N-(6-cyanopyridin-3-yl)acrylamide | 1170774-18-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(6-cyanopyridin-3-yl)acrylamide
• 英文别名: N-(6-cyanopyridin-3-yl)prop-2-enamide
• CAS: 1170774-18-1
• 化学式: C₉H₇N₃O
• 分子量: 173.174
• InChiKey: PTPGCBZFZYHOGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  65.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-chloro-N-(6-cyanopyridin-3-yl)propanamide 生成 N-(6-cyanopyridin-3-yl)acrylamide
  参考文献：
  名称：

  Deore, Vijaykumar; Bhonde, Mandar R.; Vishwakarma, Ram A., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009, vol. 48, # 12, p. 1761 - 1765

  摘要：

  DOI：

文献信息

• Synthesis and therapeutic evaluation of pyridyl based novel mTOR inhibitors
  作者：Vijaykumar Deore、Nilambari Yewalkar、Dimple Bhatia、Nikesh Desai、Ravindra D. Gupte、Shruta S. Dadarkar、Mahesh G. Jadhav、Aditi A. Tannu、Pooja Bhatt、Kumar V.S. Nemmani、Ram A. Vishwakarma、Somesh Sharma、Abhijit Roychowdhury、Nilesh M. Dagia、Mandar R. Bhonde、Sanjay Kumar

  DOI：10.1016/j.bmcl.2009.04.055

  日期：2009.6

  A series of novel cyanopyridyl based molecules (1-14) were designed, synthesized and probed for inhibition of mammalian target of rapamycin (mTOR) activity. Compound 14 was found to be a potent inhibitor of mTOR activity as assessed by enzyme-linked immunoassays and Western blot analysis. Most importantly, systemic application (intraperitoneal; ip) of compound 14 significantly suppressed macroscopic and histological abnormalities associated with chemically-induced murine colitis. (C) 2009 Elsevier Ltd. All rights reserved.
• Deore, Vijaykumar; Bhonde, Mandar R.; Vishwakarma, Ram A., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009, vol. 48, # 12, p. 1761 - 1765
  作者：Deore, Vijaykumar、Bhonde, Mandar R.、Vishwakarma, Ram A.、Dagia, Nilesh M.、Kumar, Sanjay、Roychowdhury, Abhijit

  DOI：——

  日期：——