(E)-8-((2-chloroethylamino)methylene)-4-methyl-2,7-dioxo-7,8-dihydro-2H-benzo[h]chromene-10-carbaldehyde | 1345732-92-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: (E)-8-((2-chloroethylamino)methylene)-4-methyl-2,7-dioxo-7,8-dihydro-2H-benzo[h]chromene-10-carbaldehyde
• 英文别名: (8E)-8-[(2-chloroethylamino)methylidene]-4-methyl-2,7-dioxobenzo[h]chromene-10-carbaldehyde
• CAS: 1345732-92-4
• 化学式: C₁₈H₁₄ClNO₄
• 分子量: 343.766
• InChiKey: MRAAYMIBSSTZFX-DHZHZOJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.59
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  76.38
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  1,5-二羟基萘 在 对甲苯磺酸 、 三氟乙酸 作用下， 以 乙醇 为溶剂， 反应 9.17h， 生成 (E)-8-((2-chloroethylamino)methylene)-4-methyl-2,7-dioxo-7,8-dihydro-2H-benzo[h]chromene-10-carbaldehyde
  参考文献：
  名称：

  Discovery and synthesis of novel substituted benzocoumarins as orally active lipid modulating agents

  摘要：

  The synthesis of a series of benzocoumarin keto-enamine schiff bases is reported. The novel compounds were evaluated for their antihyperlipidemic activity in the hyperlipidemic hamster model. The compound 11 at a dose of 10 mg/kg body weight significantly lowered the plasma triglyceride levels (TG) by 70%, total cholesterol (TC) by 47%, accompanied by an increase in HDL-C/TC ratio by 80% in hyperlipidemic hamsters to a greater degree than the reference drugs atorvastatin and lovastatin. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.09.053

文献信息

• Discovery and synthesis of novel substituted benzocoumarins as orally active lipid modulating agents
  作者：Koneni V. Sashidhara、Manoj Kumar、Ram K. Modukuri、Anuj Srivastava、Anju Puri

  DOI：10.1016/j.bmcl.2011.09.053

  日期：2011.11

  The synthesis of a series of benzocoumarin keto-enamine schiff bases is reported. The novel compounds were evaluated for their antihyperlipidemic activity in the hyperlipidemic hamster model. The compound 11 at a dose of 10 mg/kg body weight significantly lowered the plasma triglyceride levels (TG) by 70%, total cholesterol (TC) by 47%, accompanied by an increase in HDL-C/TC ratio by 80% in hyperlipidemic hamsters to a greater degree than the reference drugs atorvastatin and lovastatin. (C) 2011 Elsevier Ltd. All rights reserved.