Aldosteron

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Aldosteron
• 英文别名: (10R,11S,13R,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde
• 化学式: C₂₁H₂₈O₅
• 分子量: 360.45
• InChiKey: PQSUYGKTWSAVDQ-SRPWZAMTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  91.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• SELECTIVE CYP11B1 INHIBITORS FOR THE TREATMENT OF CORTISOL DEPENDENT DISEASES
  申请人：Hartmann Rolf

  公开号：US20140155407A1

  公开（公告）日：2014-06-05

  The present invention relates to compounds which selectively inhibit CYP11B1. Preferably, the compounds of the present invention do not substantially inhibit CYP11B2. Moreover, the compounds of the present invention do not substantially inhibit CYP17 and/or CYP19, either. Amongst other applications of the compounds of the present invention, they can be used for the treatment of Cushing's syndrome or metabolic disease.

  本发明涉及一种选择性抑制CYP11B1的化合物。优选地，本发明的化合物不会显著抑制CYP11B2。此外，本发明的化合物也不会显著抑制CYP17和/或CYP19。在本发明化合物的其他应用中，它们可用于治疗库欣综合征或代谢疾病。
• Novel conjugate compounds and dermatological compositions thereof
  申请人：Tamarkin Dov

  公开号：US20070249571A1

  公开（公告）日：2007-10-25

  The invention relates to novel cosmetic and dermatological compositions, comprising conjugate compounds, including a dicarboxylic acid moiety, which is covalently linked through covalent bonds to a biologically active alcohol, selected from the group of steroidal hormones, steroidal anti-inflammatory agents, vitamin E and vitamin D.
• US9394290B2
  申请人：——

  公开号：US9394290B2

  公开（公告）日：2016-07-19