N,N,N',N'-tetraisopropyldiaminomethane | 6400-26-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N,N',N'-tetraisopropyldiaminomethane
• 英文别名: bis(diisopropylamine)carbene；Bis-diisopropylamino-methan；N,N,N',N'-tetra(propan-2-yl)methanediamine
• CAS: 6400-26-6
• 化学式: C₁₃H₃₀N₂
• 分子量: 214.395
• InChiKey: KFSATLCGQPCVMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N,N',N'-tetraisopropyldiaminomethane 生成 N-isopropyl-N-methylenepropan-2-aminium chloride
  参考文献：
  名称：

  3-(Substituted

  摘要：

  一个化学式为：##SPC1##的化合物。其中R、R.sub.0和R.sub.3是氢或1至3个碳原子的烷基；其中R.sub.1和R.sub.2是1至3个碳原子的烷基，或者组##EQU1##一起是吡咯啉、哌啶、吗啉和N-甲基哌嗪；其中R.sub.7是2-吡啶基或化学式##SPC2##的苯基。其中R.sub.4是氢、氟或氯；其中R.sub.5是氢或氟，但R.sub.5不是氟，当R.sub.4是氯时；其中R.sub.6是氢、氯、氟、溴、三氟甲基或硝基。公式II的新化合物具有镇静和抗焦虑活性，因此对于治疗哺乳动物和鸟类是有用的。

  公开号：

  US03933816A1
• 作为产物：
  描述：

  聚合甲醛 、 二异丙胺 以 水 为溶剂， 生成 N,N,N',N'-tetraisopropyldiaminomethane
  参考文献：
  名称：

  Zinner at al.,G., Chemische Berichte, 1966, vol. 99, p. 1678 - 1688

  摘要：

  DOI：

文献信息

• Interaction of Bis(diisopropylamino)carbene with Aroylimines Activated by Trifluoromethyl Groups
  作者：Dmytro Poliakov、Alexey Rogalyov、Igor Shevchenko

  DOI：10.1002/ejoc.200800571

  日期：2008.12

  Bis(diisopropylamino)carbene deoxygenates the carbonyl group of aroylimines Ar–C(O)–N=C(CF3)2 to form alkenes, which formally result from the coupling of two carbenes, [Ar–C(:)–N=C(CF3)2] and [(iPr2N)2C:]. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

  双（二异丙基氨基）卡宾使芳亚胺 Ar–C(O)–N=C(CF3)2 的羰基脱氧形成烯烃，其形式上由两个卡宾 [Ar–C(:)–N=C (CF3)2] 和 [(iPr2N)2C:]。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
• Process for the production of 1-aminomethyl-6-phenyl-4h-s-triazolo-[4,3-a][
  申请人：The Upjohn Company

  公开号：US03957761A1

  公开（公告）日：1976-05-18

  A multistep process for the production of a compound of the formula V: ##SPC1## wherein R' and R" are alkyl of 1 to 3 carbon atoms, inclusive or together ##EQU1## is pyrrolidino, piperidino, 4-methylpiperazino or morpholino; and wherein the rings A and B are unsubstituted, or substituted by one or more substituents selected from the group consisting of fluoro, chloro, bromo, nitro and trifluoromethyl, which comprises treating an equivalent of a compound of formula 1: ##SPC2## Wherein rings A and B are defined as above, with 2 equivalents of an .alpha.-phthalimido acetyl halide in an inert organic solvent to obtain a 1,3-dioxo-2-isoindolineacetic acid, [[N-(2-benzoylphenyl)-1,3-dioxo-2-isoindolineacetamido]methylene]hydrazide II which when treated with trifluoroacetic acid gives compound III; treating compound III with a dialkylmethyleneammonium chloride in an inert organic solvent to obtain a 2-[3-(dialkylamino)methyl-5-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benz ophenone IV and treating IV with hydrazine in an alkanol to obtain a compound V above. Also claimed are the intermediates II and IV. The 1-aminomethyltriazolobenzodiazepine compounds (V) are used for treatment of anxieties and/or depressions in mammals and birds.

  一种用于生产化合物的多步骤过程，该化合物的分子式为V：其中R'和R"是1至3个碳原子的烷基，包括或一起；是吡咯烷基、哌啶基、4-甲基哌嗪基或吗啉基；环A和环B未取代，或被来自氟、氯、溴、硝基和三氟甲基的一种或多种取代基取代，该过程包括将式1的化合物的当量与2当量的α-邻苯二甲酰亚胺乙酰卤在惰性有机溶剂中处理，以获得1,3-二氧杂-2-异吲哚乙酸，[[N-(2-苯甲酰基苯基)-1,3-二氧杂-2-异吲哚乙酰胺基]亚甲基]肼II，处理III化合物与三氟乙酸，得到化合物III；将化合物III与惰性有机溶剂中的二烷基亚甲基氯化铵处理，得到2-[3-(二烷基氨基)甲基-5-(邻苯二甲酰基甲基)-4H-1,2,4-三唑-4-基]苯并酮IV，并将IV处理与醇中的肼，得到上述化合物V。还声明了中间体II和IV。1-氨甲基三唑苯二氮杂平(V)化合物用于治疗哺乳动物和鸟类的焦虑和/或抑郁症状。
• Synthese und reaktionsverhalten von (dialkylaminomethyl)chlorsilanen und -stannanen
  作者：A. Tzschach、W. Uhlig、K. Kellner

  DOI：10.1016/0022-328x(84)80105-9

  日期：1984.4

  (Dialkylaminomethyl)chlorosilanes have been obtained by the reaction of trichlorosilane with bis(dimethylamino)methane. The corresponding stannanes have been prepared by the addition of methyleneimmonium halides to SnCl2. In the silicon compounds a covalent SiCH2N bond is observed, while the tin compounds have ionic structures. Reactions of the new compounds are described.

  通过三氯硅烷与双（二甲基氨基）甲烷的反应已经获得了（二烷基氨基甲基）氯硅烷。通过将亚甲基卤化铵加到SnCl 2中来制备相应的锡烷。在硅化合物的共价SiCH 2 N键被观察到，而锡化合物具有离子结构。描述了新化合物的反应。
• PREPARATION AND USE OF MAGNESIUM AMIDES
  申请人：Clososki Giuliano Cesar

  公开号：US20100144516A1

  公开（公告）日：2010-06-10

  The present application relates to mixed Mg/Li amides of the general formula R 1 R 2 N—Mg—NR 3 R 4 .zLiY (II) wherein R 1 , R 2 , R 3 , and R 4 are, independently, selected from H, substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or silyl derivatives thereof; and R 1 and R 2 together, or R 3 and R 4 together can be part of a cyclic or polymeric structure; and wherein at least one of R 1 and R 2 and at least one of R 3 and R 4 is other than H; Y is selected from the group consisting of F; Cl; Br; I; CN; SCN; NCO; HaIO n , wherein n=3 or 4 and Hal is selected from Ci, Br and I; NO 3 ; BF 4 ; PF 6 ; H; a carboxylate of the general formula R x CO 2 ; an alcoholate of the general formula OR x ; a thiolate of the general formula SR x ; R x P(O)O 2 ; or SCOR x ; or SCSR x ; O n SR x , wherein n=2 or 3; or NO n , wherein n=2 or 3; and a derivative thereof; wherein R X is a substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or derivatives thereof, or H; m is O or 1; and z>1; as well as a process for the preparation of the mixed Mg/Li amides and the use of these amides, e.g. as bases.

  本申请涉及一般式为R1R2N—Mg—NR3R4.zLiY（II）的混合Mg/Li酰胺，其中R1、R2、R3和R4分别选择自H、含有一个或多个杂原子的取代或未取代的芳基或杂环芳基、线性、支链或环状、取代或未取代的烷基、烯基、炔基或其硅基衍生物；且R1和R2在一起，或R3和R4在一起可以是环状或聚合物结构的一部分；并且至少有一个R1和R2以及至少一个R3和R4不是H；Y选择自F、Cl、Br、I、CN、SCN、NCO、HaIOn，其中n=3或4，Hal选择自Ci、Br和I；NO3；BF4；PF6；H；一般式为RxCO2的羧酸盐；一般式为ORx的醇盐；一般式为SRx的硫醇盐；RxP（O）O2；或SCORx；或SCSRx；OnSRx，其中n=2或3；或NOn，其中n=2或3；及其衍生物；其中RX为取代或未取代的芳基或杂环芳基、线性、支链或环状、取代或未取代的烷基、烯基、炔基或其衍生物，或H；m为O或1；z>1；以及混合Mg/Li酰胺的制备方法和这些酰胺的用途，例如作为碱。
• GROUP 11 MONO-METALLIC PRECURSOR COMPOUNDS AND USE THEREOF IN METAL DEPOSITION
  申请人：BARRY Sean

  公开号：US20120323008A1

  公开（公告）日：2012-12-20

  The present application provides precursor compounds useful for deposition of a group 11 metal on a substrate, for example, a microelectronic device substrate, as well as methods of synthesizing such precursor compounds. The precursor compounds provided are mono-metallic compounds comprising a diaminocarbene (DAC) having the general formula: “DAC-M-X”, where the diaminocarbene is an optionally substituted, saturated N-heterocyclic diaminocarbene (sNHC) or an optionally substituted acyclic diaminocarbene, M is a group 11 metal, such as copper, silver or gold; and X is an anionic ligand. Also provided are methods of synthesizing the precursor compounds, metal deposition methods utilizing such precursor compounds, and to composite materials, such as, e.g., microelectronic device structures, and products formed by use of such precursors and deposition methods.

  本申请提供了前体化合物，用于在衬底上沉积11族金属，例如微电子器件衬底，以及合成这种前体化合物的方法。所提供的前体化合物是单金属化合物，包括具有一般公式“DAC-M-X”的二胺基卡宾（DAC），其中，二胺基卡宾是可选的取代的饱和N-杂环二胺基卡宾（sNHC）或可选的取代的无环二胺基卡宾，M是11族金属，例如铜、银或金；X是一个阴离子配体。还提供了合成前体化合物的方法，利用这种前体化合物的金属沉积方法，以及复合材料，例如微电子器件结构，以及使用这种前体和沉积方法形成的产品。