indolizine-1,2,3-triyltris(naphthalen-1-ylmethanone) | 1393956-13-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: indolizine-1,2,3-triyltris(naphthalen-1-ylmethanone)
• 英文别名: [2,3-Bis(naphthalene-1-carbonyl)indolizin-1-yl]-naphthalen-1-ylmethanone；[2,3-bis(naphthalene-1-carbonyl)indolizin-1-yl]-naphthalen-1-ylmethanone
• CAS: 1393956-13-2
• 化学式: C₄₁H₂₅NO₃
• 分子量: 579.654
• InChiKey: NSULWFYJALKTJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.6
• 重原子数：
  45
• 可旋转键数：
  6
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  55.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吡啶 、 1-萘乙酮 在 碘 、 二甲基亚砜 作用下， 反应 36.0h， 以76%的产率得到indolizine-1,2,3-triyltris(naphthalen-1-ylmethanone)
  参考文献：
  名称：

  Convergent domino synthesis of 1,2,3-triaroylindolizines from methyl ketones and pyridines via self-division of labor strategy

  摘要：

  A highly efficient method for the synthesis of 1,2,3-triaroylindolizines has been established from readily available methyl ketones and pyridines in the presence of iodine. This reaction also examplified the self-division of labor strategy in convergent domino synthesis. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.06.091

文献信息

• Convergent domino synthesis of 1,2,3-triaroylindolizines from methyl ketones and pyridines via self-division of labor strategy
  作者：Yan Yang、Meng Gao、Dong-Xue Zhang、Liu-Ming Wu、Wen-Ming Shu、An-Xin Wu

  DOI：10.1016/j.tet.2012.06.091

  日期：2012.9

  A highly efficient method for the synthesis of 1,2,3-triaroylindolizines has been established from readily available methyl ketones and pyridines in the presence of iodine. This reaction also examplified the self-division of labor strategy in convergent domino synthesis. (C) 2012 Elsevier Ltd. All rights reserved.