ergosta-7,22-diene-3β-ol | 96391-64-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: ergosta-7,22-diene-3β-ol
• 英文别名: (22E)-ergosta-7,22-dien-3-ol；ergosta-7, 22-dien-3-ol；ergosta-7,22-diene-3-ol；ergosta7,22 dienol；(9R,10S,13R,14R,17R)-17-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 96391-64-9
• 化学式: C₂₈H₄₆O
• 分子量: 398.673
• InChiKey: QOXPZVASXWSKKU-WLUYUHCHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] ANTI-FUNGALS TARGETING THE SYNTHESIS OF FUNGAL SHINGOLIPIDS<br/>[FR] ANTI-FONGIQUES CIBLANT LA SYNTHÈSE DE SHINGOLIPIDES FONGIQUES
  申请人：UNIV NEW YORK STATE RES FOUND

  公开号：WO2016094307A1

  公开（公告）日：2016-06-16

  The present invention provides a compound having the structure: (I).

  本发明提供一种化合物，其结构式为：(I)。
• Extracts and Methods Comprising Cinnamon Species
  申请人：Gow T. Robert

  公开号：US20070292540A1

  公开（公告）日：2007-12-20

  The present invention relates to extracts of cinnamon species plant material prepared by supercritical CO 2 extractions methods.

  本发明涉及采用超临界CO2提取方法制备的肉桂属植物材料的提取物。
• A method and composition for increasing the accumulation of squalene and specific sterols in yeast
  申请人：AMOCO CORPORATION

  公开号：EP0486290A2

  公开（公告）日：1992-05-20

  A method of increasing the accumulation of squalene and specific sterols in yeast comprising increasing the expression level of a structural gene encoding a polypeptide having HMG-CoA reductase activity in a mutant yeast having single or double defects in the expression of sterol biosyntheticenzymes is provided. The expression level of a structural gene is preferably increased by transforming yeast with a recombinant DNA molecule comprising a vector operatively linked to an exogenous DNA segment that encodes a polypeptide having HMG-CoA reductase activity and a promoter that is suitable for driving the expression of the encoded polypeptide in the transformed yeast. The polypeptide having HMG-CoA reductase activity is preferably a truncated, active HMG-CoA reductase enzyme. Recombinant DNA molecules useful for transforming yeast and mutant yeast transformed with such recombinant DNA molecules are also disclosed.

  本发明提供了一种增加酵母中角鲨烯和特定固醇积累的方法，该方法包括在固醇生物合成酶表达存在单缺陷或双缺陷的突变酵母中提高编码具有 HMG-CoA 还原酶活性的多肽的结构基因的表达水平。结构基因的表达水平最好通过用重组 DNA 分子转化酵母来提高，重组 DNA 分子包括与外源 DNA 片段操作性连接的载体，外源 DNA 片段编码具有 HMG-CoA 还原酶活性的多肽和启动子，启动子适于驱动所编码的多肽在转化酵母中的表达。具有 HMG-CoA 还原酶活性的多肽最好是截短的活性 HMG-CoA 还原酶。还公开了用于转化酵母的重组 DNA 分子和用这种重组 DNA 分子转化的突变酵母。
• Anti-fungals targeting the synthesis of fungal shingolipids
  申请人：Del Poeta Maurizio

  公开号：US11390580B2

  公开（公告）日：2022-07-19

  The present invention provides a compound having the structure:

  本发明提供了一种具有以下结构的化合物：
• BIOLOGISCH AKTIVE VERBINDUNGEN AUS GANODERMA PFEIFFERI DMS 13239
  申请人：Ganomycin Gesellschaft für Biomedizinische Forschung mbH

  公开号：EP1158995A1

  公开（公告）日：2001-12-05