piperidinols
  作者：EVERETT A. MAILEY、ALLAN R. DAY

  DOI：10.1021/jo01360a017

  日期：1957.9