(2-(3,4-bis[(trimethylsilyl)-oxy]phenyl)ethoxy)(trimethyl)silane | 68595-80-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (2-(3,4-bis[(trimethylsilyl)-oxy]phenyl)ethoxy)(trimethyl)silane
• 英文别名: 3,4-Dihydroxyphenylaethanol(TMS)3；Ethanol, (2-(3,4-dihydroxyphenyl)-, tris(trimethylsilyl)-；trimethyl-[2-trimethylsilyloxy-4-(2-trimethylsilyloxyethyl)phenoxy]silane
• CAS: 68595-80-2
• 化学式: C₁₇H₃₄O₃Si₃
• 分子量: 370.712
• InChiKey: IAZRADYZGTUREJ-UHFFFAOYSA-N

物化性质

• 沸点：
  344.3±42.0 °C(Predicted)
• 密度：
  0.928±0.06 g/cm3(Predicted)
• 保留指数：
  1756.1

计算性质

• 辛醇/水分配系数(LogP)：
  5.51
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  羟基酪醇 、 N,O-双(三甲基硅烷基)三氟乙酰胺 在 吡啶 作用下， 反应 0.75h， 生成 (2-(3,4-bis[(trimethylsilyl)-oxy]phenyl)ethoxy)(trimethyl)silane
  参考文献：
  名称：

  Lipid-Lowering and Antioxidant Effects of Hydroxytyrosol and Its Triacetylated Derivative Recovered from Olive Tree Leaves in Cholesterol-Fed Rats

  摘要：

  This study was designed to test the lipid-lowering and antioxidative activities of triacetylated hydroxytyrosol compared with its native compound, hydroxytyrosol, purified from olive tree leaves. Wistar rats fed a standard laboratory diet or a cholesterol-rich diet for 16 weeks were used. The serum lipid levels, the thiobarbituric acid-reactive substances (TBARS) level, as an indicator of lipid peroxidation, and the activity of superoxide dismutase (SOD) as well as that of catalase (CAT) were examined. The cholesterol-rich diet induced hypercholesterolemia that was manifested in the elevation of total cholesterol (TC), triglycericles (TG), and. low-density lipoprotein cholesterol (LDL-C). Administration of hydroxytyrosol and triacetylated hydroxytyrosol (3 mg/kg of body weight) decreased the serum levels of TC, TG, and LDL-C significantly and increased the serum level of high-density lipoprotein cholesterol (HDL-C). Furthermore, the content of TBARS in liver, heart, kidney, and aorta decreased significantly when hydroxytyrosol and its triacetylated derivatives were orally administered to rats compared with those fed a cholesterol-rich diet. In addition, triacetylated hydroxytyrosol and hydroxytyrosol increased CAT and SOD activities in the liver. These results suggested that the hypolipidemic effect of triacetylated hydroxytyrosol and hydroxytyrosol might be due to their abilities to lower serum TC, TG, and LDL-C levels as well as to their antioxidant activities preventing the lipid peroxidation process.

  DOI：

  10.1021/jf072589s

文献信息

• Lipid-Lowering and Antioxidant Effects of Hydroxytyrosol and Its Triacetylated Derivative Recovered from Olive Tree Leaves in Cholesterol-Fed Rats
  作者：Hedya Jemai、Ines Fki、Mohamed Bouaziz、Zouhaier Bouallagui、Abdelfattah El Feki、Hiroko Isoda、Sami Sayadi

  DOI：10.1021/jf072589s

  日期：2008.4.1

  This study was designed to test the lipid-lowering and antioxidative activities of triacetylated hydroxytyrosol compared with its native compound, hydroxytyrosol, purified from olive tree leaves. Wistar rats fed a standard laboratory diet or a cholesterol-rich diet for 16 weeks were used. The serum lipid levels, the thiobarbituric acid-reactive substances (TBARS) level, as an indicator of lipid peroxidation, and the activity of superoxide dismutase (SOD) as well as that of catalase (CAT) were examined. The cholesterol-rich diet induced hypercholesterolemia that was manifested in the elevation of total cholesterol (TC), triglycericles (TG), and. low-density lipoprotein cholesterol (LDL-C). Administration of hydroxytyrosol and triacetylated hydroxytyrosol (3 mg/kg of body weight) decreased the serum levels of TC, TG, and LDL-C significantly and increased the serum level of high-density lipoprotein cholesterol (HDL-C). Furthermore, the content of TBARS in liver, heart, kidney, and aorta decreased significantly when hydroxytyrosol and its triacetylated derivatives were orally administered to rats compared with those fed a cholesterol-rich diet. In addition, triacetylated hydroxytyrosol and hydroxytyrosol increased CAT and SOD activities in the liver. These results suggested that the hypolipidemic effect of triacetylated hydroxytyrosol and hydroxytyrosol might be due to their abilities to lower serum TC, TG, and LDL-C levels as well as to their antioxidant activities preventing the lipid peroxidation process.