dicyclohexylnitrone | 100452-71-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: dicyclohexylnitrone
• 英文别名: N-Cyclohexyl-C,C-pentamethylen-nitron；C,C-Pentamethylen-N-cyclohexyl-nitron；N-cyclohexylidenecyclohexanamine-N-oxide；N-cyclohexylcyclohexanimine oxide
• CAS: 100452-71-9
• 化学式: C₁₂H₂₁NO
• 分子量: 195.305
• InChiKey: MUNOGIOVPIYOMF-UHFFFAOYSA-N

物化性质

• 沸点：
  329.4±25.0 °C(Predicted)
• 密度：
  0.98±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  28.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  二环己胺 在 氧气 、 甲基三氧化铼(VII) 作用下， 以 乙腈 为溶剂， 反应 3.5h， 以90%的产率得到dicyclohexylnitrone
  参考文献：
  名称：

  甲基三氧or催化有机氮化合物的好氧氧化

  摘要：

  使用甲基三氧or作为催化剂，已经有效地将各种叔，仲和伯有机氮化合物和分子氧选择性氧化为相应的N-氧化物，硝酮和硝基化合物。

  DOI：

  10.1016/s0040-4039(03)00639-7

文献信息

• Simple Reaction Conditions for the Formation of Ketonitrones from Ketones and Hydroxylamines
  作者：Jennifer Y. Pfeiffer、André M. Beauchemin

  DOI：10.1021/jo901653d

  日期：2009.11.6

  The condensation of ketones and hydroxylamines to form ketonitrones was reinvestigated by using thermal conditions previously found to minimize hydroxylamine decomposition (t-BuOH, 110 °C). This simple approach allows the formation of exocyclic, acyclic, and α,β-unsaturated ketonitrones with benzylic, linear, and branched nitrogen substituents in modest to excellent isolated yields.

  酮和羟胺的缩合形成酮硝基酮通过使用先前发现的使羟胺分解最小化的热条件（t- BuOH，110°C）进行了重新研究。这种简单的方法可以形成环苄基，直链和支链氮取代基的环外，无环和α，β-不饱和酮硝酮，分离出的产率适中。
• Grafting of a rhenium-oxo complex on Schiff base functionalized graphene oxide: an efficient catalyst for the oxidation of amines
  作者：Praveen K. Khatri、Shivani Choudhary、Raghuvir Singh、Suman L. Jain、Om P. Khatri

  DOI：10.1039/c3dt53421a

  日期：——

  A rhenium-oxo complex such as methyltrioxorhenium (MTO) has been homogeneously immobilized on a Schiff base modified graphene oxide (GrO) support via covalent bonding. The loading of MTO on GrO nanosheets was monitored by FTIR, TG-DTA, and elemental analyses. The developed heterogeneous catalyst is found to be efficient for the oxidation of various amines to the corresponding N-oxides using hydrogen

  via-氧配合物（如甲基三氧or）（MTO）已通过共价键合均匀地固定在席夫碱改性的氧化石墨烯（GrO）载体上。通过FTIR，TG-DTA和元素分析监测MTO在GrO纳米片上的负载。发现开发的多相催化剂对于使用过氧化氢作为氧化剂将各种胺氧化为相应的N-氧化物是有效的，且产率高至优异。在反应结束时，催化剂易于通过过滤回收，并重新用于随后的操作。第三次运行后，由于MTO络合物从载体中浸出，催化剂的催化活性略有下降。
• An Unconventional Cobalt-Catalyzed Aerobic Oxidation of Tertiary Nitrogen Compounds to N-Oxides
  作者：Suman L. Jain、Bir Sain

  DOI：10.1002/anie.200390324

  日期：2003.3.17
• Carbon nanofibers decorated with oxo–rhenium complexes: Highly efficient heterogeneous catalyst for oxidation of amines with hydrogen peroxide
  作者：Sanny Verma、Subodh Kumar、Efrat Shawat、Gilbert Daniel Nessim、Suman L. Jain

  DOI：10.1016/j.molcata.2015.03.007

  日期：2015.6

  Pyridine functionalized carbon nanofibers (Py-CNFs) were synthesized, characterized and used for the grafting of oxo-rhenium complex i.e., methyltrioxorhenium (MTO) via acid-base ionic interaction. The grafting of MTO to Py-CNFs was confirmed by FTIR, UV-vis, SEM, TEM and TGA analyses. The determination of rhenium content by ICP-AES further suggested the successful immobilization of MTO to the support. The developed heterogeneous material i.e., MTO@Py-CNFs was found to be an efficient catalyst for the oxidation of various secondary as well as tertiary amines to corresponding nitrones or N-oxides, respectively by using hydrogen peroxide. The developed catalyst was readily recovered by centrifugation and reused for subsequent ten runs without any significant loss in catalytic activity. (C) 2015 Elsevier B.V. All rights reserved.
• Methyltrioxorhenium catalyzed aerobic oxidation of organonitrogen compounds
  作者：Vishal B Sharma、Suman L Jain、Bir Sain

  DOI：10.1016/s0040-4039(03)00639-7

  日期：2003.4

  A variety of tertiary, secondary and primary organonitrogen compounds have been efficiently and selectivity oxidized to their corresponding N-oxides, nitrones, and nitro compounds with molecular oxygen using methyltrioxorhenium as catalyst.

  使用甲基三氧or作为催化剂，已经有效地将各种叔，仲和伯有机氮化合物和分子氧选择性氧化为相应的N-氧化物，硝酮和硝基化合物。